Norovirus strains among children aged 0–18 years hospitalized with acute gastroenteritis in Estonia 2015–2016

Kõivumägi, Kadri; Geller, Julia; Toompere, Karolin; Soeorg, Hiie; Kallas, Eveli; Jõegeda, Ene-Ly; Huik, Kristi; Lutsar, Irja

doi:10.1002/jmv.27495

Cited by 4 publications

(1 citation statement)

References 30 publications

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“…In contrast, only GII.4 Sydney(P4) has been previously reported at a high frequency in Nigeria [ 23 ], suggesting a common phenomenon in the country. Elsewhere in Europe [ 47 ], GII.4 Sydney(P4) and GII.4 New Orleans(P4) were reported. The observed increase in the proportion of recombinant strains from 2016 to 2017 suggests a circulation pattern, although limited recombinants were detected.…”

Section: Discussionmentioning

confidence: 99%

Genetic Diversity of Norovirus in Children with Acute Gastroenteritis in Southwest Nigeria, 2015–2017

Arowolo

Ayolabi

Adeleye

et al. 2023

Viruses

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Norovirus (NoV) is a leading cause of viral gastroenteritis globally, especially in children below five years. Epidemiological studies on the diversity of NoV in middle- and low-income countries, including Nigeria, are limited. This study aimed to determine the genetic diversity of NoV in children below five years with acute gastroenteritis at three hospitals in Ogun State, Nigeria. A total of 331 fecal samples were collected from February 2015 to April 2017, while 175 were randomly selected and analyzed using RT-PCR, partial sequencing and phylogenetic analyses of both the polymerase (RdRp) and capsid (VP1) genes. NoV was detected in 5.1% (9/175; RdRp) and 2.3% (4/175; VP1) of samples, with 55.6% (5/9) co-infection with other enteric viruses. A diverse genotype distribution was identified, and GII.P4 was the dominant RdRp genotype detected (66.7%), with two genetic clusters, followed by GII.P31 (22.2%). The rare GII.P30 genotype (11.1%) was detected at a low rate for the first time in Nigeria. Based on the VP1 gene, GII.4 was the dominant genotype (75%), with two variants, Sydney 2012 and possibly New Orleans 2009, co-circulating during the study. Interestingly, both intergenotypic, GII.12(P4) and GII.4 New Orleans(P31), and intra-genotypic, GII.4 Sydney(P4) and GII.4 New Orleans(P4), putative recombinant strains were observed. This finding suggests the first likely report of GII.4 New Orleans(P31) in Nigeria. In addition, GII.12(P4) was first described in Africa and globally in this study, to the best of our knowledge. This study provided insights into the genetic diversity of NoV circulating in Nigeria, which would be useful for ongoing and future vaccine design and monitoring of emerging genotypes and recombinant strains.

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Section: Discussionmentioning

confidence: 99%

Genetic Diversity of Norovirus in Children with Acute Gastroenteritis in Southwest Nigeria, 2015–2017

Arowolo

Ayolabi

Adeleye

et al. 2023

Viruses

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High prevalence of norovirus GII.4 Sydney among children with acute gastroenteritis in Bangladesh, 2018–2021

Sharif,

Ahmed,

Sharif

et al. 2023

Journal of Infection and Public Health

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Human adenoviruses in children with gastroenteritis: a systematic review and meta-analysis

Khales,

Razizadeh,

Ghorbani

et al. 2024

BMC Infect Dis

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Purpose Human adenoviruses (HAdVs) have always been suggested as one of the main causes of gastroenteritis in children. However, no comprehensive report on the global epidemiology of these viruses in pediatric gastroenteritis is available. Methods A systematic search was conducted to obtain published papers from 2003 to 2023 in three main databases PubMed, Scopus, and Web of Science. Results The estimated global pooled prevalence of HAdV infection in children with gastroenteritis was 10% (95% CI: 9-11%), with a growing trend after 2010. The highest prevalence was observed in Africa (20%, 95% CI: 14–26%). The prevalence was higher in inpatients (11%; 95% CI: 8-13%) and patients aged 5 years old and younger (9%; 95% CI: 7-10%). However, no significant difference was observed between male and female patients (P = 0.63). The most prevalent species was found to be the species F (57%; 95% CI: 41-72%). The most common HAdVs observed in children with gastroenteritis were types 40/41, 38, and 2. Analysis of case-control studies showed an association between HAdV and gastroenteritis in children (OR: 2.28, 95% CI; 1.51–3.44). Conclusion This study provided valuable insights into the importance of HAdVs in children with gastroenteritis, especially in hospitalized and younger children. The results can be used in future preventive measurements and the development of effective vaccines.

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Norovirus strains among children aged 0–18 years hospitalized with acute gastroenteritis in Estonia 2015–2016

Cited by 4 publications

References 30 publications

Genetic Diversity of Norovirus in Children with Acute Gastroenteritis in Southwest Nigeria, 2015–2017

Genetic Diversity of Norovirus in Children with Acute Gastroenteritis in Southwest Nigeria, 2015–2017

High prevalence of norovirus GII.4 Sydney among children with acute gastroenteritis in Bangladesh, 2018–2021

Human adenoviruses in children with gastroenteritis: a systematic review and meta-analysis

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