Novel 9-bp indel in visfatin gene and its associations with chicken growth

Han, Ran; Li, Z J; Li, M J; Li, J Q; Lan, Xianyong; Sun, Guirong; Kang, Xiangtao; Chen, H

doi:10.1080/00071668.2010.537310

Cited by 59 publications

(36 citation statements)

References 21 publications

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“…In this study, we used an F 2 resource family, whose details have been described in a previous study (Han et al, 2011). Seventy F 1 animals (7 males, 63 females) were produced from Gushi chickens (24 hens and 2 roosters) and Anak broilers (12 hens and 4 roosters).…”

Section: Resource Populationsmentioning

confidence: 99%

Adjacent SNPs in the transcriptional regulatory region of the FADS2 gene associated with fatty acid and growth traits in chickens

Zhu¹,

Tian²,

Zhang³

et al. 2014

Genet. Mol. Res.

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ABSTRACT. Delta-6 fatty acid desaturases are rate-limiting desaturases involved in metabolic processes of fatty acids, and they are encoded by the FADS2 gene. In the current study, an F 2 resource population of Gushi chickens crossed with Anak broilers was used to investigate the genetic effects of the chicken FADS2. Two adjacent single nucleotide polymorphisms (SNPs) (g.4290C>G and g.4291C>A) were identified in the transcriptional regulatory region of the FADS2 gene by means of polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and created restriction site-PCR-RFLP. Associations between the two SNPs with chicken fatty acid contents and growth traits were determined using linkage disequilibrium, haplotype construction, and association analysis. The two SNPs and their haplotype combinations were significantly associated with linoleic

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Section: Resource Populationsmentioning

confidence: 99%

Adjacent SNPs in the transcriptional regulatory region of the FADS2 gene associated with fatty acid and growth traits in chickens

Zhu¹,

Tian²,

Zhang³

et al. 2014

Genet. Mol. Res.

Self Cite

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“…Carcass traits including carcass weight (CW), semi-evisceration weight (SEW), evisceration weight (EW), abdominal fat weight (AFW), leg weight (LW), leg muscle weight (LMW), breast muscle weight (BMW) were weighted. And meat quality traits including skin fat thickness (SFT), breast muscle water loss rate (BWLR), breast muscle pH (BPH), breast muscle shear force (BSF), leg muscle water loss rate (LWLR), leg muscle pH (LPH), leg muscle shear force (LSF) and fat content of dry sample (FCDS) and fat content of fresh sample (FCFS) were measured [20].…”

Section: Chicken Samples and Traits Measurementmentioning

confidence: 99%

Association study of a common genetic variant in pre-miR-1596 with chicken performance traits

et al. 2014

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Increasing reports have verified that miRNAs had an important effect on the growth and development in farm animals. To evaluate the possible effect of miR-1596 polymorphisms on chicken economic traits, directly sequencing and polymerase chain reaction-restriction fragment length polymorphism, association analysis as well as online software were used. The results showed that a C > T polymorphism existed in the miR-1596 gene of the Gushi × Anka F2 resource population. The association analysis showed that it was significantly relevant with the potential of hydrogen of leg muscle, fat content of dry sample and fat content of fresh sample, shank length at 0 day and 4 weeks of age; leg weight, leg muscle weight, and breast muscle weight (P < 0.05); and highly significant association with shank girth at 8 weeks of age and abdominal fat weight (P < 0.01). We predicted the secondary structure of Gallus gallus-miR-1596 (gga-miR-1596) and the free energy by using M-fold, which were not altered. MiR-1596 is conserved between chicken and turkey. Our data implied that miR-1596 might participate in regulating the muscle development and adipogenesis.

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“…A total of 860 genomic DNA samples were extracted from serum blood samples of F 2 individuals using the phenol-chloroform method [42]. Growth traits including body weight and body size were recorded at different stages, and traits including carcass, meat quality and blood biochemistry parameters were carefully measured after slaughter [43,44].…”

Section: Snp Detection and Association Analysismentioning

confidence: 99%

Transcriptome Profile Analysis Reveals an Estrogen Induced LncRNA Associated with Lipid Metabolism and Carcass Traits in Chickens (Gallus Gallus)

Yang

et al. 2018

Cell Physiol Biochem

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Background/Aims: Accumulating evidences have demonstrated that long noncoding RNAs (lncRNA) play important roles in hepatic lipid metabolism in mammals. However, no systematic screening of the potential lncRNAs in the livers of laying hens has been performed, and few studies have been reported concerning the effects of the lncRNAs on lipid metabolism in the livers of chickens during egg-laying period. The purpose of this study was to compare the difference in lncRNA expression in the livers of pre-laying and peak-laying hens at the age of 20 and 30 weeks old by transcriptome sequencing and to investigate the interaction networks among lncRNAs, mRNAs and miRNAs. Moreover, the regulatory mechanism and biological function of lncLTR, a significantly differentially expressed lncRNA in the liver between pre- and peak-laying hens, was explored in vitro and in vivo. Methods: Bioinformatics analyses were conducted to identify the differentially expressed (DE) lncRNAs between the two groups of hens. The target genes of the DE lncRNA were predicated for further functional enrichment. An integrated analysis was performed among the DE lncRNA datasets, DE mRNAs and DE miRNA datasets obtained from the same samples to predict the interaction relationship. In addition, in vivo and in vitro trials were carried out to determine the expression regulation of lncLTR, and polymorphism association analysis was conducted to detect the biological role of ncLTR. Results: A total of 124 DE lncRNAs with a P-value ≤ 0.05 were identified. Among them, 44 lncRNAs including 30 known and 14 novel lncRNAs were significant differentially expressed (SDE) with FDR ≤ 0.05. Thirty-two lncRNAs were upregulated and 12 were downregulated in peak-laying group compared with pre-laying group. The functional enrichment results revealed that target genes of some lncRNAs are involved in the lipid metabolism process. Integrated analysis suggested that some of the genes involved in lipid metabolism might be regulated by both the lncRNA and the miRNA. In addition, an upregulated lncRNA, designated lncLTR, was demonstrated to be induced by estrogen via ERβ signaling. The c242. G>A SNP in lncLTR was significantly associated with chicken carcass weight, evisceration weight, semi-evisceration weight, head weight, double-wing weight, claw weight traits, and blood biochemical index, especially for the blood triglyceride content. Conclusion: A series of lncRNAs associated with lipid metabolism in the livers of chickens were identified by transcriptome sequencing and functional analysis, providing a valuable data resource for further studies on chicken hepatic metabolism activities. LncLTR was regulated by estrogen via ERβ signaling and associated with chicken carcass trait and blood triglyceride content.

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Novel 9-bp indel in visfatin gene and its associations with chicken growth

Cited by 59 publications

References 21 publications

Adjacent SNPs in the transcriptional regulatory region of the FADS2 gene associated with fatty acid and growth traits in chickens

Adjacent SNPs in the transcriptional regulatory region of the FADS2 gene associated with fatty acid and growth traits in chickens

Association study of a common genetic variant in pre-miR-1596 with chicken performance traits

Transcriptome Profile Analysis Reveals an Estrogen Induced LncRNA Associated with Lipid Metabolism and Carcass Traits in Chickens (Gallus Gallus)

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