Nosocomial urinary tract infection in critical pediatric patients

Flores-González, J.C.; Hernández-Gonzalez, Arturo; Rodríguez-López, Claudia; Roldan-Cano, Virginia; Rubio-Quiñones, Fernando; Quintero-Otero, S.; García-Palacios, María; Pantoja-Rosso, S.

doi:10.1016/j.medine.2011.02.004

Cited by 4 publications

(3 citation statements)

References 21 publications

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“…An indwelling urinary catheter is one part of the management for frequent and accurate monitoring of urinary output in comatose patients. Catheter-associated urinary tract infection (CAUTI) remains the second most common healthcare-associated infection in critically patients, accounting for 60% to 80% of urinary tract infections (UTIs) [ 1 , 2 ]. Comatose patients are at 2–5 times greater risk of CAUTI due to immobility and incomplete bladder emptying [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Efficacy of expanded periurethral cleansing in reducing catheter-associated urinary tract infection in comatose patients: a randomized controlled clinical trial

Qin,

Zhao,

Qin

et al. 2024

Crit Care

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Background The effect of the periurethral cleansing range on catheter-associated urinary tract infection (CAUTI) occurrence remains unknown. The purpose of this study was to evaluate the efficacy of expanded periurethral cleansing for reducing CAUTI in comatose patients. Methods In this randomized controlled trial, eligible patients in our hospital were enrolled and allocated randomly to the experimental group (expanded periurethral cleansing protocol; n = 225) or the control group (usual periurethral cleansing protocol; n = 221). The incidence of CAUTI on days 3, 7, and 10 after catheter insertion were compared, and the pathogen results and influencing factors were analyzed. Results The incidences of CAUTI in the experimental and control groups on days 3, 7, and 10 were (5/225, 2.22% vs. 7/221, 3.17%, P = 0.54), (12/225, 5.33% vs. 18/221, 8.14%, P = 0.24), and (23/225, 10.22% vs. 47/221, 21.27%, P = 0.001), respectively; Escherichia coli and Candida albicans were the most common species in the two groups. The incidences of bacterial CAUTI and fungal CAUTI in the two groups were 11/225, 4.89% vs. 24/221, 10.86%, P = 0.02) and (10/225, 4.44% vs. 14/221, 6.33%, P = 0.38), respectively. The incidences of polymicrobial CAUTI in the two groups were 2/225 (0.89%) and 9/221 (4.07%), respectively (P = 0.03). The percentages of CAUTI-positive females in the two groups were 9.85% (13/132) and 29.52% (31/105), respectively (P < 0.05). The proportion of CAUTI-positive patients with diabetes in the experimental and control groups was 17.72% (14/79), which was lower than the 40.85% (29/71) in the control group (P < 0.05). Conclusion Expanded periurethral cleansing could reduce the incidence of CAUTI, especially those caused by bacteria and multiple pathogens, in comatose patients with short-term catheterization (≤ 10 days). Female patients and patients with diabetes benefit more from the expanded periurethral cleansing protocol for reducing CAUTI.

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Section: Introductionmentioning

confidence: 99%

Efficacy of expanded periurethral cleansing in reducing catheter-associated urinary tract infection in comatose patients: a randomized controlled clinical trial

Qin,

Zhao,

Qin

et al. 2024

Crit Care

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“…Hospitalacquired infections (HAIs) or nosocomial infections are a source of diseases that may pose a threat to public health. The occurrence of infection to patients within 48-h of hospital stay or a month after any invasive procedure is known as nosocomial infections [3]. ESBL producing Enterobacteriaceae, especially Klebsiella pneumoniae and Escherichia coli are recognized globally as major causes of nosocomial and community-acquired infections [4].…”

Section: Introductionmentioning

confidence: 99%

Emergence of extended spectrum beta-lactamases-producing strains belonging to cefotaxime-M-1 class from intensive care units patients and environmental surfaces in Pakistan

