Novel 3D printed device with integrated macroscale magnetic field triggerable anti-cancer drug delivery system

Shi, Kejing; Aviles-Espinosa, Rodrigo; Rendon-Morales, Elizabeth; Woodbine, Lisa; Maniruzzaman, Mohammed; Nokhodchi, Ali

doi:10.1016/j.colsurfb.2020.111068

Cited by 16 publications

(8 citation statements)

References 30 publications

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“…The shape, dimensions and internal structure of the object can be highly customised due to layer-by-layer fabrication allowing for fabrication of unique objects and devices [42]. In one such example, extrusionbased 3D printing was used to fabricate the drug reservoir and capsule of a magnetically triggered drug release device [43]. The capsule contained a magnetic PDMS sponge, which was loaded with drugs, and an aperture at one end for drug release.…”

Section: Extrusion-based 3dpmentioning

confidence: 99%

3D Printing in Triggered Drug Delivery Devices: A Review

Cheung

Lee

et al. 2022

Biomedical Materials & Devices

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Triggered drug delivery devices use external stimulus to trigger the release of the drugs from the device. By controlling the exposure of the stimuli, it would allow for the control over the timing, duration and amount of drug being released from the device, improving drug efficacy. 3D printing uses on-demand deposition and crosslinking of materials to fabricate a product, increasing the customisability of the design and internal structure. By using 3D printing to fabricate triggered drug delivery devices, certain advantages such as complex geometries, gradient compositions, multi-material structures and embedded components can be conferred to the printed devices. In this review paper, triggered drug delivery devices which are fabricated using 3D printing techniques such as vat photopolymerisation and material extrusion are discussed. The advancement in certain areas of 3D printing, such as in multi-material 3D printing and hybrid additive manufacturing, which presents tremendous opportunities for fabricating future triggered drug delivery devices will also be reviewed.

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Section: Extrusion-based 3dpmentioning

confidence: 99%

3D Printing in Triggered Drug Delivery Devices: A Review

Cheung

Lee

et al. 2022

Biomedical Materials & Devices

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“…A magnetic sponge cylinder with a 3D printed reservoir exhibited on-demand, localized delivery of 5-fluorouracil as triggered by varying strengths of magnetic fields applied using an external device, enabling long-term, efficient carcinogenic cell inhibition. On-demand delivery is ensured as higher drug dose is released upon application of higher magnetic field and vice versa (87). Utilization of 3D printing for the production of PM is owing to its characteristics of precisely manufacturing intricate shapes and allowing easy modifications.…”

Section: Three-dimensional Printed Personalized Drug Delivery For Cancermentioning

confidence: 99%

3D Printed Personalized Medicine for Cancer: Applications for Betterment of Diagnosis, Prognosis and Treatment

2021

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Cancer treatment is challenging due to the tumour heterogeneity that makes personalized medicine a suitable technique for providing better cancer treatment. Personalized medicine analyses patient-related factors like genetic make-up and lifestyle and designs treatments that offer the benefits of reduced side effects and efficient drug delivery. Personalized medicine aims to provide a holistic way for prevention, diagnosis and treatment. The customization desired in personalized medicine is produced accurately by 3D printing which is an established technique known for its precision. Different 3D printing techniques exhibit their capability in producing cancer-specific medications for breast, liver, thyroid and kidney tumours. Three-dimensional printing displays major influence on cancer modelling and studies using cancer models in treatment and diagnosis. Three-dimensional printed personalized tumour models like physical 3D models, bioprinted models and tumour-onchip models demonstrate better in vitro and in vivo correlation in drug screening, cancer metastasis and prognosis studies. Three-dimensional printing helps in cancer modelling; moreover, it has also changed the facet of cancer treatment. Improved treatment via custommade 3D printed devices, implants and dosage forms ensures the delivery of anticancer agents efficiently. This review covers recent applications of 3D printed personalized medicine in various cancer types and comments on the possible future directions like application of 4D printing and regularization of 3D printed personalized medicine in healthcare.Keywords personalized medicine • Tumour-on-chip • 3D bioprinting • 3D printing • Cancer modelling

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“…There is a large development of textiles that integrate sensors [18], Servier and Bioserenity have launched in January 2019, Cardioskin™, a smart T-shirt which functions as a portable and wearable electrocardiogram that can monitor the heart for unlimited duration. The patient can input symptoms through a connected mobile App and that step further helps the cardiologist to correlate analysis of the data collected by the T-shirt and any related symptoms (Figure 2) [49]. Around 1.2 billion people suffer from hypertension (the main risk of heart disease and stroke) but only half diagnosed; all the system involved in detection (including digital offers) can be seen as really helpful.…”

Section: World Of Smart Wearablementioning

confidence: 99%

Health Care Digitalization, the Straightest Pathway to Personalization

Gauthier¹,

Cardot²

2021

FARMACIA

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Digitalization appears as a full mutation in the entire world, including health care. From applications (apps) to sensors, the digital is now fully integrated in daily life for patients. Monitoring treatments more easily and improving the design for drug packaging remain the most challenging points for medicines and the digitalization appears as a useful alternative. An overview of some relevant proposals that integrates personalization to users and drug forms is proposed with a specific focus on cardiology treatments and COVID-19 innovations. RezumatDigitalizarea apare ca o schimbare complexă în întreaga lume, inclusiv în sistemul sanitar. De la aplicații la senzori, digitalizarea este acum complet integrată în activitățile zilnice ale pacienților. Monitorizarea mai ușoară a tratamentelor și optimizarea designului ambalajelor pentru medicamente rămân cele mai importante provocări, iar digitalizarea este o alternativă utilă. Articolul propune o prezentare generală a unor alternative relevante care vizează personalizarea abordării terapeutice și a tipurilor de medicamente, cu accent pe tratamentele cardiologice și inovațiile apărute în contextul pandemiei COVID-19.

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Novel 3D printed device with integrated macroscale magnetic field triggerable anti-cancer drug delivery system

Cited by 16 publications

References 30 publications

3D Printing in Triggered Drug Delivery Devices: A Review

3D Printing in Triggered Drug Delivery Devices: A Review

3D Printed Personalized Medicine for Cancer: Applications for Betterment of Diagnosis, Prognosis and Treatment

Health Care Digitalization, the Straightest Pathway to Personalization

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