Novel 5-HTTLPR Allele Associates with Higher Serotonin Transporter Binding in Putamen: A [11C] DASB Positron Emission Tomography Study

Cerebral serotonin transporter binding is inversely related to body mass index

“…Estimate the long 5-HTTLPR allele who also have the A variation at rs25531 (Praschak-Rieder et al, 2007;Reimold et al, 2007;Kalbitzer et al, 2009) then there is some support for genetic basis for our finding. Adaptive changes of the serotonergic neurotransmission to environmental factors during early development could also take place.…”

A Nonlinear Relationship between Cerebral Serotonin Transporter and 5-HT2AReceptor Binding: AnIn VivoMolecular Imaging Study in Humans

“…By its selective reuptake of 5-HT, SERT is the key regulator of the synaptic levels of this transmitter. For example, the short allele of the SCL6A4 serotonin transporter-linked polymorphic region (5-HTTLPR) polymorphism confers decreased SERT expression (Lesch et al, 1996;Little et al, 1998;Heinz et al, 2000) and binding, especially when taking the triallelic variation in the 5-HTTLPR into account (Praschak-Rieder et al, 2007;Reimold et al, 2007), although conflicting data exist (Greenberg et al, 1999;Mann et al, 2000;Preuss et al, 2000;van Dyck et al, 2004;Parsey et al, 2006). Currently, there are no published studies available to address whether the SCL6A4 5-HTTLPR polymorphism or other functional SERT polymorphisms have any impact on cerebral 5-HT 2A receptor binding in humans.…”

Suicide ideators and attempters with schizophrenia – The role of 5-HTTLPR, rs25531, and 5-HTT VNTR Intron 2 variants

“…The 5-HTT promoter harbors a functional 43 bp insertion/deletion polymorphism (5-HTTLPR), which yields a short and a long allele. The S allele is associated with a nearly 50% reduction of basal 5-HTT activity in vitro (Heils et al, 1996) and reduced in vivo 5-HTT binding in Caucasians (Praschak-Rieder et al, 2007). Other polymorphisms have been found in the proximity of the Ins/Del locus such as rs 25531, rs 25532, rs 2020933.…”