Nova metodologia de Doppler transcraniano funcional durante tarefa motora unimanual

Haratz, Salo Semelmann

doi:10.11606/t.5.2014.tde-04092014-150433

DOI: 10.11606/t.5.2014.tde-04092014-150433

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Nova metodologia de Doppler transcraniano funcional durante tarefa motora unimanual

Salo Semelmann Haratz¹

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“…The mechanism has not been elarified, but the cell membrane seems to be involved, since calcium uptake was decreased. High concentrations of lipoproteins have been reported to inhibit different lymphocyte responses markedly and the tumoricidal capacity of activated macrophages in vitro [19]. Taken together, all these observations indicate that the availability of lipoproteins in the tissues influences the immune response.…”

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confidence: 75%

The Modulatory Effect of Lipoproteins on the Release of Interleukin 1 by Human Peritoneal Macrophages Stimulated with β‐1,3‐d‐Polyglucose Derivatives

Rasmussen

Seljelid

1989

Scand J Immunol

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Human peritoneal macrophages were stimulated in vitro with beta-1,3-D-polyglucose-derivatized microbeads (GDM) or soluble aminated beta-1,3-D-polyglucose (AG) in combination with lipoproteins. The release of interleukin 1 (IL-1) was analysed in cell supernatants in a thymocyte proliferation assay. We report that the release of IL-1 is markedly enhanced in macrophages stimulated with polyglucose in either form in combination with native low-density lipoprotein (LDL) or acetyl LDL at a concentration of 100 micrograms/ml. By increasing the amount of lipoproteins up to 10-fold, the IL-1 release decreased sharply. There was only a slight increase in activity when high-density lipoprotein (HDL) or very low-density lipoprotein (VLDL) were added. Other stimulatory agents, such as gamma interferon (IFN-gamma) and lipopolysaccharide (LPS) showed about half the activity of polyglucose. There was no significant difference between native LDL and acetyl LDL in potentiating effect. Our observations also suggest that the potentiating effect of LDL or acetyl LDL is not dependent on binding to their specific receptors. These findings provide a connection between macrophages, lipoproteins, and cytokines with regard to their role in the inflammatory response.

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confidence: 75%

The Modulatory Effect of Lipoproteins on the Release of Interleukin 1 by Human Peritoneal Macrophages Stimulated with β‐1,3‐d‐Polyglucose Derivatives

Rasmussen

Seljelid

1989

Scand J Immunol

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Nova metodologia de Doppler transcraniano funcional durante tarefa motora unimanual

Cited by 1 publication

References 79 publications

The Modulatory Effect of Lipoproteins on the Release of Interleukin 1 by Human Peritoneal Macrophages Stimulated with β‐1,3‐d‐Polyglucose Derivatives

The Modulatory Effect of Lipoproteins on the Release of Interleukin 1 by Human Peritoneal Macrophages Stimulated with β‐1,3‐d‐Polyglucose Derivatives

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