Notch signalling in the regulation of peripheral T-cell function

McKenzie, Grahame J.; Young, Lesley; Briend, Emmanuel; Lamb, Jonathan R.; Dallman, Margaret J.; Champion, Brian

doi:10.1016/s1084-9521(02)00181-7

Cited by 19 publications

(22 citation statements)

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“…We next checked the T-cell populations in the spleen because the Notch pathway is known to influence peripheral T-cell development and activation (1,7,29). In particular, Deltex-1 was recently shown to be constitutively expressed in human CD4 ϩ CD25 ϩ regulatory T cells and downregulated after activation of these cells with anti-CD3 (31 (Fig.…”

Section: Generation Of a Mouse Strain Lacking The Deltex-1 Ring Fingementioning

confidence: 99%

“…Gain-of-function experiments suggested that Notch-1 might similarly influence the CD4 ϩ /CD8 ϩ lineage decision (40), but a conditional inactivation of RBP-J did not alter the CD4/CD8 ratio (46). Lastly, new data point to a potential function of the Notch pathway in the regulation of peripheral T-cell activation (7) and the development of regulatory T cells (reviewed in reference 29). A role for the Notch pathway in B-cell development was recently discovered.…”

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confidence: 99%

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Normal Immune System Development in Mice Lacking the Deltex-1 RING Finger Domain

Storck

Delbos

Städler

et al. 2005

Molecular and Cellular Biology

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The Notch signaling pathway controls several cell fate decisions during lymphocyte development, from T-cell lineage commitment to the peripheral differentiation of B and T lymphocytes. Deltex-1 is a RING finger ubiquitin ligase which is conserved from Drosophila to humans and has been proposed to be a regulator of Notch signaling. Its pattern of lymphoid expression as well as gain-of-function experiments suggest that Deltex-1 regulates both B-cell lineage and splenic marginal-zone B-cell commitment. Deltex-1 was also found to be highly expressed in germinal-center B cells. To investigate the physiological function of Deltex-1, we generated a mouse strain lacking the Deltex-1 RING finger domain, which is essential for its ubiquitin ligase activity. Deltex-1 ⌬/⌬ mice were viable and fertile. A detailed histological analysis did not reveal any defects in major organs. T-and B-cell development was normal, as were humoral responses against T-dependent and T-independent antigens. These data indicate that the Deltex-1 ubiquitin ligase activity is dispensable for mouse development and immune function. Possible compensatory mechanisms, in particular those from a fourth Deltex gene identified during the course of this study, are also discussed.

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Section: Generation Of a Mouse Strain Lacking The Deltex-1 Ring Fingementioning

confidence: 99%

mentioning

confidence: 99%

Normal Immune System Development in Mice Lacking the Deltex-1 RING Finger Domain

Storck

Delbos

Städler

et al. 2005

Molecular and Cellular Biology

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“…The role of Notch signaling in early B and T lymphocyte development has been extensively studied [7,8], while its influence on mature T cell function only recently emerged (review in Ref. [9]). It was recently shown that each ligand of Delta and Jagged family could exert specific effects on T cell development and maturation.…”

Section: Specific Effects Exerted By Notch Ligandsmentioning

confidence: 99%

Notch signaling: Distinct ligands induce specific signals during lymphocyte development and maturation

Coste

Freitas

2006

Immunology Letters

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“…These are notch 4 receptor, the gap junction protein connexin 40, and the adenosine receptor. Notch is a developmental gene that has been recently implicated in the development of human lymphocytes (McKenzie et al, 2003). Interestingly, there is a demonstrated link between the notch receptor and at least two actin-binding proteins (Zhang et al, 1998).…”

Section: Biological Findingsmentioning

confidence: 99%

Bayesian Variable Selection in Multinomial Probit Models to Identify Molecular Signatures of Disease Stage

et al. 2004

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Here we focus on discrimination problems where the number of predictors substantially exceeds the sample size and we propose a Bayesian variable selection approach to multinomial probit models. Our method makes use of mixture priors and Markov chain Monte Carlo techniques to select sets of variables that differ among the classes. We apply our methodology to a problem in functional genomics using gene expression profiling data. The aim of the analysis is to identify molecular signatures that characterize two different stages of rheumatoid arthritis.

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Notch signalling in the regulation of peripheral T-cell function

Cited by 19 publications

References 50 publications

Normal Immune System Development in Mice Lacking the Deltex-1 RING Finger Domain

Normal Immune System Development in Mice Lacking the Deltex-1 RING Finger Domain

Notch signaling: Distinct ligands induce specific signals during lymphocyte development and maturation

Bayesian Variable Selection in Multinomial Probit Models to Identify Molecular Signatures of Disease Stage

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