North American Contact Dermatitis Group Patch Test Results

Warshaw, Erin M.; Belsito, D.; Taylor, James S.; Sasseville, Denis; DeKoven, Joel G.; Zirwas, Matthew J.; Fransway, Anthony F.; Mathias, C. G. Toby; Zug, Kathryn A.; DeLeo, Vincent A.; Fowler, Joseph F.; Marks, James G.; Pratt, Melanie D.; Storrs, Frances J.; Maibach, Howard I.

doi:10.1097/der.0b013e3182819c51

Cited by 202 publications

(89 citation statements)

References 19 publications

(11 reference statements)

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“…A importância de seu monitoramento constitui um fato digno de a cada dois anos o grupo norte-americano de DC coletar e apresentar dados dos resultados do patch test de uma série padronizada de alérgenos [11][12][13].…”

Section: Discussionunclassified

Principais sensibilizantes em pacientes idosos e não idosos com dermatite de contato

Calamita

2016

Sci Med

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Este artigo está licenciado sob forma de uma licença Creative Commons Atribuição 4.0 Internacional, que permite uso irrestrito, distribuição e reprodução em qualquer meio, desde que a publicação original seja corretamente citada. Resultados: Foram incluídos 362 pacientes, entre o quais 60 idosos (idade maior ou igual a 60 anos) e 302 não idosos. Além da dermatite de contato foram observados outros tipos de alergias em 20 (33,3%) dos idosos e em 113 (37,4%) dos não idosos (p=0,54). Houve um total de 162 reações positivas ao patch test entre os idosos e 738 reações positivas entre os não idosos (p=0,24). Quanto às reações positivas fortes ocorreram 41 (68,3%) entre os idosos e 156 (51,6%) entre os não idosos (p=0,02). Somando-se reações positivas fortes e muito fortes, foram 44 (73,3%) em idosos e 214 (70,8%) em não idosos (p=0,69). As substâncias mais sensibilizantes foram o sulfato de níquel (em 33,3% dos idosos e 38 % dos não idosos) e o perfume mix (em 25% dos idosos e 27,8% dos não idosos), sem diferença estatística entre os dois grupos etários. Conclusões: A taxa de positividade do patch test entre os pacientes com dermatite de contato foi alta, não havendo diferença entre idosos e não idosos, sendo o sulfato de níquel e o perfume mix as substâncias mais sensibilizantes. Na investigação etiológica da dermatite de contato deve-se pensar principalmente na possibilidade de sensibilização aos perfumes e ao níquel, independentemente da faixa etária. DESCRITORES: dermatite de contato; idoso; perfumes; níquel; testes do emplastro. ABSTRACT Aims:To evaluate the prevalence of the main allergens found in allergic contact dermatitis among elderly and non-elderly patients. Methods: Retrospective study of the medical records of patients clinically diagnosed with contact dermatitis treated from August 2000 to January 2012 at the Allergy Outpatient Clinic of Marília Medical School and at an Allergy and Dermatology private clinic in Marília, state of São Paulo, Brazil. The inclusion criteria were clinical diagnosis of contact dermatitis, patch test performed during the study period, and no treatment with systemic corticosteroids or any other immunosuppressants. Age, sex, history of other types of allergy and allergens used were assessed. The patch test results were read 48 hours and 72 hours after application of the test chambers. Results: A total of 362 patients were included in the study: 60 elderly patients (aged 60 years or older) and 302 non-elderly patients. In addition to contact dermatitis, other types of allergies were observed in 20 (33.3%) of elderly patients and in 113 (37.4%) of non-elderly patients (p=0.54). There were 162 positive reactions on the patch test among elderly patients and 738 positive reactions among non-elderly patients (p=0.24). Strong positive reactions were present in 41 (68.3%) elderly patients and in 156 (51.6%) non-elderly patients (p=0.02). Strong and very strong positive reactions, when assessed together, were detected in 44 (73.3%) elderly patients and in 214 (70.8%) non-elderly patient...

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Section: Discussionunclassified

Principais sensibilizantes em pacientes idosos e não idosos com dermatite de contato

Calamita

2016

Sci Med

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“…The North American contact dermatitis group regularly published collated diagnostic patch test data (Table 2). 51,52 The number of contact allergens tested in the earlier period was much lower, but for the 15 where a direct comparison can be made, it is evident that the passage of more than a quarter of a century has not been associated with a general reduction in the rates of response to these common sensitizers. A sample of data from Europe is displayed in Table 3, which contains results from a French baseline series applied in 1991 and 2011.…”

Section: Skin Sensitization Hazard Identification and Characterizationmentioning

confidence: 99%

Skin sensitization

et al. 2015

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Skin sensitization associated with allergic contact dermatitis is a common health problem and is an important consideration for toxicologists in safety assessment. Historically, in vivo predictive tests have been used with good success to identify substances that have the potential to induce skin sensitization, and these tests formed the basis of safety evaluation. These original tests are now being replaced gradually either by in vitro assays or by further refinements of in vivo methods such as the local lymph node assay. Human data have also been available to inform classification decisions for some substances and have been used by risk managers to introduce measures for exposure reduction. However, humans encounter hazards in the context of exposure rather than in the form of intrinsic hazards per se, and so in this article, we have examined critically the extent to which human data have been used to refine classification decisions and safety evaluations. We have also evaluated information on the burden of human allergic skin disease and used this to address the question of whether, and to what extent, the identification and evaluation of skin sensitization hazards has led to an improvement of public and/or occupational health.

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“…Test series are under constant revision to achieve adaptation to changing allergen exposure patterns in the patients. Patch test results from single departments, national networks [ 12 ], or from international networks [ 13 ] are published to serve the purpose of CA surveillance, identifying targets of further in-depth research and preventive action, respectively.…”

mentioning

confidence: 99%