Northwest Siberian Khanty and Mansi in the junction of West and East Eurasian gene pools as revealed by uniparental markers

Pimenoff, Ville N.; Comas, David; Palo, Jukka U.; Vershubsky, Galina; Kozlov, Andrei P.; Sajantila, Antti

doi:10.1038/ejhg.2008.101

Cited by 54 publications

(37 citation statements)

References 51 publications

(46 reference statements)

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“…47,48 Regional differences in Finland have also been reported. 4 -7,12,49 This study, a rather straightforward haplotype-level population genetic analysis, corroborated this picture.…”

Section: Discussionmentioning

confidence: 99%

“…It is possible that, at some stage, the majority of the males in this prehistoric population carried the Y chromosomes of haplogroup N3. 48 The subsequent Scandinavian gene flow has then affected the genetic composition of the southwestern as well as the northernmost parts of Finland only, creating the large Y-chromosomal differences between western and eastern parts of the country. In other words, the Scandinavian influence can be seen as an additional genetic element in the ESA region (and Lapland), whereas the Finno-Ugric genetic component remains still more prominent in the east of Finland.…”

Section: Finland Revisitedmentioning

confidence: 99%

“…This is reflected in the haplogroup distribution: the Scandinavian haplogroup I occurs with frequencies 430% only in western Finland. 4 Haplogroup N3, typical for Fenno-Ugric populations of north-eastern Europe, 48,50 is observed in all parts of Finland but reaches high frequencies (B79%) only in eastern Finland. The interregional dichotomy results in large F ST estimates between eastern and western Finland and, consequently, in the clustering of populations (Figures 3 and 4).…”

Section: Gene Flow From Scandinaviamentioning

confidence: 99%

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Genetic markers and population history: Finland revisited

et al. 2009

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The Finnish population in Northern Europe has been a target of extensive genetic studies during the last decades. The population is considered as a homogeneous isolate, well suited for gene mapping studies because of its reduced diversity and homogeneity. However, several studies have shown substantial differences between the eastern and western parts of the country, especially in the male-mediated Y chromosome. This divergence is evident in non-neutral genetic variation also and it is usually explained to stem from founder effects occurring in the settlement of eastern Finland as late as in the 16th century. Here, we have reassessed this population historical scenario using Y-chromosomal, mitochondrial and autosomal markers and geographical sampling covering entire Finland. The obtained results suggest substantial Scandinavian gene flow into south-western, but not into the eastern, Finland. Male-biased Scandinavian gene flow into the south-western parts of the country would plausibly explain the large interregional differences observed in the Y-chromosome, and the relative homogeneity in the mitochondrial and autosomal data. On the basis of these results, we suggest that the expression of 'Finnish Disease Heritage' illnesses, more common in the eastern/north-eastern Finland, stems from long-term drift, rather than from relatively recent founder effects.

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“…47,48 Regional differences in Finland have also been reported. 4 -7,12,49 This study, a rather straightforward haplotype-level population genetic analysis, corroborated this picture.…”

Section: Discussionmentioning

confidence: 99%

Section: Finland Revisitedmentioning

confidence: 99%

Section: Gene Flow From Scandinaviamentioning

confidence: 99%

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Genetic markers and population history: Finland revisited

et al. 2009

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“…Y chromosomal haplogroups were combined into groups C, D, E, F, I, J2, K, L, N1c, PxR1a and R1a, so that published sources could be used for comparisons (Bosch et al 2006;Cinnioglu et al 2004;Di Gaetano et al 2009;Hammer et al 2006;Kayser et al 2005;Maca-Meyer et al 2003;Malhi et al 2008;Nasidze et al 2002Nasidze et al , 2005Pericić et al 2005a, b;Petrejcíková et al 2010;Pimenoff et al 2008;Rosser et al 2000;Semino et al 2000;Tambets et al 2004;Völgyi et al 2009;Wells et al 2001;Xue et al 2006;Zastera et al 2010).…”