Bukhari¹,

Arshad²,

Raza³

et al. 2016

Int J One Health

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Aim:The emergence of multidrug-resistant (MDR) bacteria is the most dangerous threat for the treatment of infectious diseases. The aim of this study was to detect and characterize extended spectrum beta-lactamases (ESBLs) and carbapenemaseproducing Klebsiella pneumoniae and Escherichia coli among patients and environment of intensive care units (ICUs) of three tertiary care hospitals in Pakistan. Materials and Methods:A total of 82 samples from ICU's patients and inanimate environment (injection trays, wash basins, door handles, hand swabs of professionals, and ICU fridges) were screened for ESBL by culturing on CHROMagar-ESBL. ESBL and carbapenemases production were confirmed by double disc synergy test and modified Hodge's test, respectively. Polymerase chain reaction was used to detect ESBL encoding genes bla cefotaxime (CTX-M), blaCTX-M-1, blaCTX-M-2, blaCTX-M-9, blaTEM, blaSHV and carbapenemase genes blaKPC, bla New Delhi metallo-beta-lactamase-1, blaOXA-48 and blaVIM.Results: Overall, ESBL production was found high 30/82 (36.5%) among isolates of which 15.8% K. pneumoniae and 20.7% E. coli were identified. All the K. pneumoniae and majority of E. coli isolates were MDR, i.e., resistance to three or more antimicrobial categories. Molecular characterization showed the blaCTX-M-1 as the predominant genotype found in 17/21 (80%) of the isolates. None of the strains was found positive for carbapenemase-encoding genes. Conclusion:In conclusion, this study demonstrates the emergence of MDR ESBL producing strains among ICU patients and hospital environment, posing a serious threat for the control of nosocomial infections.

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“…[1][2][3] Penggunaan kateter urin pada pasien anak, terutama di rumah sakit dan ruang intensif (PICU), sering diperlukan untuk pemantauan cairan. 1,4 Namun, pemakaian kateter urin tidak sepenuhnya aman, dengan catheter-associated urinary tract infection (CAUTI) sebagai efek samping yang sering terjadi, mencapai sekitar 80% ISK di rumah sakit. [6][7][8][9][10] Penelitian sebelumnya di Amerika dan Turki menunjukkan bahwa CAUTI pada anak memiliki angka kejadian dan morbiditas yang tinggi, menduduki peringkat ketiga healthcare-associated infections (HAIs), setelah pneumonia dan infeksi luka operasi.…”

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Prevalensi dan Faktor Risiko Catheter Associated Urinary Tract Infection di Unit Perawatan Intensif Anak

Febrianti,

Alam,

Rachmadi

2023

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Latar belakang. Sekitar 80% Infeksi Saluran Kemih yang didapat di rumah sakit yang berhubungan dengan penggunaan kateter urin atau catheter-associated urinary tract infection. Beberapa faktor risiko dianggap memengaruhi kejadian CAUTI. Hingga saat ini, prevalensi CAUTI pasien anak di Rumah Sakit Dr. Hasan Sadikin belum tercatat dan pola kuman penyebab CAUTI serta sensitivitas antibiotik dapat bervariasi antar rumah sakit.Tujuan. Mengetahui prevalensi catheter-associated urinary tract infection di Unit Perawatan Intensif Anak Rumah Sakit Hasan Sadikin dan menganalisis faktor risiko yang menyebabkannya.Metode. Penelitian ini merupakan studi observasional analitik dengan metode kasus-kontrol menggunakan data sekunder dari rekam medis pasien yang terpasang kateter urin, dirawat di Unit Perawatan Intensif Anak Rumah Sakit Umum Pusat Dr. Hasan Sadikin tahun 2017-2019, baik terdiagnosis CAUTI maupun tidak terdiagnosis CAUTI.Hasil. Sebanyak 138 subjek memenuhi kriteria inklusi penelitian, kemudian dikelompokkan masing-masing 69 pasien kriteria kasus dan kontrol. Sebagian besar subjek berjenis kelamin laki-laki. Usia terbanyak adalah 11-18 tahun (33,3%) pada kelompok kasus dengan status gizi normal (50,7%). Dari enam faktor risiko yang diteliti hanya satu yang menunjukkan perbedaan bermakna yaitu diagnosis awal saat dirawat (sepsis). Kesimpulan. Prevalensi CAUTI cukup tinggi. terutama terkait dengan diagnosis awal sepsis. Penelitian lanjutan perlu dilakukan dan pemeriksaan rutin kultur urin dianjurkan untuk diagnosis dan terapi yang efektif.

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Nosocomial urinary tract infection in critical pediatric patients

Cited by 4 publications

References 21 publications

Efficacy of expanded periurethral cleansing in reducing catheter-associated urinary tract infection in comatose patients: a randomized controlled clinical trial

Efficacy of expanded periurethral cleansing in reducing catheter-associated urinary tract infection in comatose patients: a randomized controlled clinical trial

Emergence of extended spectrum beta-lactamases-producing strains belonging to cefotaxime-M-1 class from intensive care units patients and environmental surfaces in Pakistan

Prevalensi dan Faktor Risiko Catheter Associated Urinary Tract Infection di Unit Perawatan Intensif Anak

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