Novel 2‐[thio]acetamide linked quinazoline/1,2,4‐triazole/chalcone hybrids: Design, synthesis, and anticancer activity as EGFR inhibitors and apoptotic inducers
Ahmed S. Abdelkhalek,
Hend Kothayer,
Mostafa K. Soltan
et al.
Abstract:Novel triazoloquinazolines carrying the 2‐[thio]acetamide entity (4 and 5a–d) and triazoloquinazoline/chalcone hybrids incorporating the 2‐[thio]acetamide linker (8a–b and 9a–f) were developed as anticancer candidates. NCI screening of the synthesized compounds at 10 μM concentration displayed growth inhibition not only up to 99.74% as observed for 9a but also a lethal effect could be achieved as stated for compounds 9c (RPMI‐8226 and HCT‐116) and 8b, 9a, and 9e on the HCT‐116 cell line. The antiproliferative … Show more
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