Section: Methods For Genetic Analysismentioning

confidence: 99%

“…To compare maternal lineages, we used published mtDNA haplogroup frequencies Bosch et al 2006;Brandstätter et al 2007;Comas et al 2004;Derbeneva et al 2002;Helgason et al 2001;Irwin et al 2007;Maca-Meyer et al 2003;Malyarchuk et al 2002;Merriwether et al 1996;Pakendorf et al 2007;Passarino et al 2002;Pericić et al 2005a;Pimenoff et al 2008;Quintana-Murci et al 2004;Simoni et al 2000;Starikovskaya et al 2005;Yao et al 2004; http://www. eupedia.com).…”

Section: Methods For Genetic Analysismentioning

confidence: 99%

A comparative phylogenetic study of genetics and folk music

Pamjav¹,

Juhász

Zalán³

et al. 2012

Mol Genet Genomics

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Computer-aided comparison of folk music from different nations is one of the newest research areas. We were intrigued to have identified some important similarities between phylogenetic studies and modern folk music. First of all, both of them use similar concepts and representation tools such as multidimensional scaling for modelling relationship between populations. This gave us the idea to investigate whether these connections are merely accidental or if they mirror population migrations from the past. We raised the question; does the complex structure of musical connections display a clear picture and can this system be interpreted by the genetic analysis? This study is the first to systematically investigate the incidental genetic background of the folk music context between different populations. Paternal (42 populations) and maternal lineages (56 populations) were compared based on Fst genetic distances of the Y chromosomal and mtDNA haplogroup frequencies. To test this hypothesis, the corresponding musical cultures were also compared using an automatic overlap analysis of parallel melody styles for 31 Eurasian nations. We found that close musical relations of populations indicate close genetic distances (<0.05) with a probability of 82%. It was observed that there is a significant correlation between population genetics and folk music; maternal lineages have a more important role in folk music traditions than paternal lineages. Furthermore, the combination of these disciplines establishing a new interdisciplinary research field of "music-genetics" can be an efficient tool to get a more comprehensive picture on the complex behaviour of populations in prehistoric time.

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Paternal origin of Tungusic‐speaking populations: Insights from the updated phylogenetic tree of Y‐chromosome haplogroup C2a‐M86

Liu

Wang

et al. 2020

American J Hum Biol

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Objectives Haplogroup C2a‐M48 is the predominant paternal lineage of Tungusic‐speaking populations, one of the largest population groups in Siberia. Up until now, the origins and dispersal of Tungusic‐speaking populations have remained unclear. In this study, the demographic history of Tungusic‐speaking populations was explored using the phylogenetic analysis of haplogroup C2a‐M86, the major subbranch of C2a‐M48. Materials and methods In total, 18 newly generated Y chromosome sequences from C2a‐M48 males and 20 previously available Y‐chromosome sequences from this haplogroup were analyzed. A highly revised phylogenetic tree of haplogroup C2a‐M86 with age estimates was reconstructed. Frequencies of this lineage in the literature were collected and a comprehensive analysis of this lineage in 13 022 individuals from 245 populations in Eurasia was performed. Results The distribution map of C2a‐M48 indicated the most probable area of origin and diffusion route of this paternal lineage in North Eurasia. Most C2a‐M86 samples from Tungusic‐speaking populations belonged to the sublineage C2a‐F5484, which emerged about 3300 years ago. We identified six unique sublineages corresponding to the Manchu, Evenks, Evens, Oroqen, and Daurpopulations; these sublineages diverged gradually over the past 1900 years. Notably, we observed a clear north‐south dichotomous structure for sublineages derived from C2a‐F5484, consistent with the internal north‐south divergence of Tungusic languages and ethnic groups. Conclusions We identified the important founding paternal haplogroup, C2a‐F5484, for Tungusic‐speaking populations as well as numerous unique subgroups of this haplogroup. We propose that the timeframe for the divergence of C2a‐F5484 corresponds with the early differentiation of ancestral Tungusic‐speaking populations.

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Northwest Siberian Khanty and Mansi in the junction of West and East Eurasian gene pools as revealed by uniparental markers

Abstract: Northwest Siberia is geographically remote territory, which has been settled by indigenous human populations probably since the Upper Paleolithic.

Cited by 54 publications

References 51 publications

Genetic markers and population history: Finland revisited

Genetic markers and population history: Finland revisited

A comparative phylogenetic study of genetics and folk music

Paternal origin of Tungusic‐speaking populations: Insights from the updated phylogenetic tree of Y‐chromosome haplogroup C2a‐M86

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