Nouvelle méthode de traitement de séries de données tronquées dans l'étude de la pollution atmosphérique

Hallez, Serge; Derouane, Alain

doi:10.1016/0048-9697(82)90029-8

Cited by 9 publications

(5 citation statements)

References 5 publications

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“…Only in the case of a VOC, which has a strongly asymmetric distribution the optimal factor, did the concentration seem to be somewhat larger than 0.5. Thus, for VOC concentrations below quantification limit, they were set to 0.7 times the quantification limit, in agreement with the findings of Hallez and Derouane ( 1982 ).…”

Section: Statistical Data Treatmentsupporting

confidence: 65%

The German Environmental Survey 1990/1992 (GerES II): a representative population study

Seifert

Becker

Hoffmann

et al. 2000

J Expo Sci Environ Epidemiol

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Section: Statistical Data Treatmentsupporting

confidence: 65%

The German Environmental Survey 1990/1992 (GerES II): a representative population study

Seifert

Becker

Hoffmann

et al. 2000

J Expo Sci Environ Epidemiol

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“…In the summation, concentrations of compounds below LOQ were set at 0.7LOQ. The factor 0.7 was chosen since in the case of asymmetric distributions it is a better choice than the normally used factor 0.5 ( Hallez and Derouane, 1982 ).…”

Section: Resultsmentioning

confidence: 99%

The German Environmental Survey 1990/92 (GerES II): Sources of personal exposure to volatile organic compounds

Hoffmann

Krause

Seifert

et al. 2000

J Expo Sci Environ Epidemiol

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“…For all analyses, we used SAS software release 8.0 (SAS Institute, Cary, NC). In a first step, measurement values of the laboratory parameters (IL-1␤, TNF-␣, and CRP) below the limit of quantification (LOQ) were set at 0.7 ϫ the respective LOQ (18). Means, standard deviations, and proportions of baseline characteristics of case and control subjects were calculated.…”

Section: Methodsmentioning

confidence: 99%

Inflammatory Cytokines and the Risk to Develop Type 2 Diabetes

et al. 2003

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A subclinical inflammatory reaction has been shown to precede the onset of type 2 (non-insulin-dependent) diabetes. We therefore examined prospectively the effects of the central inflammatory cytokines interleukin (IL)-1␤, IL-6, and tumor necrosis factor-␣ (TNF-␣) on the development of type 2 diabetes. We designed a nested case-control study within the prospective population-based European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam study including 27,548 individuals. Case subjects were defined to be those who were free of type 2 diabetes at baseline and subsequently developed type 2 diabetes during a 2.3-year follow-up period. A total of 192 cases of incident type 2 diabetes were identified and matched with 384 non-disease-developing control subjects. IL-6 and TNF-␣ levels were found to be elevated in participants with incident type 2 diabetes, whereas IL-1␤ plasma levels did not differ between the groups. Analysis of single cytokines revealed IL-6 as an independent predictor of type 2 diabetes after adjustment for age, sex, BMI, waist-to-hip ratio (WHR), sports, smoking status, educational attainment, alcohol consumption, and HbA 1c (4th vs. the 1st quartile: odds ratio [OR] 2.6, 95% CI 1.2-5.5). The association between TNF-␣ and future type 2 diabetes was no longer significant after adjustment for BMI or WHR. Interestingly, combined analysis of the cytokines revealed a significant interaction between IL-1␤ and IL-6. In the fully adjusted model, participants with detectable levels of IL-1␤ and elevated levels of IL-6 had an independently increased risk to develop type 2 diabetes (3.3, 1.7-6.8), whereas individuals with increased concentrations of IL-6 but undetectable levels of IL-1␤ had no significantly increased risk, both compared with the low-level reference group. These results were confirmed in an analysis including only individuals with HbA 1c <5.8% at baseline. Our data suggest that the pattern of circulating inflammatory cytokines modifies the risk for type 2 diabetes. In particular, a combined elevation of IL-1␤ and IL-6, rather than the isolated elevation of IL-6 alone, independently increases the risk of type 2 diabetes. These data strongly support the hypothesis that a subclinical inflammatory reaction has a role in the pathogenesis of type 2 diabetes. Diabetes 52:812-817, 2003

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Nouvelle méthode de traitement de séries de données tronquées dans l'étude de la pollution atmosphérique

Cited by 9 publications

References 5 publications

The German Environmental Survey 1990/1992 (GerES II): a representative population study

The German Environmental Survey 1990/1992 (GerES II): a representative population study

The German Environmental Survey 1990/92 (GerES II): Sources of personal exposure to volatile organic compounds

Inflammatory Cytokines and the Risk to Develop Type 2 Diabetes

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