Not boring at all

Hunter, Philip

doi:10.1038/embor.2009.2

Cited by 52 publications

(35 citation statements)

References 2 publications

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“…The medical use of BCCs is no longer limited to a few compounds such as boric acid, bortezomib and boromycin (Nielsen, 1991;Groziak, 2001;Das, 2013;Soriano-Ursúa, 2014a), and the scope of therapeutic applications is not restricted to antiseptics, antibiotics or anticancer agents. From an academic perspective, the reactivity of boron and its similarity to nitrogen, carbon and oxygen is a fascinating research topic (Hunter, 2009). The work of those considered "the icons of boron chemistry" is much more well-known today than previously (special mention is made of the Nobel Prize in 1979 given to Hebert C. Brown) (Hosmane, 2012).…”

Section: Recognizing and Widening Bcc Applications In Medicinal Chemimentioning

confidence: 99%

“…Unlike mercury salts, BCCs have only been used for a little over a century to produce a beneficial effect for humans, being employed as antiseptics, antibiotics, cosmetics and insecticides (Kingma, 1958;Hunter, 2009;Groziak, 2001). In the last few decades, their use has been extended to new antibiotics and anticancer drugs (Das, 2013;Del Rosso, 2014).…”

Section: Introductionmentioning

confidence: 97%

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Current data regarding the structure-toxicity relationship of boron-containing compounds

et al. 2016

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Section: Recognizing and Widening Bcc Applications In Medicinal Chemimentioning

confidence: 99%

Section: Introductionmentioning

confidence: 97%

Current data regarding the structure-toxicity relationship of boron-containing compounds

et al. 2016

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“…4−6 Boron differs from carbon in that it has a vacant p-orbital that is receptive to dative bond formation with oxygen nucleophiles. Nucleophilic addition transforms boron from neutral trigonal planar to anionic tetraheadral.…”

Section: Introductionmentioning

confidence: 99%

Repurposing Suzuki Coupling Reagents as a Directed Fragment Library Targeting Serine Hydrolases and Related Enzymes

et al. 2017

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Serine hydrolases are susceptible to potent reversible inhibition by boronic acids. Large collections of chemically diverse boronic acid fragments are commercially available because of their utility in coupling chemistry. We repurposed the approximately 650 boronic acid reagents in our collection as a directed fragment library targeting serine hydrolases and related enzymes. Highly efficient hits (LE > 0.6) often result. The utility of the approach is illustrated with the results against autotaxin, a phospholipase implicated in cardiovascular disease.

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“…Boron (B) is a trivalent metalloid, an essential plant nutrient and a component of boromycin-an antibiotic compound produced by Streptomyces. This element has been used for drug design 29 and boron neutron capture therapy (BNCT) for cancers, such as glioblastoma multiforme. 30 Glioblastoma multiforme is the most common and aggressive type of primary brain tumors in humans.…”

Section: Bioimaging Of Metals At the Single-cell Levelmentioning

confidence: 99%

Trace metal imaging with high spatial resolution: Applications in biomedicine

et al. 2011

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New generations of analytical techniques for imaging of metals are pushing hitherto boundaries of spatial resolution and quantitative analysis in biology. Because of this, the application of these imaging techniques described herein to the study of the organization and dynamics of metal cations and metal-containing biomolecules in biological cell and tissue is becoming an important issue in biomedical research. In the current review, three common metal imaging techniques in biomedical research are introduced, including synchrotron X-ray fluorescence (SXRF) microscopy, secondary ion mass spectrometry (SIMS), and laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS). These are exemplified by a demonstration of the dopamine-Fe complexes, by assessment of boron distribution in a boron neutron capture therapy cell model, by mapping Cu and Zn in human brain cancer and a rat brain tumor model, and by the analysis Metallomics, 2011, 3, 28-37 29 of metal topography within neuromelanin. These studies have provided solid evidence that demonstrates that the sensitivity, spatial resolution, specificity, and quantification ability of metal imaging techniques is suitable and highly desirable for biomedical research. Moreover, these novel studies on the nanometre scale (e.g., of individual single cells or cell organelles) will lead to a better understanding of metal processes in cells and tissues.

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Not boring at all

Cited by 52 publications

References 2 publications

Current data regarding the structure-toxicity relationship of boron-containing compounds

Current data regarding the structure-toxicity relationship of boron-containing compounds

Repurposing Suzuki Coupling Reagents as a Directed Fragment Library Targeting Serine Hydrolases and Related Enzymes

Trace metal imaging with high spatial resolution: Applications in biomedicine

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