Notch3 and Jagged2 contribute to gastric cancer development and to glandular differentiation associated with MUC2 and MUC5AC expression

Kang, Haeyoun; An, Hee-Jung; Song, Ji‐Hyun; Kim, Tae-Heon; Heo, Jin Hyung; Ahn, Dae-Ho; Kim, Gwangil

doi:10.1111/j.1365-2559.2012.04274.x

Cited by 50 publications

(42 citation statements)

References 31 publications

(64 reference statements)

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“…However, the present data demonstrated that Notch 3 is (8,9,13). The mechanism of this phenomenon and how Notch 3 exerts its function in NSCLC remain unclear and require further research.…”

Section: Discussionmentioning

confidence: 84%

“…In hematological malignancies, the role for Notch is well established, while more recent studies have demonstrated the significance of Notch activity in the initiation and progression of solid tumors (5)(6)(7)(8)(9). The mammalian Notch receptor family consists of four type I transmembrane receptors (known as Notch 1-4), all of which have been implicated in human cancer.…”

Section: Introductionmentioning

confidence: 99%

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Notch signaling molecules as prognostic biomarkers for non-small cell lung cancer

Jin

Qian³

et al. 2015

Oncology Letters

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“…However, the present data demonstrated that Notch 3 is (8,9,13). The mechanism of this phenomenon and how Notch 3 exerts its function in NSCLC remain unclear and require further research.…”

Section: Discussionmentioning

confidence: 84%

Section: Introductionmentioning

confidence: 99%

Notch signaling molecules as prognostic biomarkers for non-small cell lung cancer

Jin

Qian³

et al. 2015

Oncology Letters

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“…In gastric cancer cells, Notch1 and Notch2 pathways have been shown to promote tumorigenesis [4, 5]. Furthermore, Notch3 receptor expression was associated with gastric cancer development [6] and Notch4 receptor promoted gastric cancer growth [7]. …”

Section: Introductionmentioning

confidence: 99%

Notch1 pathway-mediated microRNA-151-5p promotes gastric cancer progression

et al. 2016

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Gastric carcinoma is the third leading cause of lethal cancer worldwide. Previous studies showed that Notch1 receptor intracellular domain (N1IC), the activated form of Notch1 receptor, promotes gastric cancer progression. It has been demonstrated that a significant cross-talk interplays between Notch pathways and microRNAs (miRNAs) in controlling tumorigenesis. This study identified an intronic microRNA-151 (miR-151), which consists of two mature miRNAs, miR-151-3p and miR-151-5p, as a Notch1 receptor-induced miRNA in gastric cancer cells. Activation of Notch1 pathway enhanced expressions of miR-151 and its host gene, focal adhesion kinase (FAK), in gastric cancer cells. The levels of miR-151 in gastric cancer samples were higher than those of adjacent non-tumor samples. Activated Notch1 pathway induced CBF1-dependent FAK promoter activity. The ectopic expression of miR-151 promoted growth and progression of SC-M1 gastric cancer cells including cell viability and colony formation, migration, and invasion abilities. Activated Notch1 pathway could augment progression of gastric cancer cells through miR-151-5p and FAK. The mRNA levels of pluripotency genes, Nanog and SOX-2, tumorsphere formation ability, tumor growth, and lung metastasis of SC-M1 cells were elevated by activated Notch1 pathway through miR-151-5p. Furthermore, miR-151-5p could target 3′-untranslated region (3′-UTR) of p53 mRNA and down-regulate p53 level in SC-M1 cells. Mechanistically, Notch1/miR-151-5p axis contributed to progression of SC-M1 cells through down-regulation of p53 which in turn repressed FAK promoter activity. Taken together, these results suggest that Notch1 pathway and miR-151-5p interplay with p53 in a reciprocal regulation loop in controlling gastric carcinogenesis.

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“…In addition, in patients with HCC an epithelial gene signature has been associated with sensitivity to the epidermal growth factor receptor inhibitors gefitinib and cetuximab (65). Deregulated expression of Notch, including the overexpression and activation of Notch proteins, ligands and targets, has been identified in numerous solid tumors, including cervical, endometrial, renal, lung and gastric carcinomas (66). These findings suggest that additional signaling pathways may affect whether Notch functions as a tumor suppressor or oncogene in a particular tissue (67).…”

Section: Role Of Notch In Hcc and Icc Developmentmentioning

confidence: 93%

Oncogenic role of the Notch pathway in primary liver cancer

et al. 2016

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Abstract. Primary liver cancer, which includes hepatocellular carcinoma (HCC), intrahepatic cholangiocarcinoma (ICC) and fibrolamellar HCC, is one of the most common malignancies and the third leading cause of cancer-associated mortality, worldwide. Despite the development of novel therapies, the prognosis of liver cancer patients remains extremely poor. Thus, investigation of the genetic background and molecular mechanisms underlying the development and progression of this disease has gained significant attention. The Notch signaling pathway is a crucial determinant of cell fate during development and disease in several organs. In the liver, Notch signaling is involved in biliary tree development and tubulogenesis, and is also significant in the development of HCC and ICC. These findings suggest that the modulation of Notch pathway activity may have therapeutic relevance. The present review summarizes Notch signaling during HCC and ICC development and discusses the findings of recent studies regarding Notch expression, which reveal novel insights into its function in liver cancer progression.

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Notch3 and Jagged2 contribute to gastric cancer development and to glandular differentiation associated with MUC2 and MUC5AC expression

Abstract: The expression of Notch3 and Jagged2 is associated not only with gastric cancer development but also with the intestinal/glandular differentiation of gastric carcinoma cells, suggesting a role as a possible favourable prognostic indicator.

Cited by 50 publications

References 31 publications

Notch signaling molecules as prognostic biomarkers for non-small cell lung cancer

Notch signaling molecules as prognostic biomarkers for non-small cell lung cancer

Notch1 pathway-mediated microRNA-151-5p promotes gastric cancer progression

Oncogenic role of the Notch pathway in primary liver cancer

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