Norovirus in benign convulsions with mild gastroenteritis

Kim, Gun Ha; Byeon, Jung Hye; Lee, Deog‐Yong; Jeong, Hyun Ju; Eun, Baik Lin

doi:10.1186/s13052-016-0303-2

Cited by 17 publications

(53 citation statements)

References 19 publications

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“…In the present study, norovirus was noted in 45.7% of cases, while rotavirus was noted only in 4.3% of cases. The proportion of rotavirus observed in our study was lower than those reported in previous studies 16,19) . Regarding seasonal distributions, CwG were prevalent in the winter months, between November and March, in this study area (Fig.…”

Section: Seizure Characteristics In Children With Practical Status Epcontrasting

confidence: 92%

“…Regarding seasonal distributions, CwG were prevalent in the winter months, between November and March, in this study area (Fig. 1), which is consistent with the incidence of norovirus infection in previous reports from other countries [19][20][21]24,29) .…”

Section: Seizure Characteristics In Children With Practical Status Epsupporting

confidence: 91%

“…Currently, norovirus is the most common pathogen of viral gastroenteritis in South Korea 14,15) . Kim et al 19) reported the common pathogens of viral gastroenteritis to include norovirus (63.0% of cases) and rotavirus (8.7%), followed by enteric adenovirus (8.7%), and astrovirus (2.8% of cases). This tendency seems to be a global phenomenon since the introduction of rotavirus vaccination 16,18,22,24) .…”

Section: Seizure Characteristics In Children With Practical Status Epmentioning

confidence: 99%

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Convulsions with Noroviral Gastroenteritis in Children at a Single Center in Korea

강수연¹,

이현주²,

김신혜³

2018

Child Neurol

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Viral gastroenteritis is a common disease in infants and children. Seizures can be associated with viral gastroenteritis as benign convulsions with mild gastroenteritis (CwG). After the development of the rotavirus vaccination, norovirus has become inreasingly significant in children. We retrospectively analyzed the clinical features in a pediatric population presenting with seizures and confirmed enteral viral infections, especially norovirus infections. Methods: We retrospectively reviewed the medical records of pediatric patients aged <15 years admitted due to convulsions and gastroenteritis to the Department of Pediatrics of Myongji Hospital between July 2014 and June 2016. Results: A total of 46 patients (24 male and 22 female) were included. Norovirus was detected in 21 (45.7%) patients, adenovirus in three (6.5%), rotavirus in two (4.3%), astrovirus in one (2.2%), and none of agents were detected in 19 (41.3%) patients. Patients in the norovirus gastroenteritis (NGE) group had a higher incidence of diarrhea than that among in the non-norovirus gastroenteritis (NNGE) group (61.9% vs 28.0%; P<0.05). Twelve patients experienced status epilepticus, including five (23.8%) in the NGE group and seven (33.0%) in the NNGE group (P=0.837). Seizures were effectively terminated by intravenous benzodiazepines in 8 (66.7%) of 12 patients. Additional long-acting antiepileptic drugs such as fosphenytoin or levetiracetam were required in three (25%) of 12 patients. Conclusion: Patients with CwG with and without noroviurs infection did not differ in terms of clinical features. However, status epilepticus was not uncommon among patients with CwG by definition.

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Section: Seizure Characteristics In Children With Practical Status Epcontrasting

confidence: 92%

Section: Seizure Characteristics In Children With Practical Status Epsupporting

confidence: 91%

Section: Seizure Characteristics In Children With Practical Status Epmentioning

confidence: 99%

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Convulsions with Noroviral Gastroenteritis in Children at a Single Center in Korea

강수연¹,

이현주²,

김신혜³

2018

Child Neurol

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“…Specific viral infections, such as adenovirus, herpes simplex virus, human herpesvirus-6, influenza, and respiratory syncytial virus, were associated with febrile seizures (Lin et al, 2014). Rotavirus and norovirus enteritis are associated with benign convulsions in childhood (Kim et al, 2016;Yorulmaz, Sert & Yilmaz, 2017). Furthermore, brain inflammation can be induced by the cyclooxygenase-2-PeerJ reviewing PDF | (2017:12:22691:1:1:NEW 20 Apr 2018)…”

