North American Prodrome Longitudinal Study (NAPLS 2)

Addington, Jean; Liu, Lu; Buchy, Lisa; Cadenhead, Kristin S.; Cannon, Tyrone D.; Cornblatt, Barbara A.; Perkins, Diana O.; Seidman, Larry J.; Tsuang, Ming T.; Walker, Elaine F.; Woods, Scott W.; Bearden, Carrie E.; Mathalon, Daniel H.; McGlashan, Thomas H.

doi:10.1097/nmd.0000000000000290

Cited by 200 publications

(199 citation statements)

References 22 publications

Supporting

Mentioning

180

Contrasting

Unclassified

Order By: Relevance

“…Suspiciousness and unusual thought content are 2 of the most common attenuated psychotic symptoms, 32 suspiciousness was a predictor in RAP and unusual thought content was a predictor in PREDICT. Other prediction models such as the North American Prodromal Study (NAPLS1) reported that both unusual thought content and suspiciousness were significant predictors in their model, 4 and later in NAPLS 2 33 both unusual thought and suspiciousness were highly relevant in prediction.…”

Section: Discussionmentioning

confidence: 99%

The Role of Cognition and Social Functioning as Predictors in the Transition to Psychosis for Youth With Attenuated Psychotic Symptoms

Addington

Liu

Perkins

et al. 2016

Schizophrenia Bulletin

Self Cite

View full text Add to dashboard Cite

In the literature, there have been several attempts to develop prediction models for youth who are at clinical high risk (CHR) of developing psychosis. Although there are no specific clinical or demographic variables that seem to consistently predict the later transition to psychosis in those CHR youth, in addition to attenuated psychotic symptoms, the most commonly occuring predictors tend to be poor social functioning and certain cognitive tasks. Unfortunately, there has been little attempt to replicate alogorithms. A recently published article by Cornblatt et al suggested that, for individuals with attentuated psychotic symptoms (APS), disorganized communication, suspiciousness, verbal memory, and a decline in social functioning were the best predictors of later transition to psychosis (the RAP model). The purpose of this article was to first test the prediction model of Cornblatt et al with a new sample of individuals with APS from the PREDICT study. The RAP model was not the best fit for the PREDICT data. However, using other variables from PREDICT, it was demonstrated that unusual thought content, disorganized communication, baseline social functioning, verbal fluency, and memory, processing speed and age were predictors of later transition to psychosis in the PREDICT sample. Although the predictors were different in these 2 models, both supported that disorganized communication, poor social functioning, and verbal memory, were good candidates as predictors for later conversion to psychosis.

show abstract

Section: Discussionmentioning

confidence: 99%

The Role of Cognition and Social Functioning as Predictors in the Transition to Psychosis for Youth With Attenuated Psychotic Symptoms

Addington

Liu

Perkins

et al. 2016

Schizophrenia Bulletin

Self Cite

View full text Add to dashboard Cite

show abstract

“…HCs were excluded if they had a first-degree relative with a current or past psychotic disorder. We have previously reported a more detailed description of recruitment procedures, ascertainment, and inclusion and exclusion criteria (Addington et al, 2015). …”

Section: Methodsmentioning

confidence: 99%

Comorbid diagnoses for youth at clinical high risk of psychosis

Addington

Piškulić

Liu

et al. 2017

Schizophrenia Research

Self Cite

104

View full text Add to dashboard Cite

Several studies have demonstrated that youth at clinical high risk (CHR) of developing psychosis have a high prevalence of comorbid psychiatric disorders. Less is known about the impact of comorbid diagnoses on later conversion to psychosis and the change over time. The aim of this study was to determine the frequency and distribution of psychiatric diagnoses at baseline and over time in the North American Prodrome Longitudinal Study (NAPLS 2) and the role of comorbid diagnoses in conversion to psychosis. The NAPLS 2 sample consisted of 744 CHR youth and 276 healthy controls. Only 21% of the CHR group did not have a comorbid diagnosis with many have 2–3 DSM-IV comorbid diagnoses. The most common diagnoses were anxiety and depressive disorders, which did improve over time. The only diagnosis at baseline that differentiated the converters from the non-converters was cannabis misuse. Comorbidity, except for cannabis use, was essentially independent of clinical outcome. It is possible that those with comorbid diagnoses are preferentially the help-seeking individuals that present for help in our clinics and research projects and that those who at risk but do not have a comorbid diagnosis may not be seeking help in the prodromal phase.

show abstract

“…Perceptual abnormalities in CHR differ from full-blown hallucinations by their limited frequency, duration, severity, and the relative intact ability of the individual to question the reality of hallucinatory experience (McGlashan et al, 2010). As in psychotic disorders, perceptual abnormalities are one of the most frequently endorsed attenuated psychotic symptoms in CHR populations (Addington et al, 2015). …”

Section: Introductionmentioning

confidence: 99%

Perceptual abnormalities in clinical high risk youth and the role of trauma, cannabis use and anxiety

Lu¹,

Marshall²,

Cadenhead³

et al. 2017

Psychiatry Research

Self Cite

View full text Add to dashboard Cite

Recent research suggests that perceptual abnormalities are a group of diverse experiences, which have been associated with trauma, cannabis use, and anxiety. Of the attenuated psychotic symptoms that are present in youth at clinical high risk (CHR) of psychosis, perceptual abnormalities tend to be one of the most frequently endorsed symptoms. However, very few studies have explored perceptual abnormalities and their relationships with the above environmental and affective factors in a CHR sample. Four hundred and forty one CHR individuals who met criteria for attenuated psychotic symptom syndrome (APSS) determined by the Structured Interview for Psychosis-risk Syndromes (SIPS) were assessed on the content of their perceptual abnormalities, early traumatic experience, cannabis use and self-reported anxiety. Logistic regression analyses suggested that both simple auditory and simple visual perceptual abnormalities were more likely to be reported by CHR who had early traumatic experiences, who are current cannabis users, and who have higher levels of anxiety. Multiple regression analysis revealed that only trauma and anxiety were independent predictors of both simple auditory and simple visual perceptual abnormalities. It is possible that examining subtypes of perceptual abnormalities in CHR leads to an improved understanding of the prevalence of such symptoms.

show abstract

North American Prodrome Longitudinal Study (NAPLS 2)

Cited by 200 publications

References 22 publications

The Role of Cognition and Social Functioning as Predictors in the Transition to Psychosis for Youth With Attenuated Psychotic Symptoms

The Role of Cognition and Social Functioning as Predictors in the Transition to Psychosis for Youth With Attenuated Psychotic Symptoms

Comorbid diagnoses for youth at clinical high risk of psychosis

Perceptual abnormalities in clinical high risk youth and the role of trauma, cannabis use and anxiety

Contact Info

Product

Resources

About