Not every pigmented tumour is melanoma: Adenoma of the ciliary body pigment epithelium

Melanin-Targeted PET Imaging Sheds Light on Pigment Epithelioma in Corpus Ciliare

“…Pathology ( A ) showed monomorphic tumor cells and scattered melanin granules ( B , yellow arrows) in the cytoplasm of some cells, which were identified as pigmented epithelial adenoma 2,3 . Although active melanin production occurs mainly in melanoma, 4 pigment epithelioma and other tumors can also express melanin 5 . Pigment epithelioma in corpus ciliare is rare, 5,6 and it is difficult to be diagnosed in clinic 7,8 .…”

“…2,3 Although active melanin production occurs mainly in melanoma, 4 pigment epithelioma and other tumors can also express melanin. 5 Pigment epithelioma in corpus ciliare is rare, 5,6 and it is difficult to be diagnosed in clinic. 7,8 The melanin-targeted probe, 18 F-PFPN, with a high affinity to melanin, 9 could clearly detect the lesion missed by 18 F-FDG PET images.…”