Norsquaraine endowed with anticancer and antibacterial activities

Toksoy, Alihan; Sonkaya, Ömer; Erkan, Dilek Sadife; Gulen, Rukiye Boran; Algı, Melek Pamuk; Algı, Fatih

doi:10.1016/j.pdpdt.2022.103110

Cited by 5 publications

(5 citation statements)

References 45 publications

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“…An increased reactivity of oxygen species was observed. In addition, the use of PDT in combination with Norsquaraine 1 yielded a high efficacy of 77-89% cachexia of the tumor cells [124].…”

Section: Pdt Therapy In the Laryngeal Areamentioning

confidence: 99%

Photodynamic Therapy for Eye, Ear, Laryngeal Area, and Nasal and Oral Cavity Diseases: A Review

Domka,

Bartusik-Aebisher,

Mytych

et al. 2024

Cancers

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Photodynamic therapy (PDT) has emerged as a promising modality for the treatment of various diseases. This non-invasive approach utilizes photosensitizing agents and light to selectively target and destroy abnormal cells, providing a valuable alternative to traditional treatments. Research studies have explored the application of PDT in different areas of the head. Research is focusing on a growing number of new developments and treatments for cancer. One of these methods is PDT. Photodynamic therapy is now a revolutionary, progressive method of cancer therapy. A very important feature of PDT is that cells cannot become immune to singlet oxygen. With this therapy, patients can avoid lengthy and costly surgeries. PDT therapy is referred to as a safe and highly selective therapy. These studies collectively highlight the potential of PDT as a valuable therapeutic option in treating the head area. As research in this field progresses, PDT may become increasingly integrated into the clinical management of these conditions, offering a balance between effectiveness and minimal invasiveness.

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“…An increased reactivity of oxygen species was observed. In addition, the use of PDT in combination with Norsquaraine 1 yielded a high efficacy of 77-89% cachexia of the tumor cells [124].…”

Section: Pdt Therapy In the Laryngeal Areamentioning

confidence: 99%

Photodynamic Therapy for Eye, Ear, Laryngeal Area, and Nasal and Oral Cavity Diseases: A Review

Domka,

Bartusik-Aebisher,

Mytych

et al. 2024

Cancers

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“…demonstrates how the probe operates in light settings and demonstrates dose-based effectiveness [62]. Eurico Lima et al have synthesized six squaraine dyes that effectively generate ROS faster than the commercially available FDA-approved standard methylene blue [61].…”

Section: Applications Of Indole-based Dyesmentioning

confidence: 99%

“…This is achieved because the probe is an effective photosensitizer for photodynamic therapy. The probe can generate reactive oxygen species (ROS), a known tool for killing cancer cells [ 61 , 62 ]. An important point is to minimize cytotoxicity when added to healthy cells.…”

Section: Indole-based Squaraine Dyesmentioning

confidence: 99%

“…The dye utilizes photodynamic therapy to generate ROS species to eliminate Methicillin-resistant Staphylococcus aureus (MRSA), a drug-resistant bacteria. Figure 8 B demonstrates how the probe operates in light settings and demonstrates dose-based effectiveness [ 62 ].…”

Section: Indole-based Squaraine Dyesmentioning

confidence: 99%

“…( B ). The bacterial viability of Methicillin-resistant Staphylococcus aureus (MRSA) in dark and light conditions at varying concentrations [ 62 ].…”

Section: Figures Schemes and Tablesmentioning

confidence: 99%

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Exploration of NIR Squaraine Contrast Agents Containing Various Heterocycles: Synthesis, Optical Properties and Applications

Sarasiya,

Henary

2023

Pharmaceuticals

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Squaraine dye is a popular class of contrast near-infrared (NIR) dyes. Squaraine dyes have shown the ability to be modified with various heterocycles. The indole moiety is the most notable heterocycle incorporated in squaraine dyes. A tremendous amount of work has gone into developing indole-based squaraine dyes and determining their applications. The optical properties of squaraine dyes containing an indole moiety facilitate high quantum yields and molar absorptivity, but the absorbance maxima is capped near 700 nm. This is the major limitation of indole-based squaraine dyes. In comparison, other heterocycles with larger conjugated systems such as quinoline and perimidine have demonstrated promising optical properties and immense potential for modifications, albeit with limited development. Quinoline- and perimidine-based squaraine dyes have molar extinction coefficients over 100,000 M−1 cm−1 and absorbances over 800 nm. This report will look at indole-, quinoline-, and perimidine-based squaraine dyes. Due to the sheer number of reported dyes, the search for indole-based squaraine dyes has been limited to reports from the past five years (2018–2023). For quinoline- and perimidine-based squaraine dyes, a holistic search was performed to analyze the optical properties and applications, due to the abovementioned limitation. This report will evaluate the three different classes of squaraines: indole-, quinoline-, and perimidine-based, to evaluate their optical properties and applications, with the goal of encouraging the exploration of other heterocycles for use in squaraine dyes.

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A generic platform for self-illuminating unimolecular systems enabling photodynamic therapy

et al. 2023

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Norsquaraine endowed with anticancer and antibacterial activities

Cited by 5 publications

References 45 publications

Photodynamic Therapy for Eye, Ear, Laryngeal Area, and Nasal and Oral Cavity Diseases: A Review

Photodynamic Therapy for Eye, Ear, Laryngeal Area, and Nasal and Oral Cavity Diseases: A Review

Exploration of NIR Squaraine Contrast Agents Containing Various Heterocycles: Synthesis, Optical Properties and Applications

A generic platform for self-illuminating unimolecular systems enabling photodynamic therapy

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