Noscapine Loaded PLGA Nanoparticles Prepared Using Oil-in-Water Emulsion Solvent Evaporation Method

Yadav, Kuldeep; Yadav, Deepak Kumar; Yadav, Madhu; Kumar, Sunil

doi:10.1166/jnd.2015.1074

Cited by 9 publications

(4 citation statements)

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“…This study demonstrates the development of stable HSA-NPs using the emulsion-solvent evaporation method. This method is commonly used for improving the solubility of hydrophobic drugs by attachment to HSA-NPs or other polymeric nanoparticles [ 29 , 30 ]. As compared to other preparation methods, such as the pH coacervation method, this process is less complex, less time consuming and suitable for scale up [ 31 ].…”

Section: Discussionmentioning

confidence: 99%

Human Serum Albumin Nanoparticles for Use in Cancer Drug Delivery: Process Optimization and In Vitro Characterization

Lomis¹,

Westfall²,

Farahdel³

et al. 2016

Nanomaterials

137

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Human serum albumin nanoparticles (HSA-NPs) are widely-used drug delivery systems with applications in various diseases, like cancer. For intravenous administration of HSA-NPs, the particle size, surface charge, drug loading and in vitro release kinetics are important parameters for consideration. This study focuses on the development of stable HSA-NPs containing the anti-cancer drug paclitaxel (PTX) via the emulsion-solvent evaporation method using a high-pressure homogenizer. The key parameters for the preparation of PTX-HSA-NPs are: the starting concentrations of HSA, PTX and the organic solvent, including the homogenization pressure and its number cycles, were optimized. Results indicate a size of 143.4 ± 0.7 nm and 170.2 ± 1.4 nm with a surface charge of −5.6 ± 0.8 mV and −17.4 ± 0.5 mV for HSA-NPs and PTX-HSA-NPs (0.5 mg/mL of PTX), respectively. The yield of the PTX-HSA-NPs was ~93% with an encapsulation efficiency of ~82%. To investigate the safety and effectiveness of the PTX-HSA-NPs, an in vitro drug release and cytotoxicity assay was performed on human breast cancer cell line (MCF-7). The PTX-HSA-NPs showed dose-dependent toxicity on cells of 52%, 39.3% and 22.6% with increasing concentrations of PTX at 8, 20.2 and 31.4 μg/mL, respectively. In summary, all parameters involved in HSA-NPs’ preparation, its anticancer efficacy and scale-up are outlined in this research article.

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Section: Discussionmentioning

confidence: 99%

Human Serum Albumin Nanoparticles for Use in Cancer Drug Delivery: Process Optimization and In Vitro Characterization

Lomis¹,

Westfall²,

Farahdel³

et al. 2016

Nanomaterials

137

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“…An emulsion-solvent evaporation technique was developed to synthesize the NPs having varying densities of curdlan (2, 5 and 8% w/w). 15 – 18 Briefly, 2 mL of a 1% w/v polymer solution (mixture of C-PLGA and PLGA) in a DMSO: DCM mixture (1:9) was added drop-wise to 10 mL of a PVA solution in de-ionised water (0.5% w/v) under probe sonication (Bandelin Sonoplus UW2070 + HD 2070 Berlin, Germany) for 7 min, 55% power, 70 Watt). A mixture of C-PLGA and PLGA was used to produce the desired concentration of curdlan functionalized NPs.…”

Section: Methodsmentioning

confidence: 99%

Physicochemical and Biological Evaluation of Curdlan-Poly(Lactic-Co-Glycolic Acid) Nanoparticles as a Host-Directed Therapy Against Mycobacterium Tuberculosis

D’Souza

Plessis

Egieyeh

et al. 2022

Journal of Pharmaceutical Sciences

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This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

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“…Subsequently, the evaporation of the emulsion internal phase by stirring takes place. Serval examples of micro and nanoparticles obtained with the O/W methodology for lipophilic drugs, such as donepezil [64], noscapine [65] or steroids are reported. Gonzales et al developed poly(lactic-co-glycolic acid) nanoparticles containing turmeric compounds (turmeric-PLGA-NPs) using emulsion-solvent evaporation demonstrating the ability of producing NPs in the range of 145 nm with a low polydispersity index (PdI) in size distribution and zeta potential of −21.8 mV.…”

Section: Single Emulsion Techniquementioning

confidence: 99%

Recent Fabrication Methods to Produce Polymer-Based Drug Delivery Matrices (Experimental and In Silico Approaches)

et al. 2022

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The study of novel drug delivery systems represents one of the frontiers of the biomedical research area. Multi-disciplinary scientific approaches combining traditional or engineered technologies are used to provide major advances in improving drug bioavailability, rate of release, cell/tissue specificity and therapeutic index. Biodegradable and bio-absorbable polymers are usually the building blocks of these systems, and their copolymers are employed to create delivery components. For example, poly (lactic acid) or poly (glycolic acid) are often used as bricks for the production drug-based delivery systems as polymeric microparticles (MPs) or micron-scale needles. To avoid time-consuming empirical approaches for the optimization of these formulations, in silico-supported models have been developed. These methods can predict and tune the release of different drugs starting from designed combinations. Starting from these considerations, this review has the aim of investigating recent approaches to the production of polymeric carriers and the combination of in silico and experimental methods as promising platforms in the biomedical field.

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Noscapine Loaded PLGA Nanoparticles Prepared Using Oil-in-Water Emulsion Solvent Evaporation Method

Cited by 9 publications

References 0 publications

Human Serum Albumin Nanoparticles for Use in Cancer Drug Delivery: Process Optimization and In Vitro Characterization

Human Serum Albumin Nanoparticles for Use in Cancer Drug Delivery: Process Optimization and In Vitro Characterization

Physicochemical and Biological Evaluation of Curdlan-Poly(Lactic-Co-Glycolic Acid) Nanoparticles as a Host-Directed Therapy Against Mycobacterium Tuberculosis

Recent Fabrication Methods to Produce Polymer-Based Drug Delivery Matrices (Experimental and In Silico Approaches)

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