Notes

Mechanistic pathways of aromatic nucleophilic substitution in conventional solvents and ionic liquids

“…The solvent was removed under reduced pressure and the residue was purified by column chromatography on silica gel using ethyl acetate-hexane 1 : 5 to give 1.85 g of a white product (59%), mp 128-130 1C (Lit. 32…”

Quinazolines and 1,4-benzodiazepines LXXXIX: Haptens useful in benzodiazepine immunoassay development

“…The particle size of sparingly soluble drugs (drugs that are practically insoluble in aqueous fluids a t physiological pH) can affect their dissolution rate in uitro (1)(2)(3)(4)(5)(6)(7). Similarly, the rate and extent of drug absorption can be reduced in uiuo when dissolution in GI fluids is limited by particle size (2,(8)(9)(10)(11). In several cases, rank correlations were obtained between sparingly soluble drug dissolution in uitro and absorption in uiuo (12).…”

A novel synthesis of isoeugenol, [ring‐(U)‐14C]

“…Guaiacol, [ring-(U)- 14 C], 4, was produced from phenol, [ring-(U)- 14 C] using a procedure similar to ones used previously. 12,13 This procedure produced guaiacol, [ring-(U)- 14 C] in a 77.6% radiochemical yield (Scheme 1). The guaiacol, [ring-(U)- 14 C] thus produced was then esterified with propionyl chloride to give 2-methoxyphenylpropionate, [ring-(U)- 14 C], 5 (Scheme 2.).…”