“…Since the discovery of thapsigargin in 1978 (Rasmussen, Brøgger Christensen & Sandberg, ) and its pharmaceutical properties in 1984 (Christensen et al ., ), Thapsia has been subject to chemical investigations searching for new specialized metabolites with drug lead potential. This has resulted in numerous publications on the chemistry and chemotaxonomy of Thapsia (Rasmussen, Christensen & Sandberg, ; Lemmich, Jensen & Rasmussen, ; Teresa et al ., 1985a, b, c, d, 1986a, b, c; Falsone, Haddad & Wendisch, ; Smitt et al ., , 1990a, b, ; Avato, ; Lemmich et al ., ; Smitt & Christensen, ; Avato, Jacobsen & Smitt, ; Smitt, ; Avato, Trabace & Smitt, ; Christensen, Andersen & Smitt, ; Avato & Smitt, ; Avato, Fanizzi & Rosito, ; Avato & Rosito, ; Liu, Olsen & Christensen, ; Rubal et al ., , , , ; Saouf et al ., 2005; 2006; Liu HZ et al ., ; Drew et al ., ; Goncalves et al ., ). However, our understanding of the chemical diversity of Thapsia has been complicated by the taxonomic complexity of the genus.…”