Nosocomial Candiduria in the Elderly: Microbiological Diagnosis

García-Agudo, Lidia; Rodríguez-Iglesias, Manuel; Carranza-González, Rafael

doi:10.1007/s11046-017-0232-7

Cited by 9 publications

(7 citation statements)

References 30 publications

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“…Previous studies have produced mixed results on which Candida species is more likely to cause UTIs. C. albicans, 25 C. tropicalis 26,27 and C. glabrata 19 have been, respectively, considered to be more associated with urinary infection in the different reports. Thus, the differentiation of Candida species distribution of urinary Candida colonization and infection is an issue worthy of discussion in future clinical research.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of a Novel Laboratory Candiduria Screening Protocol in the Intensive Care Unit

He¹,

Su²,

Bi³

et al. 2021

IDR

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Background: Since urine cultures are only guaranteed for patients with obvious urinary symptoms in most cases, most of candiduria episodes are ignored in clinic. Objective: This study aimed to design a screening protocol to improve diagnostic efficiency of candiduria, and provide information of Candida species and drug susceptibility. Methods: All patients, who were admitted to the intensive care unit (ICU) of our hospital during December 1, 2018 and October 1, 2019, were enrolled in this study. Urinalysis was performed every three days for each subject from the first day of ICU admission. Urine specimens were sampled for fungal culture with either condition: (1) yeast-like cell counting (YLCC) ≥200; (2) positive YLCCs were observed in two consecutive tests, and at least one YLCC ≥100. Results: The screening protocol dramatically improved the candiduria diagnostic rate of ICU patients from 2.28% to 17.27%. However, compared to the historical control, the screening protocol has no time-saving advantage in candiduria diagnosing. Higher percentage of C. albicans in screening protocol-identified candiduria patients was observed, although there was no statistical difference. Our results indicated that female gender, pneumonia, diabetes and infarction/hemorrhage patients were more prone to develop candiduria. Non-candiduria patients showed a better tendency for survival and shorter ICU stay length. Multisite colonization was common in the surveyed candiduria patients, who were up to 70.83% showed Candida positive cultures in sputum. Conclusion: The screening protocol established in the study was a convenient and practical tool for early warning and feasible management of candiduria and IC.

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Section: Discussionmentioning

confidence: 99%

Evaluation of a Novel Laboratory Candiduria Screening Protocol in the Intensive Care Unit

He¹,

Su²,

Bi³

et al. 2021

IDR

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“…Con respecto a la población hospitalizada (51,28%) las especies más frecuentemente recuperadas de urocultivos fueron C. no-albicans con el 70%, superior a la frecuencia encontrada por Jacobsy col. (2017) 13 , en dicho estudio realizado en muestras de orina de pacientes hospitalizados, el 54,4% de aislamientos correspondieron a especies no-albicans. Al comparar las especies aisladas, se obtuvo que C. albicans fue la más frecuente con un 38,5%, seguida por C. tropicalis (23,1%) y C. glabrata (21,8%), estos resultados son similares a un estudio español de Garcíay col. (2015) 14 quienes incluyeron 266 urocultivos positivos para Candida spp. , en este estudio la identificación de especie fue realizada mediante el sistema ID32C ® (BioMérieux, Francia), los autores encontraron una frecuencia de 9% de aislamientos de C. albicans, seguido por C. glabrata (19,5%) y C. tropicalis (17,7%).…”

Section: Discussionunclassified

Caracterización de Candida spp. aisladas a partir de urocultivos en la ciudad de Medellín

Duque

Sánchez

Gaviria

et al. 2020

Infect

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Candida spp. es un agente etiológico importante en infecciones del tracto urinario, principalmente en población con terapia antimicótica de amplio espectro y con catéteres urinarios. Candida albicans es la especie más frecuente, pero otras especies han surgido como patógenos emergentes. En este trabajo se recolectaron aislamientos de Candida spp. de urocultivos de pacientes que consultaron en Dinamica IPS entre enero 2016 y noviembre 2017. Para estimar la frecuencia de las especies y observar los patrones de sensibilidad, se realizó la identificación fenotípica y su perfil de sensibilidad con el sistema comercial Vitek 2® (BioMérieux, Inc.), adicionalmente se evaluaron mediante análisis de las secuencia y filogenética ITS1-5.8S-ITS2. En el estudio se incluyeron 78 aislamientos de Candida spp. Las frecuencias de especies de Candida identificadas empleando las herramientas moleculares fueron: C. albicans (38,5%), C. tropicalis (23,1%), C. glabrata (21,8%), C. parapsilosis (10,3%), C. metapsilosis y C. krusei (2,5%) y C. guillermondi (1,3%). La identificación por métodos moleculares y por el sistema Vitek 2 fue: C. albicans (93,3%), C. glabrata (94,1 %), C. tropicalis (83,3%), C. parapsilosis (75%) C. guilliermondii y C. krusei (100%). La sensibilidad de todos los aislamientos al fluconazol fue 93,6%.

