Nosocomial bloodstream infection caused by Pseudomonas alcaligenes in a preterm neonate from Mérida, Venezuela

Flores-Carrero, Ana; Paniz‐Mondolfi, Alberto; Araque, Marı́a

doi:10.4103/2249-4847.179932

Cited by 5 publications

(2 citation statements)

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“…alcaligenes inhabits various environments, including soils and waters, can degrade certain organic substances and is used for bioremediation of oil pollution [14]. P. alcaligenes is rarely pathogenic in humans, although at least four reports have described infections in humans caused by P. alcaligenes, including endocarditis related to a history of rheumatic fever [15], catheter-related endocarditis after bone marrow transplantation [16], nosocomial bloodstream infection in a preterm neonate [17] and bloodstream infection in a patient with Guillain-Barré syndrome [9]. Clinical isolates of P. alcaligenes have been reported to produce MBLs, including VIM-2 [18] and PAM-1, a subclass B3 MBL [9].…”

Section: Introductionmentioning

confidence: 99%

“…alcaligenes is rarely pathogenic in humans, although at least four reports have described infections in humans caused by P. alcaligenes , including endocarditis related to a history of rheumatic fever [15], catheter-related endocarditis after bone marrow transplantation [16], nosocomial bloodstream infection in a preterm neonate [17] and bloodstream infection in a patient with Guillain-Barré syndrome [9]. Clinical isolates of P.…”

Section: Introductionmentioning

confidence: 99%

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Emergence of carbapenem-resistant Pseudomonas alcaligenes and Pseudomonas paralcaligenes clinical isolates with plasmids harbouring bla IMP-1 in Japan

Ono

Tohya

Tada

et al. 2023

Journal of Medical Microbiology

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Introduction. The emergence of carbapenem-resistant Pseudomonas species producing metallo-β-lactamase (MBL) has become a serious medical problem worldwide. IMP-type MBL was firstly detected in 1991 in Japan. Since then, it has become one of the most prevalent types of MBLs. Hypothesis/Gap statement. Avirulent species of Pseudomonas , such as Pseudomonas alcaligenes , function as reservoirs of drug resistance-associated genes encoding carbapenemases in clinical settings. Methodology. Active surveillance for carbapenem-resistant Gram-negative pathogens was conducted in 2019 at a hospital in Tokyo, Japan. Of the 543 samples screened for carbapenem-resistant isolates, 2 were species of Pseudomonas . One was from a stool sample from a medical staff member, and the other was from a stool sample from a hospitalized patient. Results. Whole-genome sequencing showed that the former isolate was a strain of P. alcaligenes , and the latter was a strain of Pseudomonas paralcaligenes, a species close to P. alcaligenes . Both isolates were resistant to all carbapenems and harboured bla IMP-1 genes encoding IMP-1 MBL, which conferred resistance to carbapenems. The bla IMP-1 genes of P. alcaligenes and P. paralcaligenes were located on the plasmids, pMRCP2, 323125 bp in size, and pMRCP1333, 16592 bp in size, respectively. The sequence of 82 % of pMRCP2 was 92 % similar to the sequence of a plasmid of P. aeruginosa PA83, whereas the sequence of 79 % of pMRCP1333 was >95 % similar to the sequence of a plasmid of Achromobacter xylosoxidans FDAARGOS 162. The genomic environments surrounding the bla IMP-1 of pMRCP2 and pMRCP1333 differed completely from each other. Conclusions. These results indicate that the two isolates acquired bla IMP-1 from different sources and that P. alcaligenes and P. paralcaligenes function as vectors and reservoirs of carbapenem-resistant genes in hospitals.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Emergence of carbapenem-resistant Pseudomonas alcaligenes and Pseudomonas paralcaligenes clinical isolates with plasmids harbouring bla IMP-1 in Japan

Ono

Tohya

Tada

et al. 2023

Journal of Medical Microbiology

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Characterization of Pathogenic Pseudomonas alcaligenes Isolated from Koi Carp in China

Bai

Huo

et al. 2021

J Aqua Anim Hlth

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Pseudomonas alcaligenes infection is rare in aquaculture. In this study, we provide the first report on the characterization of P. alcaligenes from koi (a variant of Common Carp Cyprinus carpio) in China. A gram‐negative bacterium was isolated from the diseased koi and was named KCP‐516. Morphological and biochemical tests as well as phylogenetic tree analyses derived from 16S ribosomal RNA, gyrase subunit A, and gyrase subunit B gene sequencing all strongly indicated that the isolate KCP‐516 was P. alcaligenes. In liquid medium, the optimal growth conditions were 25°C, 2.5% NaCl, and pH 8. The pathogenicity of the isolate was demonstrated in koi, with 7.0 × 104 CFU/g fish weight identified as the dose lethal to 50% of test fish. The results will provide a scientific reference for the diagnosis and treatment of P. alcaligenes infection.

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Comparative study on the microbial quality in the swimming pools disinfected by the ozone-chlorine and chlorine processes in Tabriz, Iran

Firuzi

Hashemi

Kafil

et al. 2020

Environ Monit Assess

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Nosocomial bloodstream infection caused by Pseudomonas alcaligenes in a preterm neonate from Mérida, Venezuela

Cited by 5 publications

References 1 publication

Emergence of carbapenem-resistant Pseudomonas alcaligenes and Pseudomonas paralcaligenes clinical isolates with plasmids harbouring bla IMP-1 in Japan

Emergence of carbapenem-resistant Pseudomonas alcaligenes and Pseudomonas paralcaligenes clinical isolates with plasmids harbouring bla IMP-1 in Japan

Characterization of Pathogenic Pseudomonas alcaligenes Isolated from Koi Carp in China

Comparative study on the microbial quality in the swimming pools disinfected by the ozone-chlorine and chlorine processes in Tabriz, Iran

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