Not spreading in reverse: The dewetting of a liquid film into a single drop

Edwards, Andrew M.; Ledesma‐Aguilar, Rodrigo; Newton, Michael I.; Brown, C. V.; McHale, Glen

doi:10.1126/sciadv.1600183

Cited by 62 publications

(86 citation statements)

References 40 publications

(45 reference statements)

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“…5a; Supplementary Movie 11). This striking symmetry breaking is in stark contrast with the known isotropic dewetting of passive fluids [45][46][47] . Although pinning of the contact line [46][47][48] may contribute to breaking the radius island that loses its circular symmetry during dewetting, as shown by its contour (red line).…”

Section: Active Forces Govern Tissue Morphology During Dewettingmentioning

confidence: 60%

Active wetting of epithelial tissues

et al. 2018

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Development, regeneration and cancer involve drastic transitions in tissue morphology. In analogy with the behavior of inert fluids, some of these transitions have been interpreted as wetting transitions. The validity and scope of this analogy are unclear, however, because the active cellular forces that drive tissue wetting have been neither measured nor theoretically accounted for. Here we show that the transition between two-dimensional epithelial monolayers and three-dimensional spheroidal aggregates can be understood as an active wetting transition whose physics differs fundamentally from that of passive wetting phenomena. By combining an active polar fluid model with measurements of physical forces as a function of tissue size, contractility, cell-cell and cell-substrate adhesion, and substrate stiffness, we show that the wetting transition results from the competition between traction forces and contractile intercellular stresses. This competition defines a new intrinsic lengthscale that gives rise to a critical size for the wetting transition in tissues, a striking feature that has no counterpart in classical wetting. Finally, we show that active shape fluctuations are dynamically amplified during tissue dewetting. Overall, we conclude that tissue spreading constitutes a prominent example of active wetting — a novel physical scenario that may explain morphological transitions during tissue morphogenesis and tumor progression.

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Section: Active Forces Govern Tissue Morphology During Dewettingmentioning

confidence: 60%

Active wetting of epithelial tissues

et al. 2018

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“…Edwards et al (16) analyzed the dewetting of a liquid film into a single drop. For a large thin liquid film, they identified two dynamic regimes: A first regime where the radius decreases linearly in time, accompanied by an annular rim close to the contact line, and a second regime where the rim merges, and the film relaxes exponentially to a spherical cap shape.…”

Section: Aggregate Formation Dynamics Of Progenitor Cells Are Consistmentioning

confidence: 99%

“…2(a). For this regime, Edwards et al(16) found an analytical expression, relating the exponential relaxation time τ to the viscosity η a , the surface tension γ a and the volume V a of the aggregate, namely…”

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confidence: 99%

Compaction dynamics during progenitor cell self-assembly reveal granular mechanics

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Pešek

Deckers

et al. 2019

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We study the self-assembly dynamics of human progenitor cells in agarose micro-wells that are used for production of chondrogenic organoids. Using image analysis on time-lapse microscopy, we estimate the aggregate area in function of time for a large number of aggregates. In control conditions, the aggregate radius follows an exponential relaxation that is consistent with the dewetting dynamics of a liquid film. Introducing Y-27632 Rho kinase inhibitor, the compatibility with the liquid model is lost, and slowed down relaxation dynamics are observed. We demonstrate that these aggregates behave as granular piles undergoing compaction, with a density relaxation that follows a stretched exponential. Using simulations with an individual cell-based model, we construct a phase diagram of cell aggregates that suggests that the aggregate in presence of Rho kinase inhibitor approaches the glass transition.

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“…This modification is proven valid for different insulating layer thicknesses [86] opening a feasibility to applied dielectrowetting phenomenon into applications such as dynamically controlling droplets spreading [87] and retracting [88] (Fig. 2.21).…”

Section: Fundamentals Of Dielectrowetting and Its Applicationsmentioning

confidence: 90%

“…(H) Schematic of the dynamic contact angle versus time of the dewetting droplet. All the figures here are reproduced from the work of Edwards et al[88]…”

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confidence: 99%

Contact line dynamics of droplets under electrowetting actuation

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Not spreading in reverse: The dewetting of a liquid film into a single drop

Abstract: Dewetting films are not the time reversal of spreading droplets.

Cited by 62 publications

References 40 publications

Active wetting of epithelial tissues

Active wetting of epithelial tissues

Compaction dynamics during progenitor cell self-assembly reveal granular mechanics

Contact line dynamics of droplets under electrowetting actuation

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