Norwegian scabies presenting as erythroderma

Mehta, Vandana; Balachandran, C; Monga, Puja; Rao, Raghavendra; Rao, Lakshmi

doi:10.4103/0378-6323.57726

Cited by 10 publications

(9 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The unique, intraepithelial‐predominant distribution of histoplasmosis in the current case further bears some resemblance to the phenomenon seen in crusted or so‐called ‘Norwegian’ scabies, in which the epidermis is colonized by innumerable female Sarcoptes scabiei mites . Norwegian scabies is commonly associated with prolonged use of systemic or topical corticosteroids, HIV/AIDS and chronic systemic diseases, prompting the suggestion that the uncontrolled proliferation of scabies mites in the epidermis in Norwegian scabies arises because of a failure of the cell‐mediated immune response. Additional risk factors include sensory neuropathy, paresis, immobility, mental illness, and extremes of age, all of which compromise the infected patient's ability to sense, scratch and mechanically destroy mite borrows, resulting in their progressive vertical accumulation.…”

Section: Discussionmentioning

confidence: 55%

“…Norwegian scabies is commonly associated with prolonged use of systemic or topical corticosteroids, HIV/AIDS and chronic systemic diseases, prompting the suggestion that the uncontrolled proliferation of scabies mites in the epidermis in Norwegian scabies arises because of a failure of the cell‐mediated immune response. Additional risk factors include sensory neuropathy, paresis, immobility, mental illness, and extremes of age, all of which compromise the infected patient's ability to sense, scratch and mechanically destroy mite borrows, resulting in their progressive vertical accumulation. Clinically, Norwegian scabies is characterized by extensive hyperkeratosis and crusting of the skin and erythroderma, especially on acral sites – more extensive than that seen in the current case …”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Cutaneous histoplasmosis with prominent parasitization of epidermal keratinocytes: report of a case

et al. 2016

View full text Add to dashboard Cite

Disseminated histoplasmosis most commonly occurs in immunosuppressed individuals and involves the skin in approximately 6% of patients. Cutaneous histoplasmosis with an intraepithelial-predominant distribution has not been described. A 47-year-old man was admitted to our institution with fever and vancomycin-resistant enterococcal bacteremia. He had been diagnosed with T-cell prolymphocytic leukemia 4 years earlier and had undergone matched-unrelated-donor stem cell transplant 2 years earlier; on admission, he had relapsed disease. His medical history was significant for disseminated histoplasmosis 6 months before admission, controlled with multiple antifungal regimens. During this final hospitalization, the patient developed multiple 2-5 mm erythematous papules, a hemorrhagic crust across the chest, shoulders, forearms, dorsal aspect of the fingers, abdomen and thighs. Skin biopsy revealed clusters of oval yeast forms mostly confined to the cytoplasm of keratinocytes and within the stratum corneum; scattered organisms were present in the underlying superficial dermis without any significant associated inflammatory infiltrate. Special stains and immunohistochemical studies confirmed these to be Histoplasma organisms. We highlight this previously unrecognized pattern of cutaneous histoplasmosis to ensure its prompt recognition and appropriate antifungal therapy.

show abstract

Section: Discussionmentioning

confidence: 55%

Section: Discussionmentioning

confidence: 99%

Cutaneous histoplasmosis with prominent parasitization of epidermal keratinocytes: report of a case

et al. 2016

View full text Add to dashboard Cite

show abstract

“…The etiology and peculiarities of the disease evolution have been quite competently systemized [5,7]. For the last two decades the cases of Norwegian scabies have been described in HIV-infected patients [8][9][10][11], in elderly and disabled people [12,13] and rarely observed in cases of brain astrozytoma [14], drug addiction [15], Down syndrome, diffuse fatty liver disease, anemia, parenchymatous dystrophy of visceral organs, cachexia [16], bullous pemphigoid treated with systemic c orticosteroids [17], congenital erythroderma [18], in patients taking novel immunosuppressive agents tozilisumab [19] and cyclosporine [20], in case of skin exposure to pesticides [21]. Rare cases of Norwegian scabies are also described without associated pathology: in a 24-year-old man [22], in a pregnant woman [23], in children [24,25].…”

Section: Introductionmentioning

confidence: 99%

“…Erythroderma is the second diagnostically relevant symptom of Norwegian scabies [6,13,16,[26][27][28][29][30][31]. The cause of erythroderma in this case is considered to be Staphylococcus aureus colonizing mite burrows [32,33].…”

Section: Introductionmentioning

confidence: 99%

Scabious erythroderma – a rare clinical variant of scabies

Sokolova¹,

Adaskevich²,

Malyarchuk³

et al. 2019

Our Dermatol Online

View full text Add to dashboard Cite

Background: Erythroderma (exfoliative dermatitis) is an emergency condition in dermatology in which not less than 90% of skin surface is affected. The presenting features are erythema, skin scaling and itching, fever and lymphadenopathy. The most common cause of erythroderma is a preexisting dermatosis (psoriasis, atopic dermatitis, eczema, seborheic dermatitis, lichen rubra pilaris, lichen planus, pemphigus foliaceous), drug reactions, lymphoma, leukemia and visceral neoplasias. Erythroderma is a diagnostically relevant presenting feature of Norwegian scabies. The aim of investigation: Is to describe clinical peculiarities of scabious erythroderma as a special rare form of scabies, to assess the number of scabies mites on the patient and in his/her environment and to work out the criteria of differential diagnosis with Norwegian scabies. Material and methods: We examined 5 patients with scabies and erythroderma as the main presenting feature. All patients were women aged from 42 to 89 years. The disease duration was from 8 months to 1 year. The causes of erythroderma were variable. Clinical and paraclinical methods of investigation alongside with dermatoscopy and microscopy were used. Results This is the description of a rare clinical form of scabies, scabious erythroderma. It is based on the analysis of the 5 cases of scabies, whose main clinical manifestation is diffuse erythroderma. The diagnostic criterias of scabious erythroderma and differential diagnosis of Norwegian scabies are given. The invasive potential of this form of the disease on the patient and beyond is evaluated for the first time.

show abstract

“…A highly contagious form is the crusted and hyperkeratotic variant (‘Norwegian’ scabies). [12] This form can often present as erythroderma[3] and can be missed if a simple investigation like skin scraping is not undertaken.…”

mentioning

confidence: 99%