Norsesquiterpenoids from the leaves of Croton tiglium

Abstract

These authors contributed equally to this work. (2), together with 13 known norsesquiterpenes, were isolated from the leaves of Croton tiglium L. The structures of the new compounds were established by means of spectroscopic methods. The absolute configuration of badounoid B was determined by single-crystal X-ray diffraction analysis. All the known compounds were isolated from Croton plants for the first time which added a new chemical facet for this genus. The selected compounds were evaluated for their cytostatic activity against several cancer cell lines. None of them was found to be active.

Study on the quality evaluation of the leaves of Croton tiglium from different regions based on quality markers

“…LCT mainly contains diterpenoids, alkaloids, sesquiterpenoids, phenylpropanoids, volatile oils, and other components, 9–12 and its extracts have antioxidant, antitumour, and skin‐parasitic effects 12 . Diterpenoids, including clerodane, tigliane, kaurane, labdane, cembrane, and pimarane, are characteristic components of Croton species 13 and the main secondary metabolites of C. tiglium .…”

“…[5][6][7][8] LCT mainly contains diterpenoids, alkaloids, sesquiterpenoids, phenylpropanoids, volatile oils, and other components, [9][10][11][12] and its extracts have antioxidant, antitumour, and skin-parasitic effects. 12 Diterpenoids, including clerodane, tigliane, kaurane, labdane, cembrane, and pimarane, are characteristic components of Croton species 13 and the main secondary metabolites of C. tiglium. The diterpenoids in LCT have significant pharmacological activities, including antitumour, antituberculosis, and anti-inflammatory, [9][10][11]14 of which tigliane diterpenoids are considered significant components owing to their high percentage 15 and significant activity.…”

“…Several scholars have used Q-markers as the core to study the quality of Chinese medicinal materials and have gradually explored new research models of the quality of TCM. [5][6][7][8] LCT mainly contains diterpenoids, alkaloids, sesquiterpenoids, phenylpropanoids, volatile oils, and other components, [9][10][11][12] and its extracts have antioxidant, antitumour, and skin-parasitic effects. 12 Diterpenoids, including clerodane, tigliane, kaurane, labdane, cembrane, and pimarane, are characteristic components of Croton species 13 and the main secondary metabolites of C. tiglium.…”