Novel 18-crown-6-ether containing mono- and bisstyryl dyes derived from pyridine moiety as fluorescent dyes for non-covalent interaction with DNA

Cy3 Cyanine Dye with Strong Fluorescence Enhancement for AGRO100 and Its Derivative

“…Planar conjugated molecules with alternating single and double bonds make up cyanine dyes. Generally cyanine dyes have unique structures, such as positively charged, terminal amino groups and odd number of polymethyl chains, to the effect that they are endowed with good optical properties. − Cyanine dyes have potential applications in DNA imaging due to their high fluorescence quantum yield, good biocompatibility, and low background fluorescence. , Most of the cyanine dye fluorescent probes show weak fluorescence in common solvents but display strong fluorescence after binding to nucleic acids. , However, most of the fluorescent probes do not elaborate the mechanism in depth or only make assumptions. − Therefore, it is essential to investigate the combined mechanism in our experiments.…”

Unravelling the binding affinity and selectivity of molybdenum(ii) phenanthroline complexes with DNA G-quadruplexes by using linear-scaling DFT studies. The important role of ancillary ligands

“…2 However, its toxicity limits its use in humans. To overcome this problem, one step beyond was reached with the non-covalent binding interacting ligands, [3][4][5] where the interaction is strong enough to interrupt certain key biological processes such as DNA transcription or replication, which directly affect the growth of tumoral cells. On the other hand, an alternative and innovative strategy that is being explored during recent years to overcome the abovementioned secondary effects of toxicity for people is the use of non-canonical secondary DNA structures called G-quadruplexes (GQs), which may be used as specific targets.…”