Nosocomial Infections in Pediatric Patients A European, Multicenter Prospective Study

Raymond, Josette; Aujard, Y.

doi:10.1086/501755

Cited by 384 publications

(325 citation statements)

References 19 publications

(8 reference statements)

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“…Abstracts for which there was no agreement as to the inclusion were analyzed jointly and the decision was made by consensus. Thus, 84 (80 articles and four theses) were ob-tained for detailed reading by the same two authors independently 27,28,29,30,31,32,33,34,35,36,37,38,39,40,41,42,43,44,45,46,47,48,49,50,51,52,53,54,55,56,57,58,59,60,61,62,63,64,65,66,67,68,69,70,71,72,73,74,75,76,77,…”

Section: Methodsmentioning

confidence: 99%

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Risk factors for healthcare-associated infection in pediatric intensive care units: a systematic review

et al. 2009

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Section: Methodsmentioning

confidence: 99%

“…Pneumonia is among the three main types of infection in the pediatric ICU and, as in adults, is more frequent among patients on mechanical ventilation 4,27,30,31,61 . The diagnosis of VAP, however, is challenging and may explain the differences in the diverse studies concerning the occurrence of this event as well as possible risk factors.…”

Section: Studymentioning

confidence: 99%

Risk factors for healthcare-associated infection in pediatric intensive care units: a systematic review

et al. 2009

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“…En niños estas infecciones presentan tasas elevadas al considerar etiologías virales respiratorias y gastrointestinales (rotavirus), y habitualmente reflejan la epidemiología estacional de la comunidad [2][3][4] . Así entonces, la internación de un niño a un centro hospitalario, debido a la vía de transmisión de rotavirus (habitualmente mano portada) y a su relativa facilidad de diseminación intrahospitalaria, conlleva un riesgo de adquisición de una rotavirosis nosocomial 5,6 .…”

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Comportamiento clínico y costos de la gastroenteritis por rotavirus en lactantes: Adquisición comunitaria versus nosocomial

2006

Rev. chil. infectol.

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EpidemiologíaComportamiento clínico y costos de la gastroenteritis por rotavirus en lactantes: Adquisición comunitaria versus nosocomial Luis Delpiano M., Joel Riquelme R, M. Cristina Casado F. y Ximena Álvarez H. Clinical features and costs of rotavirus gastroenteritis in infants:community versus nosocomialy acquired infection This is a prospective 12 month (July 2003-June 2004) cohort study in one large tertiary hospital of Santiago, Chile aimed to describe clinic features and calculate the direct costs of hospitalization associated to community-acquired (n = 78) and nosocomially-acquired (n = 52) rotavirus infection. A gastroenteritis severity score after Rennels 1996, (0 to 17 points) was applied and costs where calculated based on those assigned by the Chilean National Funds for Health (FONASA). Severe gastroenteritis manifested by a score > 14 occurred in 26.9% and 9.6% of community and nosocomially-acquired cases respectively (p < 0.015). The former had lower bicarbonate levels (p < 0.001), and required more volume expansion compared to the latter (p < 0.023). The average cost was US 277 per case for community acquired rotavirus and US 268 for nosocomial infection. In this hospital the cost of nosocomial rotavirus infection was ~ US$ 13,900 for a 12 month period. These results should stimulate the implementation of active prevention and control programs.

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“…The first national prevalence survey in Finland, conducted in 2005, identified E. coli, S. aureus and Enterococcus faecalis as the three most common pathogens causing HAIs in adult patients [42]. In pediatric studies, CoNS (20%-26%), Pseudomonas aeruginosa (5%-20%), S. aureus (11-15%), and Candida species (4%-9%) were predominant pathogens, in addition to viruses (mostly rotavirus and respiratory syncytial virus), which were identified in 22%-23% of all HAIs [43,44].…”

