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Bailey, Kenneth C.; Hickson, W. S. E.

doi:10.1039/jr9410000145

Cited by 5 publications

(4 citation statements)

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“…Each observation consists of a sequence of four 1000‐s exposures at half‐wave plate angles of 0°, 225, 45° and 675. The data were reduced in the standard manner using the Starlink packages tsp (Bailey 1997) and figaro (Shortridge et al. 1998).…”

Section: Observationsmentioning

confidence: 99%

Spectropolarimetry of broad Hα lines in radio galaxies: constraints on the geometry of the broad-line and scattering regions

Corbett

Robinson

Axon

et al. 2002

Monthly Notices of the Royal Astronomical Society

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We present optical spectropolarimetric observations of three radio‐loud broad‐line active galactic nuclei: 3C 332, 3C 351 and 4C 73.18, together with new observations of 3C 390.3, which we observed previously. Intrinsically polarized broad Hα emission was detected in 3C 332 and 3C 390.3 at levels of ∼3 per cent and ∼1 per cent, respectively. Significant polarization was not detected in 3C 351, while the polarization measured in 4C 73.18 (∼1 per cent) is consistent with foreground contamination by the galactic interstellar medium. Although 3C 332 and 3C 390.3 both exhibit ‘double‐peaked’ broad Hα line profiles, their polarization properties differ significantly. The polarized Hα emission in 3C 332 has a similar profile to that seen in total flux and the continuum and line emission is polarized at 70° to the axis of the radio source. In 3C 390.3, however, the double peaks seen in total flux are suppressed in polarized flux and the Hα line and continuum are polarized at ∼5° to the axis of the radio emission. Comparison of these new observations of 3C 390.3 with data obtained 2 years previously reveals significant variations in both total and polarized flux. The implications of these observations for the relationship between the geometry of the broad‐line region and that of the scattering medium are discussed. We argue that models in which the Hα emission arises in a relativistically rotating disc cannot easily explain the observed polarization properties of 3C 332 and, in particular, 3C 390.3. We consider instead a model in which the line emission originates in a bipolar outflow and present calculations showing that the observed polarization properties of 3C 390.3 can be broadly explained by scattering from the inner wall of an obscuring torus, while those of 3C 332 are consistent with scattering by particles situated above the poles of the torus. We outline a scheme in which either toroidal or polar scattering dominates in a given object, depending on the orientation of its radio jet axis to our line of sight.

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Section: Observationsmentioning

confidence: 99%

Spectropolarimetry of broad Hα lines in radio galaxies: constraints on the geometry of the broad-line and scattering regions

Corbett

Robinson

Axon

et al. 2002

Monthly Notices of the Royal Astronomical Society

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“…It has been suggested that the reactivity of the acyl glucuronide was somewhat predictable from acyl glucuronide degradation, including intramolecular rearrangement. 11 An in vitro method for detecting acyl glucuronide isomers was developed by using liver microsomes and UDPGA by LC/MS/ MS. 18 However, measurement of the acyl glucuronide isomers requires adjustment of the HPLC separation and MS conditions. The in vitro trapping method presented in this report by using NAC as a trapping agent is simple and…”

Section: Identification Of Nac Adductsmentioning

confidence: 99%

“…Acyl glucuronide is an intrinsically reactive species and undergoes intramolecular rearrangement including reversible acyl migration and anomerization followed by a reaction with proteins to produce covalent adducts. 11 The postulated scheme of acyl glucuronide covalent binding to proteins is shown in Fig. 1…”

mentioning

confidence: 99%

“…are responsible for IDT (liver toxicity, etc.). [10][11][12] Conjugation with glucuronic acid is a major route of metabolism for drugs having a carboxylic acid group. Acyl glucuronide is an intrinsically reactive species and undergoes intramolecular rearrangement including reversible acyl migration and anomerization followed by a reaction with proteins to produce covalent adducts.…”

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confidence: 99%

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A liquid chromatography/tandem mass spectrometry method for detecting UGT‐mediated bioactivation of drugs as their N‐acetylcysteine adducts in human liver microsomes

Harada

Endo

Momose

et al. 2009

Rapid Comm Mass Spectrometry

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The detection of the reactive metabolites of drugs has recently been gaining increasing importance. In vitro trapping studies using trapping agents such as glutathione are usually conducted for the detection of reactive metabolites, especially those of cytochrome P450-mediated metabolism. In order to detect the UDP-glucuronosyltransferase (UGT)-mediated bioactivation of drugs, an in vitro trapping method using N-acetylcysteine (NAC) as a trapping agent followed by liquid chromatography/tandem mass spectrometry (LC/MS/MS) was developed in this study. After the test compounds (diclofenac and ketoprofen) had been incubated in human liver microsomes with uridine diphosphoglucuronic acid (UDPGA) and NAC, the NAC adducts formed through their acyl glucuronides were analyzed using LC/MS/MS with electrospray ionization (ESI). The NAC adduct showed a mass shift of 145 units as compared to its parent, and the characteristic ion fragmentations reflected the parent. This is a concise and high-throughput method for evaluating reactive metabolites by UGT-mediated bioactivation.

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Combined solvent extraction-purge and trap method for the determination of volatile organic compounds in sediments

Amaral

Olivella

Grimalt

et al. 1994

Journal of Chromatography A

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Cited by 5 publications

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Spectropolarimetry of broad Hα lines in radio galaxies: constraints on the geometry of the broad-line and scattering regions

Spectropolarimetry of broad Hα lines in radio galaxies: constraints on the geometry of the broad-line and scattering regions

A liquid chromatography/tandem mass spectrometry method for detecting UGT‐mediated bioactivation of drugs as their N‐acetylcysteine adducts in human liver microsomes

Combined solvent extraction-purge and trap method for the determination of volatile organic compounds in sediments

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