2024
DOI: 10.1002/ddr.22231
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Novel 1,3,4‐oxadiazole derivatives of naproxen targeting EGFR: Synthesis, molecular docking studies, and cytotoxic evaluation

Hiba N. Alsaad,
Baan M. AL‐Jasani,
Ammar A. Razzak Mahmood
et al.

Abstract: The close association between inflammation and cancer inspired the synthesis of a series of 1,3,4‐oxadiazole derivatives (compounds H4‐A‐F) of 6‐methoxynaphtalene. The chemical structures of the new compounds were validated utilizing Fourier‐transform infrared, proton nuclear magnetic resonance, and carbon‐13 nuclear magnetic resonance spectroscopic techniques and CHN analysis. Computer‐aided drug design methods were used to predict the compounds biological target, ADMET properties, toxicity, and to evaluate t… Show more

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