Nosocomial Outbreaks Caused by<i>Leuconostoc mesenteroides</i>subsp.<i>mesenteroides</i>

Bou, Germán; Saleta, Jesús Luis; Nieto, Juan Antonio; Tomás, Mar; Valdezate, Sylvia; Sousa, Dolores; Lueiro, Francisco; Villanueva, Rosa; Pereira, Maria Jose; Llinares, Pedro

doi:10.3201/eid1406.070581

Cited by 35 publications

(32 citation statements)

References 15 publications

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“…Another advantage of using a DNAbased microarray approach may be to limit one's exposure to Leuconostoc spp. Leuconostoc spp., including L. mesenteroides and L. pseudomesenteroides, are emerging as human pathogens that can lead to severe infections, particularly in immunocompromised individuals (Albanese et al 2006;Bou et al 2008;Deng et al 2012;Kumudhan and Mars 2004;Shin et al 2011;Taneja et al 2005;Tas ‚kapilioglu et al 2011;Tholpady et al 2010;Wong et al 2012;Yang et al 2015). However, considering the rarity of Leuconostoc infections in people and the large presence of Leuconostoc spp.…”

Section: Discussionmentioning

confidence: 99%

Leuconostoc spp. Associated with Root Rot in Sugar Beet and Their Interaction with Rhizoctonia solani

Strausbaugh

2016

Phytopathology®

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Rhizoctonia root and crown rot is an important disease problem in sugar beet caused by Rhizoctonia solani and also shown to be associated with Leuconostoc spp. Initial Leuconostoc studies were conducted with only a few isolates and the relationship of Leuconostoc with R. solani is poorly understood; therefore, a more thorough investigation was conducted. In total, 203 Leuconostoc isolates were collected from recently harvested sugar beet roots in southern Idaho and southeastern Oregon during 2010 and 2012: 88 and 85% Leuconostoc mesenteroides, 6 and 15% L. pseudomesenteroides, 2 and 0% L. kimchi, and 4 and 0% unrecognized Leuconostoc spp., respectively. Based on 16S ribosomal RNA sequencing, haplotype 11 (L. mesenteroides isolates) comprised 68 to 70% of the isolates in both years. In pathogenicity field studies with commercial sugar beet 'B-7', all Leuconostoc isolates caused more rot (P < 0.0001; a = 0.05) when combined with R. solani than when inoculated alone in both years. Also, 46 of the 52 combination treatments over the 2 years had significantly more rot (P < 0.0001; a = 0.05) than the fungal check. The data support the conclusion that a synergistic interaction leads to more rot when both Leuconostoc spp. and R. solani are present in sugar beet roots.

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Section: Discussionmentioning

confidence: 99%

Leuconostoc spp. Associated with Root Rot in Sugar Beet and Their Interaction with Rhizoctonia solani

Strausbaugh

2016

Phytopathology®

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“…With the increasing use of vancomycin in clinical practice, some new vancomycin-resistant pathogenic bacteria are likely to appear. Compromised immunity (Montejo et al, 2000;Espinoza et al, 1997;Ferrer et al, 1995), use of vancomycin, parenteral nutrition (Bou et al, 2008) and contaminated surgical implanted devices, such as central venous catheters (Bou et al, 2008), have been considered as risk factors for Leuconostoc spp. infection, although Leuconostoc infections have also been documented in otherwise healthy patients.…”

Section: Discussionmentioning

confidence: 99%

“…Infection may have been associated with central venous catheterization or as a consequence of parenteral nutrition. VRE isolated from the ascites may have been associated with intestinal colonization (Bou et al, 2008). As the permeability of the gastric cell wall was changed and damage to the skin membrane barrier occurred, colonization of the abdominal cavity was possible.…”

Section: Discussionmentioning

confidence: 99%

A mixed infection of Leuconostoc lactis and vancomycin-resistant Enterococcus in a liver transplant recipient

