Notch1 regulates the JNK signaling pathway and increases apoptosis in hepatocellular carcinoma

Sui, Chengxu; Zhuang, Chengjun; Sun, Da; Yang, Li; Zhang, Liang; Song, Lei

doi:10.18632/oncotarget.17434

Cited by 24 publications

(23 citation statements)

References 30 publications

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“…CXCR4 is a transmembrane G-coupled receptor acting via binding to its CXC motif ligand 12 (CXCL12) (Hajinejad et al, 2017;Khanlarkhani et al, 2017;Omidi et al, 2015Omidi et al, , 2017. Notch1 increases apoptosis in HCC cells via activation JNK (Sui et al, 2017). However, evidence for possible implication of melatonin on these signaling pathways for HCC is too poor.…”

Section: Other Signaling Pathwaysmentioning

confidence: 99%

Human hepatocellular carcinoma: Protection by melatonin

Mortezaee

2018

Journal Cellular Physiology

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Despite great scientific breakthroughs toward understanding the identity of human hepatocellular carcinoma (HCC) mechanistically, there are still no clinically efficient therapeutic methods for this cancer. Melatonin (N-acetyl-5-methoxytryptamine) is a multi-tasking hormone that has long been known for its anti-cancer activity against various human cancers including HCC, which is a focus of this review. PubMed database was searched for relevant articles with the keywords: hepatocellular carcinoma (HCC), melatonin, apoptosis, proliferation, invasion, angiogenesis, autophagy, oxidative stress, tumor immunity, and mitogen-activated protein kinase (MAPK) focusing on just human cell lines and English language articles. Melatonin inhibits apoptosis resistance and activates both extrinsic and intrinsic pathways of apoptosis in HCC. Melatonin induces ensoplasmic reticulum (ER)- and autophagy-mediated apoptosis in cancer cells. Melatonin works against cancer cell proliferation, motility, and invasiveness by modulating actions of a variety of transcription factors and related pathways. Melatonin also relieves an immunosuppressive state in HCC cancer cells through making a control over tumor-derived exosomes. Both pro-and anti-oxidative functions of melatonin are necessary for combating HCC. Combination of melatonin with chemotherapy could also provide cumulative effects on cancer cells. Melatonin exerts most of these roles by acting on the members of MAPK family.

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Section: Other Signaling Pathwaysmentioning

confidence: 99%

Human hepatocellular carcinoma: Protection by melatonin

Mortezaee

2018

Journal Cellular Physiology

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“…Another circRNA, hsa_circ_0005986, was also down-regulated in HCC tissues and HCC cell lines, and its lower expression was correlated with chronic hepatitis B family history, tumor diameters, microvascular invasion and Barcelona Clinic Liver Cancer (BCLC) stage 27 . Further studies demonstrated that knocking down of hsa_circ_0005986 increased miR-129-5p levels, leading to reduced expression of its target gene Notch homolog 1(NOTCH1), a receptor which plays an important role in HCC carcinogenesis and metastasis 27 , 51 - 54 . However, knocking down of miR-129-5p significantly promoted, while over-expression of this miRNA greatly inhibited, the expression of hsa_circ_0005986 and NOTCH1 27 .…”

Section: Down-regulated Circrnas In Hccmentioning

confidence: 99%

The Emerging Role of Circular RNAs in Hepatocellular Carcinoma

Qiu¹,

Wu²,

Yu³

et al. 2018

J. Cancer

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Hepatocellular carcinoma (HCC) ranks the third leading cause of cancer death in the world and has a notably low survival rate. Circular RNAs (circRNAs) are newly classed non-coding RNA (ncRNA) members that are capable of regulating gene expression at transcription or post-transcription levels. Recent studies demonstrate that some circRNAs are differentially expressed in HCC, and the deregulation of these circRNAs is associated with the clinical pathological and prognostic significance. They also play essential roles in HCC progression, and contribute to cell proliferation, migration, invasion and metastasis by targeting different microRNAs (miRNAs) and protein-coding genes. In this review, we concentrate on recent progress of some important circRNAs in HCC, with an emphasis on their deregulation, functions and regulatory mechanisms, and discuss their potential utility as diagnostic and/or prognostic biomarkers or therapeutic targets for HCC.

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“…The activation of NOTCH1 has been widely shown to be correlated with mammary tumorigenesis in animal models, and the upregulation of Notch receptors has been frequently observed in many cancer types. Furthermore, NOTCH1 has been shown to promote metastasis in many cancer types, including RCC, liver cancer, head and neck cancer, and gastric cancer [26][27][28][29]. It correlated with the formation of vasculogenic mimicry (VM) and the expression of epithelial-to-mesenchymal transition (EMT) biomarkers to be involved in the process of tumor metastasis [30,31].…”

Section: Discussionmentioning

confidence: 99%

CircPDK1 promotes RCC cell migration and invasion through the miR-377-3p/NOTCH1 axis

Huang¹,

Ding²,

Zhang³

et al. 2020

Preprint

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Circular RNAs (circRNAs) are novel clusters of endogenous noncoding RNAs (ncRNAs) that are widely expressed in various tissue types. Recent studies have indicated that circRNAs involved in multiple tumorigenesis processes, and the potential significance of circRNAs remains to be explored. However, the roles roles and underlying mechanisms of circRNAs in clear cell renal cell carcinoma (RCC) remain unclear. We found that CircPDK1 is highly expressed in RCC by circRNA-seq assay. Moreover, the functional enrichment experiments showed that CircPDK1 is significantly associated with RCC metastasis. Eighty pairs of clinical samples were analyzed, and the results showed a correlation between CircPDK1 and lymph node and distant organ metastases in RCC. RNA-sequencing following knockdown of CircPDK1 revealed significant changes in the expression of many molecules in the metastasis-associated pathway. After bioinformatics prediction, we verified the relationships between CircPDK1 and miR-377-3p and between miR-377-3p and NOTCH1 by a luciferase reporter assay. Furthermore, the effect of CircPDK1 on RCC metastasis can be functionally influenced by miR-377-3p and NOTCH1. Altogether, our study shows that the CircPDK1 - miR-377-3p - NOTCH1 axis plays an important role in RCC metastasis, suggests CircPDK1 might serve as a potential therapeutic target for RCC treatment.

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Notch1 regulates the JNK signaling pathway and increases apoptosis in hepatocellular carcinoma

Cited by 24 publications

References 30 publications

Human hepatocellular carcinoma: Protection by melatonin

Human hepatocellular carcinoma: Protection by melatonin

The Emerging Role of Circular RNAs in Hepatocellular Carcinoma

CircPDK1 promotes RCC cell migration and invasion through the miR-377-3p/NOTCH1 axis

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