Not at random location of atherosclerotic lesions in thoracic aorta and their prognostic significance in relation to the risk of cardiovascular events

Abstract

SummaryThoracic aortic calcium deposits are frequently detected on tomography of the chest, and in other imaging modalities. Numerous studies indicated the correlation of hemodynamic parameters such as wall shear stress in relation to distribution aortic calcifications. This publication discusses similarities and differences of two distinct pathomechanisms of arterial calcifications: intimal associated with atherosclerosis and medial knows as Mönckeberg’s arteriosclerosis. This review also analyzes the frequent coexistence of aortic calcification and coronary artery disease in terms of risk of cardiovascular events.

Transradial versus transfemoral access for acute stroke endovascular thrombectomy: a 4-year experience in a high-volume center

“…TRA may be the first option when TFA-related difficulties or complications may be expected (e.g., obesity and deep femoral vessels, high hemorrhagic risk, and severe aortoiliac/femoral disease). In atherosclerosis the aortic arch, TRA may be also a safer option because calcifications are more often encountered in the aortic arch and the descending aorta rather than the ascending aorta [29,30].…”

RANKL Inhibits the Production of Osteoprotegerin from Smooth Muscle Cells under Basal Conditions and following Exposure to Cyclic Strain

“…The natural corollary to this, however, is that once VC becomes established within a vessel wall, the compliance and flexibility of the vessel will be reduced, and gradually its responsiveness to cyclic strain. This may contribute to an injurious cycle of increasing calcification, decreasing strain, decreasing OPG production, and further increased calcification, a hypothesis supported in part by the observation that abnormal areas of hemodynamic stress often colocate with atherosclerosis and VC within the vascular tree in vivo [26].…”

The Fluid Dynamical Performance of the Carpentier-Edwards PERIMOUNT Magna Ease Prosthesis

“…Higher velocities or vortices in combination with higher values for strain and increased velocity gradients represent a higher biomechanical load on the aortic tissue and are assumed to have a strong impact on pathological processes [ 19 ]. Therefore, a relation between hemodynamics and atherosclerotic lesions was observed [ 20 ].…”