“…It is likely that more severely ill neonates required the use of both a ventilator and a catheter, but unmeasured factors such as preexisting colonization of the respiratory tract with potential pathogens may have increased the risk for CR BSI, as has been noted for candidemia. 24,25 In this study population, CR BSI were more likely than non-CR BSI to be caused by grampositive than gram-negative organisms. Gram-positive skin flora may be more likely to colonize the catheter during catheter insertion and use, whereas infections with gram-negative organisms may be more commonly associated with translocation of flora from the gut or respiratory or urinary tract.…”