Not only metformin, but also D-allulose, alleviates metabolic disturbance and cognitive decline in prediabetic rats

Pratchayasakul, Wasana; Jinawong, Kewarin; Pongkan, Wanpitak; Jaiwongkam, Thidarat; Arunsak, Busarin; Chunchai, Titikorn; Tokuda, Masaaki; Chattipakorn, Nipon

doi:10.1080/1028415x.2020.1840050

Cited by 17 publications

(19 citation statements)

References 40 publications

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“…Notably, the HE-clamp showed similar insulin sensitivity between the HFA and standard CD groups, despite the presence of higher visceral fat in the HFA group than in the CD group. Our results are consistent with those of others demonstrating that D-allulose in drinking water improves insulin sensitivity without affecting body weight or fat mass [15,16], indicating its mechanism is independent of weight loss or fat reduction. In the two-step HE-clamp test, low-dose insulin infusion GIR refers to insulin sensitivity of the liver and peripheral tissues [17], whereas high-dose insulin infusion GIR refers to the insulin sensitivity index of the skeletal muscle [18].…”

Section: Discussionsupporting

confidence: 93%

d-Allulose Ameliorates Skeletal Muscle Insulin Resistance in High-Fat Diet-Fed Rats

et al. 2021

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Background: d-Allulose is a rare sugar with antiobesity and antidiabetic activities. However, its direct effect on insulin sensitivity and the underlying mechanism involved are unknown. Objective: This study aimed to investigate the effect of d-allulose on high-fat diet (HFD)-induced insulin resistance using the hyperinsulinemic–euglycemic (HE)-clamp method and intramuscular signaling analysis. Methods: Wistar rats were randomly divided into three dietary groups: chow diet, HFD with 5% cellulose (HFC), and HFD with 5% d-allulose (HFA). After four weeks of feeding, the insulin tolerance test (ITT), intraperitoneal glucose tolerance test (IPGTT), and HE-clamp study were performed. The levels of plasma leptin, adiponectin, and tumor necrosis factor (TNF)-α were measured using the enzyme-linked immunosorbent assay. We analyzed the levels of cell signaling pathway components in the skeletal muscle using Western blotting. Results: d-allulose alleviated the increase in HFD-induced body weight and visceral fat and reduced the area under the curve as per ITT and IPGTT. d-Allulose increased the glucose infusion rate in the two-step HE-clamp test. Consistently, the insulin-induced phosphorylation of serine 307 in the insulin receptor substrate-1 and Akt and expression of glucose transporter 4 (Glut-4) in the muscle were higher in the HFA group than HFC group. Furthermore, d-allulose decreased plasma TNF-α concentration and insulin-induced phosphorylation of stress-activated protein kinase/Jun N-terminal kinase in the muscle and inhibited adiponectin secretion in HFD-fed rats. Conclusions: d-allulose improved HFD-induced insulin resistance in Wistar rats. The reduction of the proinflammatory cytokine production, amelioration of adiponectin secretion, and increase in insulin signaling and Glut-4 expression in the muscle contributed to this effect.

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Section: Discussionsupporting

confidence: 93%

d-Allulose Ameliorates Skeletal Muscle Insulin Resistance in High-Fat Diet-Fed Rats

et al. 2021

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“…Furthermore, Ochiai et al showed that D-allulose increases resting energy expenditure in HSD-fed rats and contributes to reducing body weight [8]. Notably, recent reports using drinking water containing D-allulose showed improvement in insulin sensitivity in rats fed with a high-fat diet without affecting their body weights or fat masses, indicating that the mechanisms involved are independent of body weight or fat reduction [37,38].…”

Section: Discussionmentioning

confidence: 99%

Investigation of d-allulose effects on high-sucrose diet-induced insulin resistance via hyperinsulinemic-euglycemic clamps in rats

Natsume

Yamada

Iida

et al. 2021

Heliyon

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d -Allulose, a C-3 epimer of d -fructose, is a rare sugar that has no calories. Although d- allulose has been reported to have several health benefits, such as anti-obesity and anti-diabetic effects, there have been no reports evaluating the effects of d- allulose on insulin resistance using a hyperinsulinemic-euglycemic clamp (HE-clamp). Therefore, we investigated the effects of d- allulose on a high-sucrose diet (HSD)-induced insulin resistance model. Wistar rats were randomly divided into three dietary groups: HSD containing 5% cellulose (HSC), 5% d- allulose (HSA), and a commercial diet. The insulin tolerance test (ITT) and HE-clamp were performed after administration of the diets for 4 and 7 weeks. After 7 weeks, the muscle and adipose tissues of rats were obtained to analyze Akt signaling via western blotting, and plasma adipocytokine levels were measured. ITT revealed that d- allulose ameliorated systemic insulin resistance. Furthermore, the results of the 2-step HE-clamp procedure indicated that d- allulose reversed systemic and muscular insulin resistance. d- Allulose reversed the insulin-induced suppression of Akt phosphorylation in the soleus muscle and epididymal fat tissues and reduced plasma TNF-α levels. This study is the first to show that d- allulose improves systemic and muscle insulin sensitivity in conscious rats.

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“…In addition to the beneficial effects of D-allulose on metabolic control, D-allulose can improve brain function and cognition in prediabetic rats by alleviating brain oxidative stress, brain mitochondrial ROS production, hippocampal apoptosis, brain insulin insensitivity, and hippocampal synaptic dysfunction (Pratchayasakul et al, 2020).…”

Section: Physiological Functionsmentioning

confidence: 99%

Bioproduction of D‐allulose: Properties, applications, purification, and future perspectives

Jiang

et al. 2021

Comp Rev Food Sci Food Safe

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D-allulose is the C-3 epimer of D-fructose, which rarely exists in nature, and can be biosynthesized from D-fructose by the catalysis of D-psicose 3-epimerase. Dallulose is safe for human consumption and was recently approved by the United States Food and Drug Administration for food applications. It is not only able be used in food and dietary supplements as a low-calorie sweetener, but also modulates a variety of physiological functions. D-allulose has gained increasing attention owing to its excellent properties. This article presents a review of recent progress on the properties, applications, and bioproduction progress of D-allulose.

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Not only metformin, but also D-allulose, alleviates metabolic disturbance and cognitive decline in prediabetic rats

Cited by 17 publications

References 40 publications

d-Allulose Ameliorates Skeletal Muscle Insulin Resistance in High-Fat Diet-Fed Rats

d-Allulose Ameliorates Skeletal Muscle Insulin Resistance in High-Fat Diet-Fed Rats

Investigation of d-allulose effects on high-sucrose diet-induced insulin resistance via hyperinsulinemic-euglycemic clamps in rats

Bioproduction of D‐allulose: Properties, applications, purification, and future perspectives

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