Notch1 is required in newly postmitotic cells to inhibit the rod photoreceptor fate

Mizeracka, Karolina; DeMaso, Christina R.; Cepko, Constance L.

doi:10.1242/dev.090696

Cited by 68 publications

(85 citation statements)

References 58 publications

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“…3A,B). For photoreceptors, as noted above, one of the earliest signs of this transition is Otx2 expression; inhibition of Notch signaling causes the induction of Otx2 expression in most progenitors of the mouse retina (Jadhav et al, 2006;Nelson et al, 2006Nelson et al, , 2007Yaron et al, 2006), while conditional deletion of Notch pathway components reduces the number of progenitors and increases the number of both rod and cone photoreceptor precursors (Jadhav et al, 2006;Yaron et al, 2006;Riesenberg et al, 2009;Mizeracka et al, 2013). There are at least three non-exclusive ways that Notch signaling might inhibit photoreceptor genesis: (1) by controlling the fraction of progenitors that exit the cell cycle at any given point during development; (2) by regulating photoreceptor potential (i.e.…”

Section: Signaling Molecules Involved In Photoreceptor Fate Specificamentioning

confidence: 88%

Photoreceptor cell fate specification in vertebrates

2015

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Photoreceptors -the light-sensitive cells in the vertebrate retinahave been extremely well-characterized with regards to their biochemistry, cell biology and physiology. They therefore provide an excellent model for exploring the factors and mechanisms that drive neural progenitors into a differentiated cell fate in the nervous system. As a result, great progress in understanding the transcriptional network that controls photoreceptor specification and differentiation has been made over the last 20 years. This progress has also enabled the production of photoreceptors from pluripotent stem cells, thereby aiding the development of regenerative medical approaches to eye disease. In this Review, we outline the signaling and transcription factors that drive vertebrate photoreceptor development and discuss how these function together in gene regulatory networks to control photoreceptor cell fate specification.

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Section: Signaling Molecules Involved In Photoreceptor Fate Specificamentioning

confidence: 88%

Photoreceptor cell fate specification in vertebrates

2015

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“…Notch, and its downstream effector, the bHLH transcription factor Hes, are important for retinal morphogenesis, progenitor cell maintenance, cell fate determination and specification in the retina (Bao and Cepko, 1997; Henrique et al, 1997; Jadhav et al, 2006; Maurer et al, 2014; Mizeracka et al, 2013; Nelson et al, 2006; Ohtsuka et al, 1999). Sox4 and Sox11 regulate neuronal differentiation in the developing cortex through regulating their targets NeuroD1 and Tbr2 (Chen et al, 2015).…”

Section: Discussionmentioning

confidence: 99%

SoxC Transcription Factors Promote Contralateral Retinal Ganglion Cell Differentiation and Axon Guidance in the Mouse Visual System

Kuwajima

Soares

Sitko

et al. 2017

Neuron

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Summary Transcription factors control cell identity by regulating diverse developmental steps such as differentiation and axon guidance. The mammalian binocular visual circuit is comprised of projections of retinal ganglion cells (RGCs) to ipsilateral and contralateral targets in the brain. A transcriptional code for ipsilateral RGC identity has been identified, but less is known about the transcriptional regulation of contralateral RGC development. Here we demonstrate that SoxC genes (Sox4, 11, and 12) act on the progenitor-to-postmitotic transition to implement contralateral, but not ipsilateral, RGC differentiation, by binding to Hes5 and thus repressing Notch signaling. When SoxC genes are deleted in postmitotic RGCs, contralateral RGC axons grow poorly on chiasm cells in vitro, project ipsilaterally at the chiasm midline in vivo, and Plexin-A1 and Nr-CAM expression in RGCs is downregulated. These data implicate SoxC transcription factors in the regulation of contralateral RGC differentiation and axon guidance.

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“…The increasing availability of transcriptomic technologies within the last decade has facilitated high-throughput identification of gene expression profiles that define distinct cell types (Trimarchi et al, 2007; Okaty et al, 2011; Goetz and Trimarchi, 2012; Mizeracka et al, 2013; Islam et al, 2014; Sümbül et al, 2014; Macosko et al, 2015; Molyneaux et al, 2015; Mullally et al, 2016; Shima et al, 2016). Here we have applied DNA microarray analysis to RGCs projecting ipsilaterally and contralaterally during embryonic development.…”

Section: Discussionmentioning

confidence: 99%