Notes- Nitrogen Mustard Derivatives of Phenothiazine and Phenoxazine

AlCl3‐Catalyzed Synthesis of Triazolo[5,1‐b]thiazines

“…Moreover, sulphur containing heterocycles represent an important group of sulphur compounds that are promising due to its usefulness in practical applications. Among these heterocycles, thiazines are found to show a number of biological activities such as anti‐cancer, [3a] anti‐leukemic, [3b] anti‐bacterial [3c] and anti‐hypertensive [3d] . A literature survey discloses that there are few reports for the synthesis of triazolothiazines.…”

Synthesis, Anticancer Evaluation, and Molecular Docking Studies of Novel (4‐Hydroxy‐2‐Thioxo‐3,4‐Dihydro‐2H‐[1,3]Thiazin‐6‐Yl)‐Chromen‐2‐Ones via a Multicomponent Approach

“…On the other hand, thiazines are found to show a number of biological activities such as *Corresponding author. Email: spenta.che@nitrr.ac.in anticancer, 14 antileukemic, 15 antibacterial 16 and antihypertensive. 17 1,3-Thiazine derivatives are reported to show antibacterial, 18 antimycobacterial, 19 antiviral, 20 and pesticidal properties.…”

“…Moreover, coumarinyl dihydropyrazole was identified as a potent cytotoxic compound acting through the inhibition of telomerase and induction of apoptosis Coumarin benzothiazolehas been reported in the literature as having great biological significance as an anticancer agent. On the other hand, thiazines are found to show a number of biological activities such as anticancer, antileukemic, antibacterial and antihypertensive . 1,3‐Thiazine derivatives are reported to show antibacterial, antimycobacterial, antiviral, and pesticidal properties .…”

Potential CNS Antitumor Agents—Phenothiazines I: Nitrogen Mustard Derivatives

“…Compound I was also prepared by Shirley et ul. (13) for testing at the National Cancer Institute, but the results of the initial limited testing were not published.…”