Notch Signaling in Skeletal Development, Homeostasis and Pathogenesis

Zieba, Jennifer; Chen, Yi-Ting; Lee, Brendan; Bae, Yangjin

doi:10.3390/biom10020332

Cited by 51 publications

(49 citation statements)

References 108 publications

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“…The Notch signaling pathway is an evolutionarily conserved intercellular signaling pathway [ 52 ], which plays an important role in the regulation of cell differentiation and cell fate and participates in the regulation of adult stem cell differentiation [ 52 , 53 ]. This pathway has been shown to play a key role in the proliferation and osteogenic differentiation of stem cells [ 54 , 55 ].…”

Section: Resultsmentioning

confidence: 99%

Simultaneous incorporation of PTH(1–34) and nano-hydroxyapatite into Chitosan/Alginate Hydrogels for efficient bone regeneration

Zou

Wang

Zhou

et al. 2021

Bioactive Materials

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Tissue regeneration based on the utilization of artificial soft materials is considered a promising treatment for bone-related diseases. Here, we report cranial bone regeneration promoted by hydrogels that contain parathyroid hormone (PTH) peptide PTH(1–34) and nano-hydroxyapatite (nHAP). A combination of the positively charged natural polymer chitosan (CS) and negatively charged sodium alginate led to the formation of hydrogels with porous structures, as shown by scanning electron microscopy. Rheological characterizations revealed that the mechanical properties of the hydrogels were almost maintained upon the addition of nHAP and PTH(1–34). In vitro experiments showed that the hydrogel containing nHAP and PTH(1–34) exhibited strong biocompatibility and facilitated osteogenic differentiation of rat bone marrow mesenchymal stem cells (rBMSCs) via the Notch signaling pathway, as shown by the upregulated expression of osteogenic-related proteins. We found that increasing the content of PTH(1–34) in the hydrogels resulted in enhanced osteogenic differentiation of BMSCs. Implantation of the complex hydrogel into a rat cranial defect model led to efficient bone regeneration compared to the rats treated with the hydrogel alone or with nHAP, indicating the simultaneous therapeutic effect of nHAP and PTH during the treatment process. Both the in vitro and in vivo results demonstrated that simultaneously incorporating nHAP and PTH into hydrogels shows promise for bone regeneration, suggesting a new strategy for tissue engineering and regeneration in the future.

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Section: Resultsmentioning

confidence: 99%

Simultaneous incorporation of PTH(1–34) and nano-hydroxyapatite into Chitosan/Alginate Hydrogels for efficient bone regeneration

Zou

Wang

Zhou

et al. 2021

Bioactive Materials

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show abstract

“…Notch signaling pathway consists of ligands, Notch receptors, and CSL (CBF-1, Suppressor of hairless, LAG) proteins, and it can regulate chondrocyte proliferation and differentiation via the interaction of the adjacent cells (Zieba et al, 2020). After the ligand binds to the receptor, the Notch signaling is activated, which causes the cleavage of extracellular domain of receptor.…”

Section: Proper Notch Signaling Is Vital For Chondrogenesis and Normal Chondrocyte Differentiation Via Modulating Key Regulatory Factors mentioning

confidence: 99%

Molecular Mechanisms of Chondrocyte Proliferation and Differentiation

Chen

Tan

Shou-song

et al. 2021

Front. Cell Dev. Biol.

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Cartilage is a kind of connective tissue that buffers pressure and is essential to protect joint movement. It is difficult to self-recover once cartilage is damaged due to the lack of blood vessels, lymph, and nerve tissues. Repair of cartilage injury is mainly achieved by stimulating chondrocyte proliferation and extracellular matrix (ECM) synthesis. Cartilage homeostasis involves the regulation of multiple growth factors and the transduction of cellular signals. It is a very complicated process that has not been elucidated in detail. In this review, we summarized a variety of signaling molecules related to chondrocytes function. Especially, we described the correlation between chondrocyte-specific regulatory factors and cell signaling molecules. It has potential significance for guiding the treatment of cartilage injury.

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“…As the disease progresses, bone cell-mediated bone remodeling would be emerging, with reducing bone mass, damaging bone microstructure, and leading to osteoporosis. [ 1 ] With the aggravation of the current aging society, the incidence of osteoporosis in the elderly is also increasing year by year. [ 2 ] Due to the deterioration of physical movement of the elderly, walking is unstable, and patients are prone to falls or collisions, and often accompanied by fractured ankle.…”

Section: Introductionmentioning

confidence: 99%

Vitamin B6 as a novel risk biomarker of fractured ankles

Zhang

Wan

et al. 2021

Medicine

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Ankle fractures are the most common intra-articular fractures. Osteoporosis is a common and frequent disease among the elderly with a poor prognosis and high risk of fractured ankles. However, the relationship between vitamin B6 and the incidence of fractured ankles in patients with osteoporosis is unclear. A total of 101 patients with osteoporosis were recruited. Clinical and followed-up information was recorded. And the vitamin B6, albumin, globulin, and hemoglobin in the blood were tested. Pearson's chi-squared and spearman test were performed to analyze the correlation between fractured ankles and relative parameters. Univariate and multivariate logistic regression, receiver operating characteristic curve analysis, univariate and multivariate Cox proportional hazards regression analysis, and Kaplan–Meier method were also performed. There exist strong relation between the expression level of vitamin B6 and fractured ankle ( P < .001). The expression of vitamin B6 [Odd ratio (OR) = 12.071, 95% confidence interval (CI): 4.69–31.143, P < .001] has a clear correlation with whether the patients have fractured ankles via the univariate logistic regression analysis. In terms of multivariate logistic regression level, vitamin B6 (OR = 15.384, 95% CI:5.195–45.556, P < .001) was significantly associated with fractured ankle. In addition, expression level of vitamin B6 [hazard ratio (HR) = 11.684, 95% CI: 6.419–21.267, P < .001] was significantly associated with Maintenance time from recovery to recurrence (MRTT) of patients with osteoporosis. Enhanced vitamin B6 is significantly correlated with the poor prognosis of patients with osteoporosis and the increasing incidence of fractured ankles.

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Notch Signaling in Skeletal Development, Homeostasis and Pathogenesis

Cited by 51 publications

References 108 publications

Simultaneous incorporation of PTH(1–34) and nano-hydroxyapatite into Chitosan/Alginate Hydrogels for efficient bone regeneration

Simultaneous incorporation of PTH(1–34) and nano-hydroxyapatite into Chitosan/Alginate Hydrogels for efficient bone regeneration

Molecular Mechanisms of Chondrocyte Proliferation and Differentiation

Vitamin B6 as a novel risk biomarker of fractured ankles

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