Novel 3D-Printed Dressings of Chitosan–Vanillin-Modified Chitosan Blends Loaded with Fluticasone Propionate for Treatment of Atopic Dermatitis

Abstract

In the present study, the blends of CS and Vanillin–CS derivative (VACS) were utilized for the preparation of printable inks for their application in three-dimensional (3D) printing procedures. Despite the synergic interaction between the blends, the addition of ι-carrageenan (iCR) as a thickening agent was mandatory. Their viscosity analysis was conducted for the evaluation of the optimum CS/VACS ratio. The shear thinning behavior along with the effect of the temperature on viscosity values were evident. Further characterization of the 3D-printed structures was conducted. The effect of the CS/VACS ratio was established through swelling and contact angle measurements. An increasing amount of VACS resulted in lower swelling ability along with higher hydrophobicity. Fluticasone propionate (FLU), a crystalline synthetic corticosteroid, was loaded into the CS/VACS samples. The drug was loaded in its amorphous state, and consequently, its in vitro release was significantly enhanced. An initial burst release, followed by a sustained release profile, was observed.

Exploring the Blends’ Miscibility of a Novel Chitosan Derivative with Enhanced Antioxidant Properties; Prospects for 3D Printing Biomedical Applications

“…The positive values of the µ and α factors prove the miscibility of the blends in all the studied ratios. Furthermore, the strong interactions between the CS and CS-MVP polymers in the ratios of 60:40, 50:50, and 40:60 are also evident in Figure 8e, CS blends have already been examined by our group for drug delivery of chloramphenicol [27] and fluticasone propionate, and their application in 3D printing has already been established [11,43]. Within this scope, concentrated inks of high viscosity were formulated with the CS/CS-MVP blends, and their potential application in pneumatic 3D extrusion was examined.…”

“…CS blends have already been examined by our group for drug delivery of chloramphenicol [27] and fluticasone propionate, and their application in 3D printing has already been established [11,43]. Within this scope, concentrated inks of high viscosity were formulated with the CS/CS-MVP blends, and their potential application in pneumatic 3D extrusion was examined.…”

Functionalization of Arabinoxylan in Chitosan Based Blends by Periodate Oxidation for Drug Release Study

“…It is noteworthy that the OAX/CS blend with the highest CS concentration (OAX/CS 1 : 2) demonstrated an effective drug release profile attributed to its minimal swelling ratio, as result of intermolecular hydrogen bonding between the −NH 2 − group of CS and the carbonyl group of OAX. This resulted in a gradual and sustained release of the drug, which highlights its potential as a favorable candidate for sustained drug delivery applications [58,59] .…”