Nosocomial outbreak of SARS-CoV-2 infection in a haematological unit – High mortality rate in infected patients with haematologic malignancies

Biernat, Monika; Zińczuk, Aleksander; Biernat, Paweł; Bogucka-Fedorczuk, Aleksandra; Kwiatkowski, J; Kalicińska, Elżbieta; Marciniak, Dominik; Simon, Krzysztof; Wróbel, Tomasz

doi:10.1016/j.jcv.2020.104574

Cited by 38 publications

(33 citation statements)

References 18 publications

(19 reference statements)

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“…Overall, our data show that in patients with Tx, a high mortality rate (83%) correlated with failure to control SARS-CoV-2 replication. High mortality (36.8%) in patients with hematologic disease and COVID-19 was also observed in other cohorts analyzing SARS-CoV-2 infection in this special patient cohort ( 4 ). All 24 patients had significant levels of SARS-CoV-2 RNA detectable in respiratory samples, but in contrast to previous studies ( 5 , 6 ), we could not find a correlation between the viral load in the respiratory tract at admission and mortality.…”

Section: Discussionsupporting

confidence: 78%

Viral Dynamics of SARS-CoV-2 in Critically Ill Allogeneic Hematopoietic Stem Cell Transplant Recipients and Immunocompetent Patients with COVID-19

Roedl

Heidenreich

Pfefferle

et al. 2021

Am J Respir Crit Care Med

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Conclusion: To our knowledge this is the first comprehensive report on COVID-19 in HSCT patients focussing on virological parameters. Compared to immunocompetent patients, prolonged shedding of infectious virus, viremia and high viral loads in respiratory samples, highlights the need of the immune system for viral control, but also indicates virus induced mortality and higher risk for transmission to other patients and medical staff.

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Section: Discussionsupporting

confidence: 78%

Viral Dynamics of SARS-CoV-2 in Critically Ill Allogeneic Hematopoietic Stem Cell Transplant Recipients and Immunocompetent Patients with COVID-19

Roedl

Heidenreich

Pfefferle

et al. 2021

Am J Respir Crit Care Med

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“…Such high inter- and intra-regional variability warrants further investigation, particularly in developed countries with similar SARS-CoV-2 incidence to Australia. Recent data from Iran 4 and Poland 24 support higher mortality of COVID-19 patients as a result of respiratory viral co-infections.…”

Section: Discussionmentioning

confidence: 96%

Respiratory viral co-infections among SARS-CoV-2 cases confirmed by virome capture sequencing

Kim

Deveson

Pang

et al. 2021

Sci Rep

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Accumulating evidence supports the high prevalence of co-infections among Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) patients, and their potential to worsen the clinical outcome of COVID-19. However, there are few data on Southern Hemisphere populations, and most studies to date have investigated a narrow spectrum of viruses using targeted qRT-PCR. Here we assessed respiratory viral co-infections among SARS-CoV-2 patients in Australia, through respiratory virome characterization. Nasopharyngeal swabs of 92 SARS-CoV-2-positive cases were sequenced using pan-viral hybrid-capture and the Twist Respiratory Virus Panel. In total, 8% of cases were co-infected, with rhinovirus (6%) or influenzavirus (2%). Twist capture also achieved near-complete sequencing (> 90% coverage, > tenfold depth) of the SARS-CoV-2 genome in 95% of specimens with Ct < 30. Our results highlight the importance of assessing all pathogens in symptomatic patients, and the dual-functionality of Twist hybrid-capture, for SARS-CoV-2 whole-genome sequencing without amplicon generation and the simultaneous identification of viral co-infections with ease.

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“…Patients with hematological malignancies are often in an immunocompromised state, and a high mortality due to COVID-19 in this population has recently been demonstrated, both in our group and elsewhere [ 1 , 2 ]. SARS-CoV-2 infection can complicate the course of standard treatment of hematologic malignancies by delaying subsequent cycles of chemotherapy, worsening the already severe prognosis in these patients [ 3 , 4 ].…”

Section: Introductionmentioning

confidence: 89%

Early Administration of Convalescent Plasma Improves Survival in Patients with Hematological Malignancies and COVID-19

Biernat

Kolasińska

Kwiatkowski

et al. 2021

Viruses

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The use of convalescent plasma in the treatment of COVID-19 may lead to a milder course of infection and has been associated with improved outcomes. Determining optimal treatments in high risk populations is crucial, as is the case in those with hematological malignancies. We analyzed a cohort of 23 patients with hematological malignancies and COVID-19 who had received plasma 48–72 h after the diagnosis of infection and compared it with a historical group of 22 patients who received other therapy. Overall survival in those who received convalescent plasma was significantly higher than in the historical group (p = 0.03460). The plasma–treated group also showed a significantly milder course of infection (p = 0.03807), characterized by less severe symptoms and faster recovery (p = 0.00001). In conclusion, we have demonstrated that convalescent plasma is an effective treatment and its early administration leads to clinical improvement, increased viral clearance and longer overall survival in patients with hematological malignancies and COVID-19. To our knowledge, this is the first report to analyze the efficacy of convalescent plasma in a cohort of patients with hematological malignancies.

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Nosocomial outbreak of SARS-CoV-2 infection in a haematological unit – High mortality rate in infected patients with haematologic malignancies

Abstract: Highlights Higher mortality rate in COVID-19 patients with haematologic diseases. Haematologic patients with COVID-19 have 50 % less chance of survival. Probability of death was higher in patients older than 40 yrs of age with AML/MDS.

Cited by 38 publications

References 18 publications

Viral Dynamics of SARS-CoV-2 in Critically Ill Allogeneic Hematopoietic Stem Cell Transplant Recipients and Immunocompetent Patients with COVID-19

Viral Dynamics of SARS-CoV-2 in Critically Ill Allogeneic Hematopoietic Stem Cell Transplant Recipients and Immunocompetent Patients with COVID-19

Respiratory viral co-infections among SARS-CoV-2 cases confirmed by virome capture sequencing

Early Administration of Convalescent Plasma Improves Survival in Patients with Hematological Malignancies and COVID-19

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