Novel 1,3,4-oxadiazole hybrids of 3-n-butylphthalide derivatives as potential anti-ischemic stroke agents

Design and Synthesis of Novel Phthalide Derivatives containing 1,3,4‐Oxadiazole/1,2,4‐Triazole Units as Potential Antifungal Agents

“…Compounds 4 a-m and 5 a-m were synthesized according to our previous work. [21] The general method for the synthesis of compounds 6 a-g…”

“…Firstly, given that thioether and sulfoxide structures are widely present in agrochemical and pharmaceutical molecules, a series of thioether and sulfoxide substituted 1,3,4-oxadiazolephthalide derivatives (4 a-m and 5 a-m) were synthesized via etherification, hydrazinolysis, cyclization, nucleophilic substitution, and oxidation reactions with 3-butyl-6-hydroxyisobenzofuran-1(3H)-one (NBPÀ OH) as the starting material according to our previously described methods (Schemes 1). [21] Then, the compounds 7 a-g with alkyl, aryl, and heteroaryl groups directly linked to 1,3,4-oxadiazole ring were designed to investigate the influence of electronic and steric effects on biological activities. As shown in Scheme 2, intermediate 2 was reacted with acyl chloride in pyridine to get the hydrazide derivatives 6 a-g,…”