Nosocomial Streptococcus pneumoniae infection causing children's acute otitis media

Marton, A; Nagy, A; Katona, Gábor; Fekete, Ferenc; Votisky, Peter; Lajos, Z.

doi:10.1016/s0924-8579(96)00357-3

Cited by 4 publications

(4 citation statements)

References 16 publications

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“…The infections due to S. pneumoniae include otitis media (6, 7), sinusitis, peritonitis, and rare cases of endocarditis (8). S. pneumoniae colonizes the upper respiratory tract, especially in children, with an estimate of one infection for every child up to the age of 6 years in the United States (1, 9, 10). The most closely related species on the basis of 16S rRNA sequences are Streptococcus oralis and Streptococcus mitis , which share over 99% sequence identity with S. pneumoniae , although genomic similarities for the entire chromosome are estimated to be <60% (11–13).…”

Section: Genome Announcementmentioning

confidence: 99%

Draft Genome Sequence of an Atypical Strain of Streptococcus pneumoniae Isolated from a Respiratory Infection

et al. 2014

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Next-generation sequencing was used to investigate an unknown clinical respiratory infection. This new strain of Streptococcus pneumoniae, ASVL_JC_0001, was isolated from a clinical specimen from a patient with bronchitis and pulmonary inflammation. The draft genome sequence, obtained with an Illumina MiSeq sequencing system, consists of 83 large contigs, a total of 2,092,532 bp long, and has a GC content of 40.3%.

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Section: Genome Announcementmentioning

confidence: 99%

Draft Genome Sequence of an Atypical Strain of Streptococcus pneumoniae Isolated from a Respiratory Infection

et al. 2014

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“…Thirteen reports were published from 1916 to 1946, and the remainder were published after 1980. Unique outbreaks by disease syndrome were as follows; 80 lower respiratory tract infection [ 12 – 97 ], 9 conjunctivitis [ 98 – 105 ], 3 otitis media [ 106 , 107 ], 1 surgical site infection [ 108 ], and 1 lower respiratory tract infection and otitis media [ 109 ] (Fig. 1 ).…”

Section: Resultsmentioning

confidence: 99%

“…This study was unable to directly link the two manifestations of pneumococcal disease. Two outbreaks occurred in hospitals in Hungary during 1993–1994 and 1996 [ 106 ]. No carriers were reported among healthcare personnel and transmission was believed to occur between patients in the hospital since case-patients shared rooms.…”

Section: Resultsmentioning

confidence: 99%

Streptococcus pneumoniae outbreaks and implications for transmission and control: a systematic review

et al. 2018

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BackgroundStreptococcus pneumoniae is capable of causing multiple infectious syndromes and occasionally causes outbreaks. The objective of this review is to update prior outbreak reviews, identify control measures, and comment on transmission.MethodsWe conducted a review of published S. pneumoniae outbreaks, defined as at least two linked cases of S. pneumoniae.ResultsA total of 98 articles (86 respiratory; 8 conjunctivitis; 2 otitis media; 1 surgical site; 1 multiple), detailing 94 unique outbreaks occurring between 1916 to 2017 were identified. Reported serotypes included 1, 2, 3, 4, 5, 7F, 8, 12F, 14, 20, and 23F, and serogroups 6, 9, 15, 19, 22. The median attack rate for pneumococcal outbreaks was 7.0% (Interquartile range: 2.4%, 13%). The median case-fatality ratio was 12.9% (interquartile range: 0%, 29.2%). Age groups most affected by outbreaks were older adults (60.3%) and young adults (34.2%). Outbreaks occurred in crowded settings, such as universities/schools/daycares, military barracks, hospital wards, and long-term care facilities. Of outbreaks that assessed vaccination coverage, low initial vaccination or revaccination coverage was common. Most (73.1%) of reported outbreaks reported non-susceptibility to at least one antibiotic, with non-susceptibility to penicillin (56.0%) and erythromycin (52.6%) being common. Evidence suggests transmission in outbreaks can occur through multiple modes, including carriers, infected individuals, or medical devices. Several cases developed disease shortly after exposure (< 72 h). Respiratory outbreaks used infection prevention (55.6%), prophylactic vaccination (63.5%), and prophylactic antibiotics (50.5%) to prevent future cases. PPSV23 covered all reported outbreak serotypes. PCV13 covered 10 of 16 serotypes. For conjunctival outbreaks, only infection prevention strategies were used.ConclusionsTo prevent the initial occurrence of respiratory outbreaks, vaccination and revaccination is likely the best preventive measure. Once an outbreak occurs, vaccination and infection-prevention strategies should be utilized. Antibiotic prophylaxis may be considered for high-risk exposed individuals, but development of antibiotic resistance during outbreaks has been reported. The short period between initial exposure and development of disease indicates that pneumococcal colonization is not a prerequisite for pneumococcal respiratory infection.Electronic supplementary materialThe online version of this article (10.1186/s41479-018-0055-4) contains supplementary material, which is available to authorized users.

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“…Nosocomial transmission of S. pneumoniae in the pediatric setting has not been as evident. Marton et al 14 proposed that nosocomial transmission of S. pneumoniae occurred among 6 patients in a pediatric hospital, but bacterial isolates were not serotyped or typed by an alternate method. A previous study from South Africa 15 demonstrated a high frequency of penicillin-resistant pneumococci among both inpatients and outpatients, but evidence of nosocomial transmission was not provided, even though resistant pneumococci belonged exclusively to serotypes 6 and 19.…”

Section: Discussionmentioning

confidence: 99%

Nosocomial transmission of penicillin-resistantStreptococcus pneumoniae

1999

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Nosocomial Streptococcus pneumoniae infection causing children's acute otitis media

Cited by 4 publications

References 16 publications

Draft Genome Sequence of an Atypical Strain of Streptococcus pneumoniae Isolated from a Respiratory Infection

Draft Genome Sequence of an Atypical Strain of Streptococcus pneumoniae Isolated from a Respiratory Infection

Streptococcus pneumoniae outbreaks and implications for transmission and control: a systematic review

Nosocomial transmission of penicillin-resistantStreptococcus pneumoniae

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