Noticing pesticide spray drift from agricultural pesticide application areas and breast cancer: a case‐control study

El‐Zaemey, Sonia; Heyworth, Jane; Fritschi, Lin

doi:10.1111/1753-6405.12111

Cited by 27 publications

(9 citation statements)

References 37 publications

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“…Cytokines can act in dual ways, inhibiting tumor development or contributing to the chronic inflammation that supports tumor growth, which has been associated with poor prognosis in cancer patients [ 14 ]. Although there are associations between the risk of breast cancer and occupational exposure to pesticides [ 14 , 15 , 16 ] and its induced endocrine disruption and carcinogenesis [ 14 , 15 , 16 , 17 , 18 ], little is known about its impact on the risk stratification of patients and their tumor biology.…”

Section: Introductionmentioning

confidence: 99%

Occupational Exposure to Pesticides Affects Pivotal Immunologic Anti-Tumor Responses in Breast Cancer Women from the Intermediate Risk of Recurrence and Death

Silva

Scandolara

Kern

et al. 2022

Cancers

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Breast cancer risk stratification is a strategy based using on clinical parameters to predict patients’ risk of recurrence or death, categorized as low, intermediate, or high risk. Both low and high risk are based on well-defined clinical parameters. However, the intermediate risk depends on more malleable parameters. It means an increased possibility for either suboptimal treatment, leading to disease recurrence, or systemic damage due to drug overload toxicity. Therefore, identifying new factors that help to characterize better the intermediate-risk stratification, such as environmental exposures, is necessary. For this purpose, we evaluated the impact of occupational exposure to pesticides on the systemic profile of cytokines (IL-12, IL-4, IL-17A, and TNF-α) and oxidative stress (hydroperoxides, total antioxidants, and nitric oxide metabolites), as well as TGF-β1, CTLA-4, CD8, and CD4 expression, investigated in tumor cells. Occupational exposure to pesticides decreased the levels of IL-12 and significantly increased the expression of TGF-β1 and CTLA-4 in the immune infiltrate. Nevertheless, we observed a decrease in CTLA-4 in tumor samples and CD8 in infiltrating cells of intermediate overweight or obese patients with at least one metastatic lymph node at the diagnosis. These findings indicate that occupational exposure to pesticides changes the molecular behavior of disease and should be considered for intermediate-risk stratification assessment in breast cancer patients.

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Section: Introductionmentioning

confidence: 99%

Occupational Exposure to Pesticides Affects Pivotal Immunologic Anti-Tumor Responses in Breast Cancer Women from the Intermediate Risk of Recurrence and Death

Silva

Scandolara

Kern

et al. 2022

Cancers

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“…However, the application of pesticides potentially leads to indoor exposure amongst people living in agricultural communities, due to spray drift and the take-home pathway (Weppner et al, 2006;Chang et al, 2014;Gibbs et al, 2017;Taylor et al, 2020). Residential indoor exposure to pesticides has been associated with deleterious health effects, particularly among women and children, including an increase in risk for breast cancer, menstrual cycle disturbances, adverse birth outcomes, thyroid disorders, leukemia, non-Hodgkin lymphoma, asthma, childhood hematopoietic malignancies, autism spectrum disorders and neurodevelopmental delays following prenatal and early childhood exposure to pesticides (Alavanja et al, 1999;Ma et al, 2002;Windham et al, 2002;Farr et al, 2004;Menegaux et al, 2006;Rudant et al, 2007;El-Zaemey et al, 2013;Shelton et al, 2014;Campos and Freire, 2016;Larsen et al, 2017;Mostafalou and Abdollahi, 2017;Cherry et al, 2018;Hyland et al, 2018;Van Maele-Fabry et al, 2019;Dereumeaux et al, 2020;Chetty-Mhlanga et al, 2021). Thus, it is critically important to assess household exposures to pesticides and corresponding health risks for residents living in and around agricultural communities.…”

Section: Introductionmentioning

confidence: 99%

Indoor Air Exposure to Multiple Agricultural Pesticides Potentially Posing the Highest Risk to Young Children

Msibi

Chang

Chiang

et al. 2021

Aerosol Air Qual. Res.

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Agricultural production is a critical economic activity in many African countries, where pesticides are used extensively to improve crop yield and quality. Potential health effects resulting from indoor exposure to agricultural pesticides are very concerning and children are particularly vulnerable. This case study examined indoor exposure to and risks from agricultural pesticides. Indoor air samples were collected on spraying days from households of 15 pesticide applicators and 12 non-applicators in communities close to (~200 m) and surrounded by sugarcane fields in Eswatini (formerly Swaziland), Southern Africa. Liquid chromatography with tandem mass spectrometry (LC-MS/MS) analysis of samples revealed mean concentrations of 0.75, 0.32, 0.57 and 0.004 µg m -3 for ametryn, atrazine, pendimethalin and 2,4-dichlorophenoxyacetic acid (2,4-D), respectively, in the applicator households

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“…In humans, a case-control study including 1169 cases and 1743 controls was conducted in Canada from 2009 to 2011. During this period, a 43% increase in breast cancer risk (OR: 1.43; 95% CI: 1.15–1.78) in women indirectly exposed to pesticides was seen [15]. Another population-based case-control study identified a high risk of breast cancer development in rural populations, suggesting the importance of collecting in-depth workers’ occupational histories, as well as a detailed assessment of environmental risk factors [14].…”

Section: Introductionmentioning

confidence: 99%

Environmental Exposure to Pesticides and Breast Cancer in a Region of Intensive Agribusiness Activity in Brazil: A Case-Control Study

Silva

Campos

Mattos

et al. 2019

IJERPH

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Background: Breast cancer is a serious public health problem and is the second most prevalent cancer type in the world. The purpose of this article is to evaluate the association between pesticide use and breast cancer in a region of intense agribusiness activity in the state of Mato Grosso, Brazil. Methods: A case-control study was conducted on women living in the city of Rondonópolis, in the south of Mato Grosso state. There were 85 cases of women with confirmed breast cancer and 266 controls who were randomly selected from primary health care users. Bivariate and stratified analyses were performed. Multiple logistic regression was then performed, keeping in the final model the factors with a significance level lower than or equal to 0.05 or considered important according to apriori biological criteria. Results: In the final model, living near cropland with pesticides (OR: 2.37; CI: 95% 1.78–3.16) and women aged over 50 years who experienced early menarche (OR: 2.08; CI: 95% 1.06–4.12) had a higher risk of developing breast cancer compared to control subjects. Conclusion: This study highlights the importance of exposure to pesticides as an environmental risk factor for the development of breast cancer among women.

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Noticing pesticide spray drift from agricultural pesticide application areas and breast cancer: a case‐control study

Cited by 27 publications

References 37 publications

Occupational Exposure to Pesticides Affects Pivotal Immunologic Anti-Tumor Responses in Breast Cancer Women from the Intermediate Risk of Recurrence and Death

Occupational Exposure to Pesticides Affects Pivotal Immunologic Anti-Tumor Responses in Breast Cancer Women from the Intermediate Risk of Recurrence and Death

Indoor Air Exposure to Multiple Agricultural Pesticides Potentially Posing the Highest Risk to Young Children

Environmental Exposure to Pesticides and Breast Cancer in a Region of Intensive Agribusiness Activity in Brazil: A Case-Control Study

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