2005
DOI: 10.1089/thy.2005.15.753
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Notes on the History of Cellular Uptake and Deiodination of Thyroid Hormone

Abstract: In this mini review on the history of the research devoted to thyroid hormone metabolism two pathways are discussed, i.e. uptake and subsequent deiodination in cells and tissues. In the 1950's the investigations of these processes were greatly stimulated when 131I became available for research purposes. The true nature of both mechanisms surfaced in the 1970's when it became apparent that transport of thyroid hormones into cells was a regulated carrier mediated process, while deiodination appeared to be cataly… Show more

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Cited by 12 publications
(11 citation statements)
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“…Additional mechanisms of homeostasis include autoregulation, where clearance of iodothyronines increases with their plasma levels [6466], increased degradation of TSH in hyperthyroidism [67], possible ultrashort feedback control of TRH secretion, [68] and numerous mechanisms involving control of thyroid hormone transporters and receptor density [15, 17, 6973]. Moreover, iodothyronines are subject to enterohepatic circulation that is a target of additional control signals [16, 74] and due to the prokinetic effects of iodothyronines possibly including thyroid hormones themselves [75, 76].…”
Section: Physiology Of Thyrotropic Feedback Controlmentioning
confidence: 99%
“…Additional mechanisms of homeostasis include autoregulation, where clearance of iodothyronines increases with their plasma levels [6466], increased degradation of TSH in hyperthyroidism [67], possible ultrashort feedback control of TRH secretion, [68] and numerous mechanisms involving control of thyroid hormone transporters and receptor density [15, 17, 6973]. Moreover, iodothyronines are subject to enterohepatic circulation that is a target of additional control signals [16, 74] and due to the prokinetic effects of iodothyronines possibly including thyroid hormones themselves [75, 76].…”
Section: Physiology Of Thyrotropic Feedback Controlmentioning
confidence: 99%
“…Passage of T4 may be passive, given the lipophilic nature or transporter-and energy-dependent [12]. T4 is converted to triiodothyronine (T3) by de-iodinases which are selenoproteins (type-1 and type-2 de-iodinases, D1 and D2), while T3 is degraded by type-3 de-iodinase, D3 [13].…”
Section: Th: Mechanisms Of Actionmentioning
confidence: 99%
“…Cellular passage of thyroid hormones was long thought to be passive, considering their hydrophobic nature. It is now evident that thyroid hormone uptake is both transporter and energy dependent [227] and also that intracellular thyroid An OATP family member, OATPC1, displays high affinity and allows both import and efflux for L-T 4 , but not for L-T 3 [229], which suggests that OATPC1 may be an important transporter of L-T 4 across the blood-brain barrier (BBB). As mentioned above in Section 2.4.3, MCT8 is another transporter with high affinity for L-T 4 and L-T 3 in rodents [230], while the human version is more specific for L-T 3 .…”
Section: Strategies For Achieving Pharmacologicalmentioning
confidence: 99%