Note on a new inbred mouse-strain GR/A

Mühlbock, O

doi:10.1016/0014-2964(65)90003-4

Cited by 83 publications

(23 citation statements)

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“…These results are in agreement with the results of direct measurement of the metabolic clearance rate of prolactin in female mice of the C3H/St and C57BL/St strains (Sinha et a/., 1979). The lowest pituitary: serum ratios were found in the GR and DD strains, of which both are of European origin, and both are characterized by the occurrence of pregnancydependent mammary tumors (Heston et al, 1964;Muhlbock, 1965). The concentrations of prolactin in these two strains during pregnancy are not known.…”

Section: Discussionsupporting

confidence: 92%

Serum, pituitary and urine concentrations of prolactin and growth hormone in eight strains of mice with varying incidence of mammary tumors

Sinha

Vlahakis

Vanderlaan

1979

Intl Journal of Cancer

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Eight inbred strains of mice with varying incidences of spontaneous mammary tumor were compared in regard to prolactin and growth hormone concentrations in sera, pituitary glands and urine. Serum prolactin was compared under basal conditions as well as after stimulation with perphenazine. Both hormones were measured with specific, homologous radioimmunoassays. Although some strains having a high incidence of mammary tumors had high levels of prolactin in sera, urine and pituitary glands, neither basal nor perphenazine-induced serum concentrations showed a consistent pattern across mouse strains that correlated with the incidence of mammary tumors. Growth hormone levels in sera, pituitary glands and urine also had no characteristic pattern that applied to all strains studied. The ratio of prolactin depleted from the pituitary gland to prolactin detected in serum after perphenazine injection, which reflected the metabolic clearance rate of prolactin, was highest in two strains with a high incidence of mammary tumors and relatively lower in low-tumor strains. These results suggest that if prolactin plays a part in mammary tumor development in mice, its mechanism varies with strains: while hyperprolactinemia may be the means in some strains, a peculiarity in the metabolism of the hormone may be more important in others.

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Section: Discussionsupporting

confidence: 92%

Serum, pituitary and urine concentrations of prolactin and growth hormone in eight strains of mice with varying incidence of mammary tumors

Sinha

Vlahakis

Vanderlaan

1979

Intl Journal of Cancer

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“…However, other types of hyperplastic lesions were noted. Plaques are found in several mouse strains, such as RIII, GR and DD (Foulds 1956;Squartini and Severi 1962;Muhlbock 1965). These lesions are pregnancy dependent lesions that will progress to pregnancy-independent growths upon recurrence or serial transplantation.…”

Section: Pathobiology Of Mammary Tumorigenesismentioning

confidence: 99%

Of Mice and Women: A Short History of Mouse Mammary Cancer Research with an Emphasis on the Paradigms Inspired by the Transplantation Method

Medina¹

2010

Cold Spring Harbor Perspectives in Biology

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The ability to transplant mammary epithelial cells of any age or developmental stage to the normal anatomical site of an inbred recipient mouse strain has revolutionized the studies of mammary development and tumor biology over the past 50 years. This simple method has made the mammary gland of the rodent one of the most accessible and studied organs and facilitated our understanding of the fundamental cellular and molecular properties of normal and neoplastic development. This short review outlines the early concepts that led to the development of the transplantation technology and the impact of this method on our understanding for a variety of processes important both for the normal development and differentiation of the gland as well as the phenomena of neoplastic progression.

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“…PDMT regresses soon after parturition regardless of the onset of lactation, and appears again at subsequent pregnancies [7,11,18,19,24,27]. The PDMT is known to transform into the pregnancyindependent autonomous mammary tumor (PIMT) after several deliveries.…”

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confidence: 99%

Metallothionein Expression and Tumor Growth in the Transplantable Pregnancy-Independent Mouse Mammary Tumor

Yamamura

Tamano

Iguchi

et al. 2001

The Journal of Veterinary Medical Science

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ABSTRACT. In various human tumors, a metal binding protein, metallothionein (MT) is reported to play an important role in carcinogenesis. In the present preliminary study, MT expression and tumor growth were investigated in transplantable pregnancy-independent mammary tumors (TPIMT) derived from pregnancy-independent mammary tumors (PIMT) in GR/A mice, in order to study the possible role of MT in mammary carcinogenesis. TPIMT as well as PIMT showed MT expression in tumor cells in all of the successive transplantations. A negative correlation was observed between MT expression in transplanted tumor tissues and their growth in the hosts (r = -0 .53, p<0.05). The present study indicates that MT is a useful marker of tumor progression in TPIMT. KEY WORDS: metallothionein, progression, transplantable pregnancy-independent mouse mammary tumor.

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Note on a new inbred mouse-strain GR/A

Cited by 83 publications

References 1 publication

Serum, pituitary and urine concentrations of prolactin and growth hormone in eight strains of mice with varying incidence of mammary tumors

Serum, pituitary and urine concentrations of prolactin and growth hormone in eight strains of mice with varying incidence of mammary tumors

Of Mice and Women: A Short History of Mouse Mammary Cancer Research with an Emphasis on the Paradigms Inspired by the Transplantation Method

Metallothionein Expression and Tumor Growth in the Transplantable Pregnancy-Independent Mouse Mammary Tumor

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