Section: Discussionmentioning

confidence: 99%

Peer Review #1 of "Association of epilepsy and asthma: a population-based retrospective cohort study (v0.1)"

2018

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Background. Epidemiologic data supporting the epilepsy-asthma association are insufficient. Therefore, we examined this association in this study. Methods. By using claims data from the National Health Insurance Research Database (Taiwan), we executed a retrospective cohort analysis. Analysis 1 entailed comparing 150,827 patients diagnosed as having incident asthma during 1996-2013 with disease-free controls who were selected randomly during the same period, frequency matched in terms of age and sex. Similarly, analysis 2 entailed comparing 25,274 patients newly diagnosed as having epilepsy with sex-and age-matched controls who were selected randomly. At the end of 2013, we evaluated in analysis 1 the epilepsy incidence and risk and evaluated in analysis 2 the asthma incidence and risk. We applied Kaplan-Meier analysis to derive plots of the proportion of asthma-free seizures. Results. In analysis 1, the asthma group exhibited a higher epilepsy incidence than did the control group (3.05 versus 2.26 per 1,000 person-years; adjusted hazard ratio: 1.39, 95% confidence interval: 1.33-1.45). We also noted a greater risk of subsequent epilepsy in women and girls. In analysis 2, we determined that the asthma incidence between the control and epilepsy groups did not differ significantly; however, some age subgroups including children and individuals in their 30s had an increased risk. A negative association was found in adolescents. The Kaplan-Meier analysis revealed epilepsy to be positively associated with subsequent onset of asthma within 7 years of epilepsy diagnosis. Discussion. Asthma may be associated with high epilepsy risk, and epilepsy may be associated with high asthma risk among children and individuals in their 30s. Nevertheless, people with epilepsy in other age subgroups should be aware of the possibility of developing asthma within 7 years of epilepsy diagnosis.

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“…However, when the patient has symptoms of diarrhea and/or vomiting before or after seizures, this can indicate the presence of benign convulsions with mild gastroenteritis (CwG) . Additionally, if the season is early winter or spring when rotavirus and norovirus are prevalent, CwG have to be considered in patients especially between 13 to 24 months of age with short-lasting seizures (less than 5 minutes) occurring in clusters [3][4][5][6][7][8][9][10][11][12]15,16,19,24].…”

Section: Introductionmentioning

confidence: 99%

Benign Convulsions with Mild Gastroenteritis

Kim

2020

Ann Child Neurol

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Benign convulsions with mild gastroenteritis (CwG) are a well-known type of benign seizures that occur in infants and children aged between 6 months and 3 years and are associated with acute (viral) gastroenteritis. The pathogens found in the stool of CwG patients are mostly rotavirus or norovirus, which can result in mild dehydration. Short-lasting seizures (≤5 minutes) occur in clusters within 24 hours, without provoking features such as fever, abnormal laboratory findings in the blood (e.g., hypoglycemia, hyponatremia, or hypocalcemia), or abnormal results in the cerebrospinal fluid (e.g., central nervous system infection). Electroencephalography in CwG patients shows normal or mildly abnormal findings, and brain imaging findings are normal. Affected children develop normally before and after the seizures. The occurrence of seizures does not require the repeated use of first-or second-line intravenous antiepileptic drugs in the acute stage or daily antiepileptic drug medications, since they usually do not recur and have a good prognosis. Patients with CwG rarely have a family history of epilepsy. Although the mean interval between enteric symptom onset and seizure onset in CwG is roughly 2 days, some patients can experience seizures before enteric symptoms, meaning that clinicians should exercise caution during early winter and spring, when the prevalence of CwG is especially high. Additionally, reports of CwG in Korea are roughly as common as in Japan and other East Asian countries, and pediatricians should therefore be familiar with its clinical characteristics and take care not to overprescribe antiepileptic drugs in patients with CwG.

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Norovirus in benign convulsions with mild gastroenteritis

Cited by 17 publications

References 19 publications

Convulsions with Noroviral Gastroenteritis in Children at a Single Center in Korea

Convulsions with Noroviral Gastroenteritis in Children at a Single Center in Korea

Peer Review #1 of "Association of epilepsy and asthma: a population-based retrospective cohort study (v0.1)"

Benign Convulsions with Mild Gastroenteritis

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