Notiz über die Pyrazolinreaction

An Efficient One Pot Synthesis of New Indanopyrazoline and Indanopyrazole Derivatives

“…Several methods are employed for the synthesis of pyrazolines, including the condensation of chalcones with hydrazine, hydrazine derivatives [23][24][25][26][27] and thiosemicarbazide [28] under acidic [23,24] or basic [28] conditions, and the cycloaddition of nitrilimines with carbon-carbon double bonds of a suitable dipolarophile [29][30][31][32] Pyrazoles can be easily prepared from nitrilimines and dipolarophiles bearing a carbon-carbon double or triple bonds in a two-step reaction, the subsequent oxidative heteroaromatization of pyrazolines requires drastic reaction conditions.…”

Synthesis and Characterization of New 3,5-Dinaphthyl Substituted 2-Pyrazolines and Study of Their Antimicrobial Activity

“…Among the methods employed in synthesis of pyrazolines, condensation of a variety of substituted chalcones with hydrazine and its derivatives is commonly used [ 16 , 17 , 18 ]. 2-Pyrazolines can be conveniently synthesized by the treatment of α,β-unsaturated carbonyl compounds with hydrazine reagents in basic and acidic media [ 11 , 16 , 17 ]. In this method, hydrazones are formed as intermediates, which can be subsequently cyclized to 2-Pyrazolines in the presence of a suitable cyclizing reagent like acetic acid [ 19 , 20 ].…”

Synthesis and Biological Evaluation of Novel 6-(3-(4,5-Dihydro-1,5-diphenyl-1<i>H</i>-pyrazol-3-yl)phenylamino) Pyridazin-3(2H)-one Derivatives

“…Several methods are employed in the synthesis of pyrazolines, including the condensation of chalcones with hydrazine, phenyl hydrazine [8][9][10][11][12], and condensation of chalcones with thiosemicarbazide in ethanol under strong basic or acidic conditions [13]. The desired chalcones [14] were synthesized by reacting 6-(3-acetyl-phenylamino) pyridazin-3(2H)-one with substituted aromatic aldehydes in presence of alkali.…”