Section: N F E C T I O N V S C O L O N I Z a T I O Nmentioning

confidence: 99%

“…When the HAI rate was sorted by the age of the patients, the HAI rate in patients under two years of age (11.5 infections per 100 admissions) was substantially higher than in the other age groups (3.6 infections per 100 admissions in patients aged 2 to 4 years; 2.6 infections per 100 admissions in patients 5 years of age or older). A European study of 17 pediatric centers reported an overall HAI rate of 2.5% including five types of HAI: BSIs, lower respiratory tract infections, UTIs, SSIs, and gastrointestinal infections [44].…”

Section: Importance To Public Health M O R B I D I T Ymentioning

confidence: 99%

314 Healthcare-Associated Infections in Pediatrics

SpringerReference

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Helsinki 2008 P u b l i c a t i o n s o f t h e N a t i o n a l P u b l i c H e a l t h I n s t i t u t e K T L A 1 1 / 2 0 0 8 Dr. Alexander Langmuir, 1963 Emmi Sarvikivi, Healthcare-associated infections in pediatrics Publications of the National Public Health Institute, A11/2008, 93 Pages ISBN 978-951-740-803-5; 978-951-740-804-2 (pdf-version) ISSN 0359-3584; 1458-6290 (pdf-version) http://www.ktl.fi/portal/4043 ABSTRACT Background and aims. Healthcare-associated infections (HAIs) are known to increase the risk for patient morbidity and mortality in different healthcare settings and thereby to cause additional costs. HAIs typically affect patients with severe underlying conditions, such as patients treated in intensive care units, or patients who have undergone medical procedures, e.g., surgery. HAIs are prevalent also among pediatric patients, but the distribution of the types of infection and the causative agents differ from those detected in adults. The aim of this study was to obtain information on pediatric HAIs in Finland through an assessment of the surveillance of bloodstream infections (BSIs), through two outbreak investigations in a neonatal intensive care unit (NICU), and through a study of postoperative HAIs after open-heart surgery.Methods. The Hospital for Children and Adolescents of the Helsinki University Central Hospital has participated in the BSI surveillance of the Finnish Hospital Infection Program since 1999. These data were utilized in all studies. The epidemiological features of pediatric BSIs were assessed. For the outbreak investigations, case definitions were set and data collected from microbiological and clinical records. The antimicrobial susceptibilities of the Serratia marcescens and the Candida parapsilosis isolates were determined. The S. marcescens isolates were genotyped with pulsed-field gel electrophoresis and the C. parapsilosis blood culture isolates (obtained between the years 1990 and 2002) with Southern blot hybridization by use of a DNA fingerprinting probe. Patient charts were reviewed for the case-control and cohort studies during the outbreak investigations, as well as for those patients who acquired surgical site infections (SSIs) after having undergone open-heart surgery. Also a prospective postdischarge study was conducted to detect postoperative HAIs after open-heart surgery.Results. During 1999During -2006, the overall annual BSI rate was 1.6/1,000 patient-days (range by year, 1.2-2.1). High rates (average, 4.9 and 3.2 BSIs/1,000 patient-days) were detected in hematology and neonatology units. Coagulase-negative staphylococci were the most common pathogens both hospital-wide and in each patient group. The overall mortality was 5%. The genotyping of the 15 S. marcescens isolates revealed three independent clusters. All of the 26 C. parapsilosis isolates studied proved to be indistinguishable. No common source was identified for either of the outbreaks, but the NICU was overcrowded during the S. marcescens clusters. In both investigations, low birth we...

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Nosocomial Infections in Pediatric Patients A European, Multicenter Prospective Study

Cited by 384 publications

References 19 publications

Risk factors for healthcare-associated infection in pediatric intensive care units: a systematic review

Risk factors for healthcare-associated infection in pediatric intensive care units: a systematic review

Comportamiento clínico y costos de la gastroenteritis por rotavirus en lactantes: Adquisición comunitaria versus nosocomial

314 Healthcare-Associated Infections in Pediatrics

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