Not yet standard: retinoids versus second primary tumors.

Lippman, S. M.; Hong, Waun Ki

doi:10.1200/jco.1993.11.7.1204

Cited by 23 publications

(8 citation statements)

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“…Despite various therapeutic interventions, including surgery, radiotherapy, and chemotherapy, the 5-year survival rate for this disease has improved only marginally during the past two decades. For patients with disease confined to the head and neck, there are two major and distinct patterns of treatment failures after definitive therapy: recurrence of primary disease (local, regional or distant) and development of SPC [23,24]. The 5-year survival rate after SPC diagnosis is about 8% if the malignancy is outside the head and neck area, and increased to 30% if the SPC is an HNC [25].…”

Section: Introductionmentioning

confidence: 99%

Clinical features and prognostic factors in patients with head and neck cancer: Results from a multicentric study

Leoncini

Vuković

Cadoni

et al. 2015

Cancer Epidemiology

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Section: Introductionmentioning

confidence: 99%

Clinical features and prognostic factors in patients with head and neck cancer: Results from a multicentric study

Leoncini

Vuković

Cadoni

et al. 2015

Cancer Epidemiology

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“…Head and neck cancer patients who have been successfully treated remain at a significantly increased risk for developing additional neoplasms within the UADT and lungs (63)(64)(65)(66)(67)(68)(69). The concept of multistep field cancerization explains the development of multiple independent tumor sites within the aerodigestive tract.…”

Section: Prevention Of Second Primary Tumorsmentioning

confidence: 99%

Chemoprevention of Aerodigestive Tract Cancers

Kim

Hong²,

Khuri³

2002

Annu. Rev. Med.

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Epithelial cancers are a major worldwide health problem. Since the mid-1970s, advances in multidisciplinary cancer therapeutics have only slightly improved the mortality rate from epithelial malignancies. Chemoprevention is the use of specific natural or synthetic chemical agents to reverse, suppress, or prevent progression to invasive cancer. Chemopreventive medicine is based on translating basic biologic research into clinical chemical interventions, thus attempting to impede carcinogenesis. Its principles build on the concepts of field cancerization (diffuse epithelial injury that results from carcinogen exposure) and multistep carcinogenesis (a stepwise accumulation of cellular and genetic alterations that progress to cancer). Chemoprevention targets the carcinogenic process at earlier and potentially more reversible stages, focusing on the inhibition of one or many steps in the progression towards cancer. Strategies of chemoprevention include primary prevention in groups at high risk, reversal of premalignant lesions, and prevention of second primary tumors.

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“…Patients with cancers of the aerodigestive tract (lung, head, and neck) who have been treated successfully remain at a significantly increased risk for developing additional neoplasms within the same area [20][21][22][23][24][25][26]. The concept of multistep field cancerization explains the development of multiple independent tumor sites within the aerodigestive tract.…”

Section: Second Primary Tumorsmentioning

confidence: 99%

Chemoprevention of lung cancer

Kim

Khuri

2002

Curr Oncol Rep

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Lung cancer is the leading cause of death worldwide. Its overall survival rate has improved only slightly, and surgery, radiotherapy, and chemotherapy remain the mainstays of current treatment. Therapies with novel targeted agents are currently under active investigation in all settings of treatment including chemoprevention, defined as the use of natural or synthetic agents to interrupt the process of carcinogenesis and to prevent or delay tumor occurrence. Thus, chemoprevention describes the collaborative efforts of researchers in basic science and clinical settings who study the biology of lung cancer with the hope of uncovering new mechanisms of treatment. Because lung cancer has become an increasingly difficult problem to treat with standard therapies, chemopreventive strategies have been developed. Small molecule compounds that target specific receptors or mutations will play an increasingly significant role in treatment of lung cancer because the side effect profiles of such agents are tolerable and they may be more effective than other treatments.

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Not yet standard: retinoids versus second primary tumors.

Cited by 23 publications

References 0 publications

Clinical features and prognostic factors in patients with head and neck cancer: Results from a multicentric study

Clinical features and prognostic factors in patients with head and neck cancer: Results from a multicentric study

Chemoprevention of Aerodigestive Tract Cancers

Chemoprevention of lung cancer

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