Deng

Zhang

Xie

et al. 2012

Journal of Medical Microbiology

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Bacterial infection in patients who have undergone liver transplantation is a major complication of the procedure. Leuconostoc spp. are important pathogenic bacteria in individuals with poor immune function, especially transplant patients. In this report, we describe the case of a 45-yearold Asian male liver transplant recipient who was initially preliminarily diagnosed with infection with Leuconostoc pseudomesenteroides by using the microbial tests of the VITEK 2 system and the aesculin hydrolysis test, and with vancomycin-resistant Enterococcus. Subsequently, the Leuconostoc isolate was identified as Leuconostoc lactis by 16S rRNA gene partial sequencing. In this paper, we discuss our identification of L. lactis based on physiological characteristics and molecular methodology. Accurate identification of these infections is important for the outcome; use of 16S rRNA gene sequence analysis offers a rapid and precise diagnostic approach. Administration of the drug linezolid may be useful for the treatment of both Leuconostoc spp. and vancomycin-resistant Enterococcus infections. We suggest that clinical analysts should use molecular methods in addition to biochemical tests in order to identify Leuconostoc at the species level more accurately. IntroductionBacterial infection is a major complication after liver transplantation and the incidence is around 48 %. Vancomycin prophylaxis against Gram-positive bacteraemia following transplantation may prevent infection. However, with the increasing use of vancomycin in clinical practice, new vancomycin-resistant pathogenic bacteria are likely to appear.Leuconostoc spp. are Gram-positive, catalase-negative bacteria and are intrinsically resistant to vancomycin (Facklam & Elliott, 1995;Bernaldo de Quiró s et al., 1991). As a consequence of their irregular coccoid morphology, they used to be listed as members of the Streptococcaceae, but are now recognized as Leuconostocaceae and are placed within the order Lactobacillales. These bacteria are found in the environment, e.g. on vegetables and in dairy and other fermented products, but are known to occasionally cause infection in humans. Subsequent to 1985, several infections that resulted from Leuconostoc spp., namely Leuconostoc mesenteroides and Leuconostoc pseudomesenteroides, have been reported (Handwerger et al., 1990;Bernaldo de Quiró s et al., 1991;Dhodapkar & Henry, 1996). Most reported cases were bloodstream infections; however, these bacteria are also a cause of meningitis, pneumonia, endocarditis, pleural empyema, osteomyelitis or urinary tract infections. However, to date, no deaths related to Leuconostoc spp. infection have been reported (Facklam & Elliott, 1995;Bernaldo de Quiró s et al., 1991;Montejo et al., 2000;Espinoza et al., 1997;Giraud et al., 1993;Yamazaki et al., 2009). Some Enterococcus spp. are commensal organisms in the intestine. Furthermore, vancomycin-resistant enterococci (VRE) are recognized as some of the most significant nosocomial pathogens in the world because of their rapid spread, high mor...

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“…3 De forma más reciente, se lo ha implicado incluso en la produción de epidemias en algunas instituciones. 8 Afortunadamente, la virulencia de estas infecciones no es muy elevada e, incluso, en algunos casos de aislamiento polimicrobiano se duda de su patogenicidad.…”

Section: Comentariounclassified

“…Lo que sí parece demostrado es que algunas formas asociadas a nutrición enteral y parenteral son secundarias a la contaminación de éstas por defectos en la elaboración. 8,11 Leucoe34 / Arch Argent Pediatr 2012;110(2):e32-e34 / Presentación de casos clínicos nostoc se puede encontrar de manera habitual en la piel, por lo que la presencia de catéteres venosos o peritoneales que eliminan la barrera cutánea permiten su entrada al organismo, y también en la vagina, lo cual favorece la colonización de los recién nacidos de madres portadoras durante el parto. 12 Otra posibilidad de contagio descrita es la contaminación de la leche, sobre todo si es preparada a partir de polvo y se administra por sonda gástrica.…”

Section: Comentariounclassified

Sepsis por Leuconostoc spp. en un lactante sano

Martínez-Pajares¹,

Díaz-Morales²,

Acosta-González³

et al. 2012

Arch Argent Pediat

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Presentación de casos clínicos RESUMENEl género Leuconostoc, del grupo de bacterias ácido-lácticas, son cocos grampositivos resistentes a vancomicina, distribuidos en la naturaleza y empleados en la industria alimentaria. Clásicamente considerado inocuo para la especie humana, se lo ha implicado en diversas patologías en sujetos susceptibles; se lo aisló cada vez con más frecuencia y con un amplio perfil de patogenicidad, por lo que en la actualidad se clasifica como patógeno oportunista emergente. Los niños son especialmente vulnerables, sobre todo prematuros y afectos de patología digestiva grave. La puerta de entrada no ha sido estudiada en profundidad; las más probables son la digestiva, en intestinos alterados, y la cutánea, a través de la pérdida de su integridad. Otras formas descritas son contaminaciones de la nutrición parenteral y enteral, esta última asociada sobre todo al uso de sondas gástricas. Los aislados casos descritos en pacientes inmunocompetentes sin factores de riesgo involucran, sobre todo, a lactantes sanos, como el caso que presentamos. Palabras clave: Leuconostoc, sepsis.

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Nosocomial Outbreaks Caused byLeuconostoc mesenteroidessubsp.mesenteroides

Cited by 35 publications

References 15 publications

Leuconostoc spp. Associated with Root Rot in Sugar Beet and Their Interaction with Rhizoctonia solani

Leuconostoc spp. Associated with Root Rot in Sugar Beet and Their Interaction with Rhizoctonia solani

A mixed infection of Leuconostoc lactis and vancomycin-resistant Enterococcus in a liver transplant recipient

Sepsis por Leuconostoc spp. en un lactante sano

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