Note on the detection of hexoestrol, stilboestrol, dienoestrol and the <i>p</i>-hydroxy metabolites of phenobarbitone and phenytoin in urine

Sl, Tompsett

doi:10.1111/j.2042-7158.1964.tb07444.x

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Alkaloids Both Macek1

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1966

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Cited by 6 publications

(1 citation statement)

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“…Specific procedures have been described for PC of sulfonamides ( (2094), filix phloroglucides (2329), negatol (1499), pentinol (2272), methvlprylon (443), V-acetyl-p-aminophenol (1826), isonicotinic acid hydrazide (101), succinylcholine (391), thalidomide (1808), and V-alkyl-6,7dimethoxyisoquinoline iodide homologs (1027).…”

Section: Alkaloids Both Macekmentioning

confidence: 99%

Chromatography

Heftmanń¹

1966

Anal. Chem.

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Section: Alkaloids Both Macekmentioning

confidence: 99%

Chromatography

Heftmanń¹

1966

Anal. Chem.

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The detection of diethylstilboestrol (DES) in urine by thin-layer chromatography

Schuller

1967

Journal of Chromatography A

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The detection of diethylstilboestrol (DES) in urine by thin-layer chromatography The use of synthetic hormones, with both an anabolic and an oestrogenic action, such as diethylstilboestrol (trassdc,a'-diethyl-4,4'-stilbenediol) has gained in popularity during the last years, especially in connection with the fattening of calves and poultry. The fact that these compounds belong to the so-called biologically highly active compounds and the presumptions expressed in literature that they possess carcinogenic or cancer-stimulating activity made several governments decide to prohibit the use of compounds with a hormonal activity for other than therapeutic purposes. Hence the detection of DES is of special interest.In The Netherlands DRYER'S~ bromimetric method and BANES AND UM-BERGER'S~~~ U.V.-irradiation method, both in a modification of Huzs IN 'T VELD*, are used for quantitative determination of DES. Besides these, need was felt for a simple specific identification method. Thin-layer chromatography turned out to be suitable for this purpose.The use of paper chromatography for the detection of DES has been described a few times. In accordance with the chemical character of DES a method based on so-called "reversed-phase" chromatography 3-s had to be developed. In view of the time-consuming character of this technique it is surprising that more attention has not --* L. G. HUIS IN

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Diethylstilbestrol Usage: Its Interesting Past, Important Present, and Questionable Future

Noller¹,

Fish²

1974

Medical Clinics of North America

118

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Note on the detection of hexoestrol, stilboestrol, dienoestrol and the p-hydroxy metabolites of phenobarbitone and phenytoin in urine

Abstract: A procedure for the identification of the synthetic oestrogens, p‐hydroxypheno‐barbitone and 5‐(p‐hydroxyphenyl) 5‐phenylhydantoin in urine by use of two dimensional paper chromatography is described.

Cited by 6 publications

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Chromatography

Chromatography

The detection of diethylstilboestrol (DES) in urine by thin-layer chromatography

Diethylstilbestrol Usage: Its Interesting Past, Important Present, and Questionable Future

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