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“…These 30 articles included description of 45 studies related to different yeast species with QPS status, of which 16 referred to Candida kefyr (teleomorph = Kluyveromyces marxianus ) (Afsarian et al., ; Awad et al., ; Bharathi, ; Diba et al., ; García‐Agudo et al., ; Hasan and Yassein, ; Kaur et al., ; Kesmen et al., ; Khedri et al., ; Nagy et al., ; Okmen et al., ; Omran and Mansori, ; de Paula et al., ; Sadrossadati et al., ; Shokohi et al., ; Simi et al., ), 8 to Saccharomyces cerevisiae including Saccharomyces boulardii (corresponding to 7 articles: Lazo‐Vélez et al., ; Ruelle et al., ; Hasan and Yassein, ; Kara et al., ; Kesmen et al., ; Ochiai et al., ; Teblick et al., ), 10 to Candida famata (teleomorph = Debaryomyces hansenii ) (Afsarian et al., ; Alobaid and Khan, ; Awad et al., ; Cen et al., ; Das et al., ; Diba et al., ; Hasan and Yassein, ; Kesmen et al., ; de Paula et al., ; Simi et al., ), 6 to Candida pelliculosa (synonymus = Pichia anomala , teleomorph = Wickerhamomyces anomalus ) (Ahmadsah et al., ; Arendrup et al., ; Cen et al., ; Jung et al., ; Kesmen et al., ; Soman et al., ), 1 to Candida utilis (teleomorph = Lindnera jadinii ) (Treguier et al., ), 1 to Hanseniaspora uvarum (Kesmen et al., ), 1 Kluyveromyces lactis (Kesmen et al., ) a nd 1 to Schizosaccharomyces pombe (Kesmen et al., ). One of these articles was considered relevant (Pfaller et al., ) to evaluate since it presented new data on antimycotic MIC breakpoints for azoles but it is not associated to any specific yeast TU.…”

Section: Assessmentmentioning

confidence: 99%

Update of the list of QPS‐recommended biological agents intentionally added to food or feed as notified to EFSA 10: Suitability of taxonomic units notified to EFSA until March 2019

Koutsoumanis¹,

Allende²,

Álvarez‐Ordóñez³

et al. 2019

EFS2

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The qualified presumption of safety (QPS) procedure was developed to provide a harmonised generic preevaluation to support safety risk assessments of biological agents performed by EFSA's Scientific Panels. The taxonomic identity, body of knowledge, safety concerns and antimicrobial resistance were assessed. Safety concerns identified for a taxonomic unit (TU) are, where possible and reasonable in number, reflected by 'qualifications' which should be assessed at the strain level by the EFSA's Scientific Panels. During the current assessment, no new information was found that would change the previously recommended QPS TUs and their qualifications. The list of microorganisms notified to EFSA from applications for market authorisation was updated with 47 biological agents, received between October 2018 and March 2019. Of these, 19 already had QPS status, 20 were excluded from the QPS exercise by the previous QPS mandate (11 filamentous fungi) or from further evaluations within the current mandate (9 notifications of Escherichia coli). Sphingomonas elodea, Gluconobacter frateurii, Corynebacterium ammoniagenes, Corynebacterium casei, Burkholderia ubonensis, Phaeodactylum tricornutum, Microbacterium foliorum and Euglena gracilis were evaluated for the first time. Sphingomonas elodea cannot be assessed for a possible QPS recommendation because it is not a valid species. Corynebacterium ammoniagenes and Euglena gracilis can be recommended for the QPS list with the qualification 'for production purposes only'. The following TUs cannot be recommended for the QPS list: Burkholderia ubonensis, due to its potential and confirmed ability to generate biologically active compounds and limited of body of knowledge; Corynebacterium casei, Gluconobacter frateurii and Microbacterium foliorum, due to lack of body of knowledge; Phaeodactylum tricornutum, based on the lack of a safe history of use in the food chain and limited knowledge on its potential production of bioactive compounds with possible toxic effects.

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Nosocomial Candiduria in the Elderly: Microbiological Diagnosis

Cited by 9 publications

References 30 publications

Evaluation of a Novel Laboratory Candiduria Screening Protocol in the Intensive Care Unit

Evaluation of a Novel Laboratory Candiduria Screening Protocol in the Intensive Care Unit

Caracterización de Candida spp. aisladas a partir de urocultivos en la ciudad de Medellín

Update of the list of QPS‐recommended biological agents intentionally added to food or feed as notified to EFSA 10: Suitability of taxonomic units notified to EFSA until March 2019

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