Norovirus Infection in Belarus: Occurrence and Molecular Epidemiology

Abstract

SUMMARYThe objective of the study is to analyze molecular epidemiologic surveillance for norovirus infection in Belarus over the past five years (2009)(2010)(2011)(2012)(2013). Laboratory diagnostics was carried out by RT-PCR in 684 patients. Two regions of norovirus genome, localized in RNA-polymerase and capsid protein genes, were used for phylogenetic analysis.Noroviruses were predominant causative agents in adults and second only to rotaviruses in children, they also prevailed among aetiological agents of outbreaks (66.7% of outbreaks). In 2009-2013, the major norovirus genotype was GII.4 (58.3% of all genotyped isolates). Genovariant GII.4 2006b circulated in 2009 and 2010, genovariant GII.4 2009 New Orleans -in 2010and 2012. In addition to GII.4, genotypes GII.6 (16.6%), GII.2 (4.1%), GII.3 (2.2%), and recombinant genotypes GII.g-GII.12 and GII.g-GII.1 (10.4% and 8.3%, respectively) circulated in Belarus.The findings indicate a significant contribution of noroviruses in development of sporadic morbidity and outbreaks of acute gastroenteritis in Belarus. Outbreaks or prominent increases of sporadic morbidity were mostly due to the emergence of a new genotype, or an epidemic genovariant.

The Comparative Molecular Epidemiology of GII.P7_GII.6 and GII.P7_GII.7 Norovirus Outbreaks in Victoria, Australia, 2012-2014

“…Although GII.6 (ORF 2) and GII.7 (ORF 2) noroviruses have been documented in various studies [6,7,8] and GII.6 (ORF 2) has been noted to be a relatively common norovirus in some settings [9,10,11,12], detailed molecular epidemiological analysis of these viruses is lacking. Furthermore, although a link between GII.6 and GII.7 noroviruses has been documented, in that both can be linked to GII.P7 [13,14,15,16], the precise relationship between GII.P7_GII.6 and GII.P7_GII.7 does not appear to have been examined.…”