Nouveaux Décontaminants. Action Du Monoperphtalate De Magnésium (Mppm) Sur Quelques Insecticides Et Toxiques De Guerre Organophosphorées Ou Organosoufrés

Lion, Claude; Boukou-Poba, J. P.; Hedayatullah, Mir; Despagne, B.; Delmas, Gérard; Sentenac-Roumanou, H.

doi:10.1080/10426509108038086

Cited by 18 publications

(13 citation statements)

References 8 publications

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“…Svnthese des DeraCideS. Elle s'effectue de la maniere habituelle, par action de l'eau oxygenee a 30% (110 volumes) sur l'acide carboxylique correspondant (1)(2)(3)(4)8,9) dans l'acide sulfurique concentre. Afin d'eviter la decomposition des peracides, nous avons opere 5 5OC en contralant strictement la temperature, l'addition de l'eau oxygenee doit Stre tres lente.…”

Section: Resultatb -Discussionunclassified

“…Le compose 11. a ete obtenu par quaternarisation de l'amine correspondante selon la technique decrite dans la litterature(l8). 3. Svnthese des toxiaues.…”

Section: Resultatb -Discussionunclassified

“…Dans nos etudes precedentes, nous avons surtout etudie le comportement de peracides aliphatiques a longue chaine carbonee (1,2) ou aryliques (acides metachloro-et paranitroperbenzoYques, acides perphtaliques substitu&s)(l, 3,4).…”

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Nouveaux Decontaminants. Destruction De Toxiques Organophosphores Et Soufres Par l'ACIDE Monoperoxyphosphorique

Lion

Hedayatullah

Pires

et al. 1996

Phosphorus, Sulfur, and Silicon and the Related Elements

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H,PO,, monoperoxyphosphoric acid easily prepared by the reaction of H,O, with P,O, in acetonimile, is a very good decontamination agent. The destruction of toxic sulfur and phosphorus agents is completly achieved in very short time.Au cours de ces dernikres anntes, nous avons montrC que les composCs perox-ygCnts Ctaient susceptibles de dktruire rapidement et quantitativement les organophosphorks et/ou soufres toxiques. Cette rkactivitk Ctait essentiellement due au pouvoir nuclCophile vis-2-vis des organophosphorks et oxydant B 1'Cgard des composCs soufris.Les families de cornpods peroxyginks les plus actives, Ctudites dans notre laboratoire sont les peroxyacides aliphatiques IinCaires, ' alicycliques,2 aryliques3 fonctionnels ou difon~tionnels.~ Ces dries constituent actuellement d'excellents candidats B la gCnCration de solutions dkcontaminantes efficaces et non agres-*Corresponding author.

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Section: Resultatb -Discussionunclassified

“…Le compose 11. a ete obtenu par quaternarisation de l'amine correspondante selon la technique decrite dans la litterature(l8). 3. Svnthese des toxiaues.…”

Section: Resultatb -Discussionunclassified

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Nouveaux Decontaminants. Destruction De Toxiques Organophosphores Et Soufres Par l'ACIDE Monoperoxyphosphorique

Lion

Hedayatullah

Pires

et al. 1996

Phosphorus, Sulfur, and Silicon and the Related Elements

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“…A buffer was not needed. The liberation of p-nitrophenolate, in the presence of Na 2 CO 3 , as the reaction proceeded was monitored at 400 nm (3)(4)(5)7,8,10,11).…”

Section: Methodsmentioning

confidence: 99%

Catalytic destruction of paraoxon by metallomicelle layers of Co(II) and Cr(III)

