Notch receptors and hematopoiesis

Kojika, Satoru; Griffin, James D.

doi:10.1016/s0301-472x(01)00676-2

Cited by 117 publications

(88 citation statements)

References 150 publications

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“…In addition, a higher proportion of total immature memory CD8 + and CD4 + T cells are associated with improved prognosis in chronic HIV-1 infection (54) and can be enriched in the absence of viremia and immune activation in treated HIV-1-positive individuals (55). Interestingly, we found evidence that Notch signaling, previously mostly shown to regulate hematopoietic and thymic precursor cell differentiation (37,38), is also involved in regulating the transition of long-lasting PD-1 lo into short-lived PD-1 hi Tfh-like cells. This suggest that stem cell pathways, previously recognized in the context of traditional organ-specific stem cells, may also contribute to regulation and fate decisions within the memory Tfh pools, and may offer molecular targets for selectively influencing memory Tfh development.…”

Section: Cxcr3mentioning

confidence: 70%

“…To investigate mechanisms that may dictate the ability of PD-1 lo pTfh cells to repopulate PD-1 hi pTfh cells, we focused on the Notch signaling cascade, which has previously been implicated in regulating the developmental fate of organ-specific stem cells (37,38), memory T cells (39)(40)(41), and T follicular helper cells (42). We observed that Notch receptors 2 and 4, as well as the Notch active intracellular domain, were upregulated on CXCR5 + T cells after 6 days of coculture with autologous B cells and SEB in the presence of GSI compared with DMSO (n = 6).…”

Section: Cd95mentioning

confidence: 99%

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Circulating CXCR5+CXCR3+PD-1lo Tfh-like cells in HIV-1 controllers with neutralizing antibody breadth

et al. 2017

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Section: Cxcr3mentioning

confidence: 70%

Section: Cd95mentioning

confidence: 99%

Circulating CXCR5+CXCR3+PD-1lo Tfh-like cells in HIV-1 controllers with neutralizing antibody breadth

et al. 2017

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“…A number of in vivo and in vitro studies have demonstrated the roles of the Notch signaling pathway in stem cells, early progenitor cells and in the development of cancers. The involvement of Notch signaling in cancer was first identified in T-cell acute lymphoblastic leukemia (T-ALL) where chromosomal translocation (7;9) leads to the constitutive activation of Notch signaling (23)(24)(25)(26) that was further demonstrated in a mouse model where expression of a constitutively active Notch1 protein led to the development of T-cell lymphoma (27,28).…”

Section: Signaling Pathways In Cancer Stem Cellsmentioning

confidence: 99%

Cancer stem cells - from initiation to elimination, how far have we reached? (Review)

Akhtar

Bussen²,

Scott³

2009

Int J Oncol

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Abstract. Cancer stem cells (CSCs) are rare tumor cells that have the potential to proliferate, self-renew and induce tumorigenesis. Over the past few years, CSCs have been isolated from several different tumors and when implanted into immune-deficient mice, generate tumors that are identical to the parental tumors. In this review, we summarize the current literature on CSCs, which suggests that since these cells have the ability to drive tumor formation, specifically targeting them may lead to more effective therapies against tumors.

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“…Notch signaling pathway plays an important role in myelosuppression restoration and is capable of adjusting various stages of hematopoietic cells [6][7]. Notch receptors and ligands are highly expressed in hematopoietic progenitor cells and marrow stromal cells [8].…”

Section: Introductionmentioning

confidence: 99%

Study on Acupuncture and Moxibustion of the Notch Signaling Pathway in Bone Marrow Cells to Alleviate Cyclophosphamide-Induced Myelosuppression in Mice

Lü¹,

Teng²,

Cao³

et al. 2016

J Alt Med Res

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Objective: To evaluate the protein expression and distribution of Notch signaling-related, differentially expressed genes (DEGs) in the bone marrow cells of mice. Additionally, verification of acupuncture regulated protein expression of these DEGs to protect bone marrow stem cells and alleviate cyclophosphamide (CTX) chemotherapy-induced myelosuppression was examined as well.Methods: Thirty two Healthy male Kunming mice of clean grade were randomized into blank group (A), model group (B), acupuncture group (C) and moxibustion group (D). Mice in groups B, C, and D were intraperitoneally injected with 100mg/kg/d CTX for three successive days to generate the myelosuppressive model; while mice in group A were injected with an equivalent volume of sterile saline. After immobilizing the animals, mice in groups C and D received daily acupuncture and moxibustion in points "DU14", "BL17" " BL23" and " ST36"respectively,while those in group A and B were received no treatment. After five days of treatment,the mice were euthanized by cervical dislocation and their femurs collected for marrow harvest , Small-throughput cDNA microarray was used for initial DEG screening, followed by immunohistochemistry, realtime quantitative PCR (RT-qPCR), and Western Blot analysis to detect protein expression and quantity of the Notch signaling-related DEGs in the bone marrow cells.Results: Expression of numb proteins (i.e., numb1 and numb2) was found to be upregulated while notch2 and jag1 were down regulated in bone marrow cells of acupuncture-treated, tumor-bearing mice.Conclusion: Notch signaling pathway serves as an important signal transduction pathway for acupuncture and moxibustion to relieve CTX chemotherapy-induced myelosuppression. Regulation of associated DEGs in notch signaling pathway in marrow cells is the key mechanism by which acupuncture and moxibustion improve marrow hematopoiesis after chemotherapy.

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Notch receptors and hematopoiesis

Cited by 117 publications

References 150 publications

Circulating CXCR5+CXCR3+PD-1lo Tfh-like cells in HIV-1 controllers with neutralizing antibody breadth

Circulating CXCR5+CXCR3+PD-1lo Tfh-like cells in HIV-1 controllers with neutralizing antibody breadth

Cancer stem cells - from initiation to elimination, how far have we reached? (Review)

Study on Acupuncture and Moxibustion of the Notch Signaling Pathway in Bone Marrow Cells to Alleviate Cyclophosphamide-Induced Myelosuppression in Mice

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