Hafiz

Awadi

Badawi

et al. 2005

J Surfact & Detergents

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Two micellized ion complexes, Co(II) and Cr(III), were synthesized and found to possess good catalytic activity in cleaving the paraoxon/cobalt (chromate) complex phosphate ester. The complexes form metallomicelles, which bind the substrate by coordinating with the phosphorus in the paraoxon (which is chemically similar to the nerve agents sarin and soman). Possible reasons for the acceleration include enhanced electrophilicity of the micellized metals, enhanced surface activity, and the recognized ability of cationic micelles to accelerate the cleavage of phosphate ester. The results of kinetic data (half-lives) for paraoxon degradation were 16.5 and 28.9 min in the presence of Co(II) and Cr(III) metallomicelle layers, respectively. The higher the value of the stability constant, the more stable the Co(II) and Cr(III) complexes.Paper no. S1447 in JSD 8, 203-206 (April 2005).KEY WORDS: Catalytic destruction, Co(II) and Cr(III) metallomicelles, paraoxon, stability constant.Organophosphorus esters are used as insecticides and chemical warfare agents because of the ability of very low concentrations to inhibit the enzyme cholinesterase (1,2). Given the high toxicity of the nerve agents 1, 2, and 3 (Scheme 1), most research with phosphorolytic decontaminants utilizes models or simulants in place of these dangerous substrates. Paraoxon 4 would be a better simulant in terms of its hydrophilic/hydrophobic balance (3-6). Although fluorophosphonate nerve agents such as 2 and 3 are relatively easy to detoxify by P-F cleavage, destruction of the P-S nerve agent 1 is more difficult (7). Micellar catalysis has been extensively investigated for the past two decades; however, metallomicelles are made up of ligand surfactants and bound metal ions. The critical feature for the catalytic process is the metal cation that activates the hydroxyl nucleophile (8). Previous research on metallosurfactants includes Cu(II) (1,7-14), Zn(II) (2,8,9,15,16), Ni(II) (8,16,17), Ru(II) (18,19), and metallomicellar layers of Cu(II) and Fe(II) (20). This paper examines the effect of Co(II) and Cr(III) micellar layers on the hydrolysis of paraoxon.

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“…Dans nos etudes precedentes, nous avons surtout etudie le comportement de peracides aliphatiques a longue chaine carbonee(1,2) ou aryliques (acides metachloro-et paranitroperbenzoYques, acides perphtaliques substitu&s)(l, 3,4).…”

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Nouveaux Decontaminants. Destruction De Toxiques Organophosphores Ou Soufres Par Des Peracides Mono‐, Bi‐ Et Tricycliques Satures

Lion

Hedayatullah

Bauer

et al. 1992

Bulletin des Soc Chimique

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New peroxycarboxyclic and peroxyacetic acids have been tested for the destruction of some organophosphorus compounds and mustards. The peroxyacids used have monocyclic, bicyclic or tricyclic structures. These are very reactive against paraoxon or HD and the addition of certain surfactants enhances the reaction rate. Very short half-live times are obtained with these compounds.Nos travaux precedents sur la destruction de toxiques insecticides ou de guerre, organophosphores ou soufres, ont mis en evidence l'interet des peracides(1-4).Ces produits sont actuellement les meilleurs dgcontaminants connus, nettement supbrieurs a d'autres nuclCophiles du type hydroxymates(5) ou oximates(6). Les peracides sont en effet capables de detruire totalement les toxiques organophosphores et/ou soufres rapidement, sans aucune agressivitb, ou attaque des materiaux trait&.Rappelons par exemple que la destruction du paraoxon (0,O-diethyl 0-paranitrophenyl phosphate), insecticide bien connu permet d'obtenir avec les peracides, des produits atoxiques, la reaction se formule de la manisre suivante : RC03H + (EtO)2 -0 -6)-NO2 0 V 0-Na+ + (EtO)2 P-0-Na+

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Nouveaux Décontaminants. Action Du Monoperphtalate De Magnésium (Mppm) Sur Quelques Insecticides Et Toxiques De Guerre Organophosphorées Ou Organosoufrés

Cited by 18 publications

References 8 publications

Nouveaux Decontaminants. Destruction De Toxiques Organophosphores Et Soufres Par l'ACIDE Monoperoxyphosphorique

Nouveaux Decontaminants. Destruction De Toxiques Organophosphores Et Soufres Par l'ACIDE Monoperoxyphosphorique

Catalytic destruction of paraoxon by metallomicelle layers of Co(II) and Cr(III)

Nouveaux Decontaminants. Destruction De Toxiques Organophosphores Ou Soufres Par Des Peracides Mono‐, Bi‐ Et Tricycliques Satures

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